Belinostat 贝利司他
CAS 866323-14-0 MFCD66323140
化学结构图
SMILES:
化学属性
| Mol. Formula | C15H14N2O4S |
|---|---|
| Mol. Weight | 318.34 |
| Appearance | White Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | Belinostat |
|---|---|
| Chemical Name Translation | 贝利司他 |
| Chemicalbook ID | CB82628305 |
| Formula | C15H14N2O4S |
| Synonym | PXD 101; PXD101; PXD-101; PX105684; PX-105684; PX 105684; NSC726630; brand name: Beleodaq. |
| IUPAC Name | (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. |
| InChIKey | NCNRHFGMJRPRSK-MDZDMXLPSA-N |
| InChI | InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+ |
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产品应用
- Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. Belinostat was approved in 2014 for relapsed or refractory peripheral T-cell lymphoma.
