1-[4-(2-Methoxyphenyl)Piperazin-1-yl]-3-Naphthalen-1-Yloxypropan-2-ol;Dihydrochloride 盐酸萘哌地尔
CAS 57149-08-3 MFCD57149083
化学结构图
SMILES: COC1C=CC=CC=1N1CCN(CC(O)COC2C=CC=C3C=CC=CC3=2)CC1
化学属性
| Mol. Weight | 392.50 |
|---|---|
| Mol. Formula | C24H28N2O3 |
| Melting Point | 125.0 to 129.0 deg-C |
别名和识别编码
| CAS Number | 57149-08-3 |
|---|---|
| Chemical Name | 1-[4-(2-Methoxyphenyl)Piperazin-1-yl]-3-Naphthalen-1-Yloxypropan-2-ol;Dihydrochloride |
| Synonym | rac-4-(2-Methoxyphenyl)-?-[(1-naphthalenyloxy)methyl]-1-piperazineethanol Dihydrochloride Avishot Flivas KT 611 |
| Chemical Name Translation | 盐酸萘哌地尔 |
| Reaxys-RN | 629965 |
| Beilstein Registry Number | 23(5)2,135 |
| MDL Number | MFCD00242741 |
| PubChem Substance ID | 87560652 |
| Merck Number | 6356 |
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分类
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- A ?-1-Adrenergic receptor antagonist, antihypertensive.
相关文献及参考
- [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.
- Farthing, M.J.G., et al.: Postgrad. Med. J., 70, 363 (1994),
- Kirsten, et al.: Eur. J. Clin. Pharmacol., 46, 271 (1994),
- [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
- [1]. R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.
- [2]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by alterin
