3-(1-Cyano-1-Methylethyl)-N-[3-[(3,4-Dihydro-3-Methyl-4-Oxo-6-Quinazolinyl)Amino]-4-Methylphenyl]-Benzamide 3-(1-氰基-1-甲基乙基)-N-[3-[(3,4-二氢-3-甲基-4-氧代-6-喹唑啉基)氨基]-4-甲基苯基]苯甲酰胺
CAS 878739-06-1 MFCD78739061
化学结构图
SMILES: Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ccc2ncn(C)c(=O)c2c1
化学属性
| Mol. Formula | C27H25N5O2 |
|---|---|
| Mol. Weight | 452 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 3-(1-Cyano-1-Methylethyl)-N-[3-[(3,4-Dihydro-3-Methyl-4-Oxo-6-Quinazolinyl)Amino]-4-Methylphenyl]-Benzamide |
|---|---|
| Chemical Name Translation | 3-(1-氰基-1-甲基乙基)-N-[3-[(3,4-二氢-3-甲基-4-氧代-6-喹唑啉基)氨基]-4-甲基苯基]苯甲酰胺 |
| Chemicalbook ID | CB22516246 |
| Formula | C27H25N5O2 |
| Synonym | AZ628; AZ-628; AZ 628 |
| IUPAC Name | 3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide |
| InChIKey | ZGBGPEDJXCYQPH-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33) |
| Canonical SMILES | O=C(NC1=CC=C(C)C(NC2=CC3=C(N=CN(C)C3=O)C=C2)=C1)C4=CC=CC(C(C)(C#N)C)=C4 |
| MDL Number | |
| CAS Number | 878739-06-1 |
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产品应用
- AZ-628 is a selective, orally available Raf inhibitor with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies ( (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). AZ-628 inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
