N-(3-(5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl)-2,4-Difluorophenyl)Propane-1-Sulfonamide N-(3-(5-氯-1H-吡咯并[2,3-b]吡啶-3-羰基)-2,4-二氟苯基)丙烷-1-磺酰胺
CAS 918505-84-7 MFCD018505847
化学结构图
SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F
化学属性
| Mol. Weight | 413.82 |
|---|---|
| Mol. Formula | C17H14ClF2N3O3S |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 918505-84-7 |
|---|---|
| Chemical Name | N-(3-(5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl)-2,4-Difluorophenyl)Propane-1-Sulfonamide |
| Synonym | N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide PLX 4720 PLX 4720; PLX4720; PLX-4720. PLX-4720 PLX4720 |
| Chemical Name Translation | N-(3-(5-氯-1H-吡咯并[2,3-b]吡啶-3-羰基)-2,4-二氟苯基)丙烷-1-磺酰胺 |
| PubChem Substance ID | 24180719 |
| InChI | InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) |
| LabNetwork Molecule ID | LN01313514 |
| Formula | C17H14ClF2N3O3S |
| IUPAC Name | N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide |
| InChIKey | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| Canonical SMILES | CCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(Cl)C=C32)=O)=C1F)=O |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.
相关文献及参考
- Conner, S., et al.: J. Biol. Chem., 278, 34548 (2003),
- Dumaz, N., et al.: Cancer Res., 66, 9483 (2006),
- Salerno, P., et al.: J. Clin. Endocrinol. Metab., 95, 450 (2010),
