Trifluoroacetic anhydride 三氟乙酸酐
CAS 407-25-0 MFCD00000416
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Building Blocks, Carbonyl Compounds, Carboxylic Acid Anhydrides, Chemical Synthesis, Organic Building Blocks
- {uni_hamburg} no charge; carbo-anhydride; 1fragment
- Acylation Reagents, Analytical Reagents, Analytical/Chromatography, Avermectine Drugs, Derivatization Reagents, Derivatization Reagents GC, Derivatization Reagents HPLC, HPLC Derivatization Reagents, by Application, Reagents for Acylation
- {SNA} Acylation Reagents, Avermectine Drugs, Derivatization Reagents, Derivatization Reagents GC, Derivatization Reagents HPLC, HPLC Derivatization Reagents, by Application, Reagents for Acylation, 分析/色谱, 分析试剂
- {Chemicalbook} 农药中间体: 杀虫剂中间体: 其他杀虫剂
产品应用
- 用作分析试剂、溶剂、催化剂、硝化反应促进剂、脱水缩合剂、羟基和氨基三氟乙酰化时的保护剂 ,有机合成。气相色谱分析中生物活性化合物。伯胺、仲胺的保护剂。也用于醛类氧化成酸类、酯类和胺类。
- 衍生级用于保护伯胺和仲胺。衍生化物更易挥发。
相关文献及参考
- For the ɑ-trifluoroacetylation of a phosphonium salt in a route to perfluoroalkyl acetylenes, see: Org. Synth. Coll., 9, 436 (1998). For reaction scheme, see (Ethoxycarbonylmethyl)triphenylphosphonium bromide, A16347.
- In pyridine, de
- Beilstein:2(2)186
- Alternative to Oxalyl chloride, A18012, for activation of Dimethyl sulfoxide, A13280 in th
- Mild conversion of aryl halides to aryl trifluoromethyl ketones via Pd catalyzed stannylation: Synlett, 165 (1995).
- In pyridine, dehydrates carboxamides or aldoximes to nitriles: Tetrahedron Lett., 1813 (1977); Synthesis, 56, (1979). With triethylamine, effects the dehydration of aldols to enones, where other methods are less successful: Org. Synth. Coll., 8, 210 (1993).
- In pyridine and dichloromethane or ether, converts acid chlorides to trifluoromethyl ketones in good yields via a trifluoroacyl ketene intermediate: Tetrahedron, 51, 2573 (1995). The method has been extended to the synthesis of a range of trifluoromethylated heterocycles: Tetrahedron, 51, 2585 (1995):
- Trifluoroacetyl esters are rapidly hydrolyzed at pH 7: Tetrahedron Lett., 1039 (1963). Trifluoroacetamides are also readily hydrolyzed e.g. by mild base; selective cleavage of a trifluoroacetamide can be achieved in the presence of a methyl ester: J. Org. Chem., 54, 2498 (1989). For the racemization-free removal of the N-trifluoroacetyl group from peptides by NaBH4, see: Chem. Ber., 103, 2437 (1970).
- Trifluoroacetylating agent for protection of alcohols and amines: Helv. Chim. Acta., 37, 443 (1954); Tetrahedron, 43, 5583 (1987); Tetrahedron Lett., 28, 4737 (1987), useful, e.g. as volatile derivatives in GC: J. Chromat., 43, 129 (1969); 61, 225 (1971); 93, 223, 447 (1974); D. R. Knapp, Handbook of Analytical Derivatisation Reactions, Wiley, N.Y. (1979); Handbook of Derivatives for Chromatography, 2nd ed., K. Blau and J. M. Halket, Eds., Wiley, Chichester (1993).
安全信息
GHS Symbol
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H332 Harmful if inhaled 吸入有害
- H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P301+P330+P331+P310
- P303+P361+P353
- P303+P361+P353+P310+P363
- P304+P312
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R14 Reacts violently with water 遇水会猛烈反应
- R20 Harmful by inhalation 吸入有害
- R35 Causes severe burns 会导致严重灼伤
- R52/53
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
其他信息
- 有刺激性气味,易挥发。有吸湿性。遇水和乙醇分解。溶于乙醚和乙酸。中等毒,半数致死量(大鼠,经口)100mg/kg。有腐蚀性。
- 三氟乙酸酐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80134826 三氟乙酸酐(*) 100ml 319.4元 2011/08/23 K9171902 三氟乙酸酐 (+4℃) 10ml 595元 2011/04/16 T0433 三氟乙酸酐 Trifluoroacetic Anhydride 20ML 280元
- 图谱信息:三氟乙酸酐(407-25-0)核磁图( 13 CNMR) 三氟乙酸酐(407-25-0)质谱(MS) 三氟乙酸酐(407-25-0)红外图谱(IR1)
- TCI Shanghai:三氟乙酸酐 Trifluoroacetic Anhydride,>;98.0%(GC)(407-25-0)
- Trifluoroacetic anhydride is used for the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for GC analysis. Also used in the oxidation of aldehydes to acids, amides or esters. Strong non-oxidizing acid, laboratory reagent, solvent, catalyst.
- Hazard N
- 可燃性危险特性:催泪; 遇水分解有毒氟化物气体; 燃烧产生有毒氟化物烟雾
- Sigma Aldrich:407-25-0(sigmaaldrich)
- 上游原料:三氟乙酸 --> 二
- F:3-10
- 方法一:其制备方法是用三氟乙酸与二氯乙酸酐反应。反应方程式:CF 3 COOH+(Cl 2 CHCO) 2 O→(CF 3 CO) 2 O+Cl 2 CHCOOH
- 下游产品:虫螨腈 --> 2-氯-4-三氟甲基嘧啶 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲醛 --> (2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-基)甲胺 --> 2-(4-羟基哌啶-1-基)-6-三氟甲基嘧啶-4-甲酸乙酯 --> 1-甲基-3-三氟甲基-1H-吡唑 --> 2-(4-羟甲基哌啶-1-基)-6-三氟甲基嘧啶-4-甲酸乙酯 --> 3-氯-5-氟苯胺 --> 5-氨基-3-三氟甲基-4-吡唑甲酸乙酯 --> 5-溴-2-羟甲基吡啶 --> 3-硝基-4-吡啶羧酸 --> 2-(4-乙氧基羰基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲酸乙酯 --> 5-溴-2-吡啶甲醛 --> 4-(4-三氟甲基嘧啶-2-基)哌嗪-1-甲酸叔丁酯 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲腈 --> 2-羟基-6-三氟甲基烟酸 --> (2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-基)甲醇 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲酰胺 --> 5-硝基-3-氯吡啶 -->
- 外观性质:无色液体, 有刺激性气味, 易挥发。
- 海关编码:29159080
- 灭火剂:干砂、干石粉
- 用途四:用作分析试剂、溶剂、催化剂、硝化反应促进剂、脱水缩合剂、羟基和氨基三氟乙酰化时的保护剂 ,有机合成。气相色谱分析中生物活性化合物。伯胺、仲胺的保护剂。也用于醛类氧化成酸类、酯类和胺类。
- 类别:腐蚀物品
- 用途二:用作农药中间体
- TSCA:T
- 用途四:用作分析试剂、溶剂、催化剂、硝化反应促进剂、脱水缩合剂、羟基和氨基三氟乙酰化时的保护剂 ,有
- 用途一:用作分析试剂、溶剂、催化剂、脱水缩合剂与羟基和氨基三氟乙酰化时的保护剂
- 刺激数据:皮肤- 兔子 0.75 毫克/ 24小时 重度; 眼- 兔子 5 毫克/ 24小时 重度