Simvastatin Acyl-β-D-glucuronide
CAS 463962-56-3 MFCD63962563
化学结构图
SMILES: CCC(C)(C)C(=O)O[C@@H]1C[C@H](C)C=C2C=C[C@@H](C)[C@@H](CC[C@H](O)C[C@H](O)CC(=O)O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)[C@@H]21 |&1:8,10,16,18,21,24,30,32,33,35,37,42|
化学属性
| Mol. Weight | 612.71 |
|---|---|
| Mol. Formula | C31H48O12 |
别名和识别编码
| CAS Number | 463962-56-3 |
|---|---|
| Chemical Name | Simvastatin Acyl-β-D-glucuronide |
| Synonym | 1-[(?R,?R,1S,2S,6R,8S,8aR)-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoate] ?-D-Glucopyranuronic Acid |
| Chemical Name Translation |
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分类
- Chiral Reagents
- Glucuronides
- Metabolites & Impurities
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A metabolite of Simvastatin.
相关文献及参考
- Billecke, S., et al.: Drug Metab. Dispos., 28, 1335 (2000),
- Draganov, D., et al.: J. Biol. Chem., 275, 33435 (2000),
- Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001),
- [1]. Prueksaritanont T, Subramanian R, Fang X, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002;30(5):505‐512.
