2H-1,3,2-Oxazophosphorine,2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-,2-oxide

CAS 39800-16-3 MFCD39800163

化学结构图

39800-16-3
SMILES: OO[C@H]1CCO[P@](=O)(N1)N(CCCl)CCCl

化学属性

Mol. Weight293.11
Mol. FormulaC7H15Cl2N2O4P

别名和识别编码

CAS Number39800-16-3
Chemical Name2H-1,3,2-Oxazophosphorine,2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-,2-oxide
Synonym Hydroperoxide, ASTA 6496 2-(Bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-[Bis(2-chloroethyl)amino]tetrahydro-2-oxido-2H-1,3,2-oxazaphosphorin-4-yl
Wiswesser Line NotationT6MPOTJ BN2G2G FOQ
Beilstein Registry Number0531579
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Phosphorylating and Phosphitylating Agents,

产品应用

  • A metabolite of Cyclophosphamide. Antineoplastic; bone marrow purging agent.

相关文献及参考

  • Biggs, D., et al.: Prog. Clin. Biol. Res., 389, 9 (1994),
  • Jones, R.J., et al.: J. Hematother., 1, 343 (1992),
  • Takamizawa, A., et al.: J. Med. Chem., 18, 376 (1975),
  • [1]. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG

安全信息

RTECSRP5900000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76040 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   39,1,1982

TYPE OF T

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 6 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   39,191,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 15 mg/L
REFERENCE :
   EXHMA6 Experimental Hematology (New York).  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1973-
   Volume(issue)/page/year: 13,1014,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 500 umol/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 3,637,1977

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - rat Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 300 mg/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5 mg/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   35,1163,1986

{haza

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. Drug Metabolite  (药物代谢物)

相关产品推荐