CAS 2234-16-4 MFCD00000581-2',4'-Dichloroacetophenone 2,4-二氯苯乙酮 TAO{mole}

2',4'-Dichloroacetophenone 2,4-二氯苯乙酮

CAS 2234-16-4 MFCD00000581

化学结构图

SMILES: CC(=O)c1ccc(Cl)cc1Cl

化学属性

Mol. Formula	C8H6Cl2O
Mol. Weight	189.04
Density	1.320
Refractive index	n20/D 1.5635(lit.)
Flash Point	113°C
TSCA	Yes
Boiling Point	246.7°C at 760 mmHg
Melting Point	33-34°C
Solubility	CA. 200 MG/L
Appearance	1.5635，不溶于水，溶于苯、甲苯、醇等有机溶剂。 2，4-二氯苯乙酮为白色结晶体，m.p.33～34℃，b.p.128～131℃/2.4kpa，n D 20

别名和识别编码

Chemical Name	2',4'-Dichloroacetophenone
CAS Number	2234-16-4
Alfabeta Name	DICHLOROACETOPHENONE 24-,''
MDL Number	MFCD00000581
EC Number	218-780-8
Beilstein Registry Number	637819
PubChem Substance ID	16693
Synonym	2',4'-Dichloroacetophenone {LY} 2',4'-Dichloroacetophenone {} {LY} 2',4'-Dichloroacetophenone {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichloroacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dichl
Chemical Name Translation	2,4-二氯苯乙酮
Reaxys-RN	637819
LabNetwork Molecule ID	LN00174552
InChI	InChI=1S/C8H6Cl2O/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3
Canonical SMILES	C1=C(C(=CC=C1Cl)C(C)=O)Cl

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安全信息

Warnings IRRITANT

Signal word

GHS Symbol

WGK Germany2

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S39 Wear eye/face protection 戴眼睛/面孔保护装置；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R52/53
R22 Harmful if swallowed 吞咽有害
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P308+P313
P332+P313
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350
P337+P313
P305+P351+P338

Hazard statements

H318 Causes serious eye damage 严重伤害眼睛
H302 Harmful if swallowed 吞食有害
H302+H312+H332

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn Xn,Xi

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

Acros Organics:2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone, 98.50%(2234-16-4)
Alfa Aesar:2',4'-二氯苯乙酮,98% 2',4'-Dichloroacetophenone, 98%(2234-16-4)
下游产品:伊曲康唑
用途一:用作医药中间体，用于合成酮康唑药物
Hazard Note:Irritant
2,4-二氯苯乙酮价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D1490 2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone 500G 2090元 2014/06/02 D1490 2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone 25G 502元 2010/06/21 302430250 2,4-二氯苯乙酮 2',4'-Dichloroacetophenone 97% 25 GR 471元
图谱信息:2,4-二氯苯乙酮(2234-16-4)质谱(MS) 2,4-二氯苯乙酮(2234-16-4)红外图谱(IR1) 2,4-二氯苯乙酮(2234-16-4)核磁图( 1 HNMR) 2,4-二氯苯乙酮(2234-16-4)Raman光谱 2,4-二氯苯乙酮(2234-16-4)核磁图( 13 CNMR)
MOL 文件:2234-16-4.mol
TCI Shanghai:2',4'-二氯苯乙酮 2',4'-Dichloroacetophenone,>;98.0%(GC)(2234-16-4)
MSDS 信息:2',4'-Dichloroacetophenone(2234-16-4).msds
方法一:其制备方法是在反应瓶中加入间二氯苯，升温至50℃，搅拌下加入适量的无水三氯化铝，保持温度50℃，滴加乙酰氯，滴完后逐渐升温至100℃，并在该温度下搅拌8h，反应结束后，在反应液中加入二氯甲烷并倒入水中，放置冷却，分出油层，水层用二氯甲烷萃取，并入有机层，用水洗涤有机层，干燥，蒸去溶剂减压蒸馏，收集160～180℃/0.015 MPa馏分，得到白色结晶为2，4-二氯苯乙酮。
用途二:2，4-二氯苯乙酮是制备ω-溴-2，4-二氯苯乙酮或ω-2，4-三氯苯乙酮的原料，后两者是制备抑霉唑、丙环唑、乙环唑等杀菌剂的中间体，也是杀虫剂毒虫畏、除草剂野燕枯的中间体。
上游原料:二氯甲烷 --> 三氯化铝 --> 乙酰氯 --> 1,3-二氯苯
用途三:酮康唑的中间体。