N-(4-Methoxyphenyl)-N,2-Dimethylquinazolin-4-Amine (4-甲氧基苯基)(甲基)(2-甲基喹唑啉-4-基)胺
CAS 827031-83-4 MFCD27031834
化学结构图
SMILES: COc1ccc(N(C)c2nc(C)nc3ccccc23)cc1
化学属性
| Mol. Formula | C17H17N3O |
|---|---|
| Mol. Weight | 279.34 |
| Appearance | White solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-(4-Methoxyphenyl)-N,2-Dimethylquinazolin-4-Amine |
|---|---|
| Chemical Name Translation | (4-甲氧基苯基)(甲基)(2-甲基喹唑啉-4-基)胺 |
| Chemicalbook ID | CB02574640 |
| Formula | C17H17N3O |
| Synonym | MPC6827; MPC-6827; MPC 6827; MX128495; MX-128495; MX 128495; EP90745; EP-90745;EP 90745; Verubulin; trade name: Azixa |
| IUPAC Name | N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine |
| InChIKey | SNHCRNMVYDHVDT-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H17N3O/c1-12-18-16-7-5-4-6-15(16)17(19-12)20(2)13-8-10-14(21-3)11-9-13/h4-11H,1-3H3 |
| Canonical SMILES | CC1=NC(N(C2=CC=C(OC)C=C2)C)=C3C=CC=CC3=N1 |
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产品应用
- Verubulin, also known as MPC-6827, is a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. MPC-6827 appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death.
