N-[[1,2-Dihydro-4-Hydroxy-2-Oxo-1-(Phenylmethyl)-3-Quinolinyl]Carbonyl]-Glycine 2-(1-苄基-4-羟基-2-氧代-1,2-二氢喹啉-3-甲酰胺基)乙酸
CAS 931398-72-0 MFCD22580424
化学结构图
SMILES: O=C(O)CNC(=O)c1c(O)c2ccccc2n(Cc2ccccc2)c1=O
化学属性
| Mol. Formula | C19H17N2O4 |
|---|---|
| Mol. Weight | 352.34 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-[[1,2-Dihydro-4-Hydroxy-2-Oxo-1-(Phenylmethyl)-3-Quinolinyl]Carbonyl]-Glycine |
|---|---|
| Chemical Name Translation | 2-(1-苄基-4-羟基-2-氧代-1,2-二氢喹啉-3-甲酰胺基)乙酸 |
| Chemicalbook ID | CB32638323 |
| Formula | C19H16N2O5 |
| Synonym | IOX2; IOX-2; IOX 2 |
| IUPAC Name | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| InChIKey | CAOSCCRYLYQBES-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23) |
| Canonical SMILES | O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O |
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资金保障
专业采购外包团队在线服务
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产品应用
- IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.
相关文献及参考
- [2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50.
- [1]. Chowdhury R, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
- [1]. Chowdhury R, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96.
- [2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50.
