(R)-N-(3-Aminopropyl)-N-(1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropyl)-4-Methylbenzamide (R)-N-(3-氨基丙基)-N-(1-(3-苄基-7-氯-4-氧代-3,4-二氢喹唑啉-2-基)-2-甲基丙基)-4-甲基苯甲酰胺
CAS 336113-53-2 MFCD36113532
化学结构图
SMILES: Cc1ccc(C(=O)N(CCCN)[C@@H](c2nc3cc(Cl)ccc3c(=O)n2Cc2ccccc2)C(C)C)cc1
化学属性
| Mol. Weight | 517.06 |
|---|---|
| Mol. Formula | C30H33ClN4O2 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 336113-53-2 |
|---|---|
| Chemical Name | (R)-N-(3-Aminopropyl)-N-(1-(3-Benzyl-7-Chloro-4-Oxo-3,4-Dihydroquinazolin-2-Yl)-2-Methylpropyl)-4-Methylbenzamide |
| Synonym | N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide SB 715992 SB715992; SB-715992; SB 715992; CK 0238273; CK-0238273; CK0238273. |
| Chemical Name Translation | (R)-N-(3-氨基丙基)-N-(1-(3-苄基-7-氯-4-氧代-3,4-二氢喹唑啉-2-基)-2-甲基丙基)-4-甲基苯甲酰胺 |
| Formula | C30H33ClN4O2 |
| IUPAC Name | (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide |
| InChIKey | QJZRFPJCWMNVAV-HHHXNRCGSA-N |
| InChI | InChI=1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1 |
| Canonical SMILES | O=C(N(CCCN)[C@@H](C(N1CC2=CC=CC=C2)=NC3=C(C=CC(Cl)=C3)C1=O)C(C)C)C4=CC=C(C)C=C4 |
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分类
- Chiral Reagents
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
相关文献及参考
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