Evocalcet
CAS 870964-67-3 MFCD70964673
化学结构图
SMILES: C[C@@H](N[C@H]1CCN(c2ccc(CC(=O)O)cc2)C1)c1cccc2ccccc12
化学属性
| Appearance | Solid powder |
|---|---|
| Solubility | Soluble in DMSO, not in water |
| Mol. Weight | 374.48 |
别名和识别编码
| Chemical Name Translation | |
|---|---|
| Synonym | MT-4580; MT 4580; MT4580; KHK-7580; KHK7580; KHK 7580; Evocalcet |
| IUPAC Name | 2-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid |
| InChIKey | RZNUIYPHQFXBAN-XLIONFOSSA-N |
| InChI | InChI=1S/C24H26N2O2/c1-17(22-8-4-6-19-5-2-3-7-23(19)22)25-20-13-14-26(16-20)21-11-9-18(10-12-21)15-24(27)28/h2-12,17,20,25H,13-16H2,1H3,(H,27,28)/t17-,20+/m1/s1 |
| Canonical SMILES | O=C(O)CC1=CC=C(N2C[C@@H](N[C@@H](C3=C4C=CC=CC4=CC=C3)C)CC2)C=C1 |
| Chemical Name | Evocalcet |
| Formula | C24H26N2O2 |
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信息真实价格透明
资金保障
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产品应用
- Evocalcet is a calcium-sensing receptor agonist. The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. The calcium-sensing receptor controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). CaSR is expressed in all of the organs of the digestive system. CaSR plays a key role in gastrointestinal physiological function and in the occurrence of digestive disease. High dietary Ca2+ may stimulate CaSR activation and could both inhibit tumor development and increase the chemotherapeutic sensitivity of cancer cells in colon cancer tissues.
