Isosilybin
CAS 72581-71-6 MFCD72581716
化学结构图
SMILES: COC1C=C(C=CC=1O)C1OC2C=CC(=CC=2OC1CO)C1OC2C=C(O)C=C(O)C=2C(=O)C1O
化学属性
| Mol. Weight | 482.44 |
|---|---|
| Mol. Formula | C25H22O10 |
别名和识别编码
| CAS Number | 72581-71-6 |
|---|---|
| Chemical Name | Isosilybin |
| Synonym | (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one Isosilybinin |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Useful in the treatment of liver disease.
相关文献及参考
- [2]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.
- [3]. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.
- [4]. Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77(4):842-7.
- Parthasarathy, M.R., et al.: Phytochemistry, 18, 506 (1979),
- [1]. Mooiman KD, et al. Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. Drug Metab Dispos. 2
- [1]. Mooiman KD, et al. Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. Drug Metab Dispos. 2013 Aug;41(8):1494-504.
