CAS 637-07-0 MFCD00000615-Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate 氯贝丁酯 TAO{mole}

Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate 氯贝丁酯

CAS 637-07-0 MFCD00000615

化学结构图

SMILES: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

化学属性

Mol. Formula	C12H15ClO3
Mol. Weight	243
Density	1.137
Boiling Point	154-156
Refractive index	1.5000 to 1.5050
Flash Point	113 °C
Appearance	liquid 无色或黄色透明油状液体，略及异臭。不溶于水，可溶于乙醇、丙酮、氯仿、乙醚。沸点148-150℃（2.67kPa）。

别名和识别编码

Chemical Name	Ethyl 2-(4-Chlorophenoxy)-2-Methylpropanoate
MDL Number	MFCD00000615
CAS Number	637-07-0
Synonym	(p-chlorophenoxy)dimethyl-aceticaciethylester 2-(4-CHLOROPHENOXY)-2-METHYLPROPIONIC ACID ETHYL ESTER 2-(4-CHLOROPHENOXY)ISOBUTYRIC ACID ETHYL ESTER 2-(4-Chlorophenoxy)-2-methylpropionic 2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate 2-(4-chlorophen 2-(p-Chlorophenoxy)isobutyric acid ethyl ester Apolan At Ateriosan Atromid S Atromida Cloberat Clobrat Clobren-SF Clofibrat Clofipront Dura clofibrat EPIB Ethyl alpha-(4-chlorophenoxy)isobutyrate Hyclorate Klofiran Liponorm Neo-atromid Normolipol Ticlobran alpha-(p-chlorophenoxy)isob
Beilstein Registry Number	1913459 1913459
PubChem Substance ID	2796
EC Number	211-277-4
Chemical Name Translation	氯贝丁酯
Reaxys-RN	1913459
Merck Number	2377
Wiswesser Line Notation	GR DOX1&1&VO2
LabNetwork Molecule ID	LN00198126
InChI	InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

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安全信息

GHS Symbol

WGK Germany3

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H318 Causes serious eye damage 严重伤害眼睛
H302 Harmful if swallowed 吞食有害
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSUE9480000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Hazard Codes 9

Risk Statements

R22 Harmful if swallowed 吞咽有害
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R51/53

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Storage condition 2-8°C 储存温度2-8°C

UN Number 3082

Packing GroupIII

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 gm/kg/72W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
   Liver - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,3419,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1370 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   4,140,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1220 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/pa

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2041937

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Po

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   60,131,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 gm/L
REFERENCE :
   TUMOAB Tumori.  (Casa Editrice Ambrosiana, Via G. Frua 6, 20146 Milan,
   Italy)  V.1-    1911-  Volume(issue)/page/year: 77,105,1991

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 pmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,1547,1984

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 100 umol/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 8,1433,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CUSCAM Current Science.  (Current Science Assoc., Sadashivanagar P.O.,
   Bangalore 560 080, India) V.1-    1932-  Volume(issue)/page/year:
   57,364,1988

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg/15D (Continuous)
REFERENCE :
   CUSCAM Current Science.  (Current Science Assoc., Sadashivanagar P.O.,
   Bangalore 560 080, India) V.1-    193

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 31,1831,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3960 mg/kg
SEX/DURATION            : male 22 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 160,405,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 gm/kg
SEX/DURATION            : female 2 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Resea

其他信息

储运特性:通风低温干燥
急性毒性:口服-大鼠 LD50: 940 毫克/公斤; 口服-小鼠 LD50: 1220 毫克/公斤
Acros Organics:氯贝丁酯 ethyl 2-(4-chlorophenoxy)-2-methylpropanoate(637-07-0)
毒性分级:中毒
color:clear, colorless
Sigma Aldrich:637-07-0(sigmaaldrich)
图谱信息:氯贝特(637-07-0)质谱(MS) 氯贝特(637-07-0)红外图谱(IR1)
氯贝特价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 C0941 氯贝丁酯 Clofibrate 25G 344元 2014/06/02 C0941 氯贝丁酯 Clofibrate 500G 3200元 2010/06/21 RDP00167EB 氯贝特 ethyl 2-(4-chlorophenoxy)-2-methylpropanoate 25 GR 420元
可燃性危险特性:可燃;燃烧产生有毒氯化物烟雾;病人用药副作用为:肌肉无力,肌肉痉挛,发烧
MOL 文件:637-07-0.mol
用途一:用于脑血栓、脑动脉硬化、脑外伤后遗症、内耳眩晕症、冠状动脉硬化及由末梢循环不良引起的疾病
上游原料:4-氨基苯酚 --> 肉桂醇 --> 4-氯苯氧异丁酸
MSDS 信息:Ethyl 2-(4-chlorophenoxy)-2-methylpropionate(637-07-0).msds
灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
类别:有毒物品
用途三:降血脂药。能抑制胆固醇和甘油三酯的合成，增加固醇类的排泄，降低血中ULDL的含量，临床证明该品降甘油三酯作用较降胆醇作用明显，作用强时甘油三酯可降低30-40%，胆固醇可降低15-20%，适用于Ⅲ、Ⅳ、Ⅴ型高血酯症，对Ⅲ型尤佳，对部分Ⅱb型也有效，此外，该品能降低血浆纤维蛋白元的含量和血小板的粘性，因而，有利于防止血栓的形成，减少心肌梗塞的发病率，用于高酯血症及动脉硬化症等。服用该品个别病人有恶心、呕吐、食欲不振、腹胀、腹泻等症状。为了减少胃肠道反应，开始时宜采用小剂量，以后逐渐增量，但在治疗的第一个月应达到规定剂量。停药时最好也采用递减方法。肝肾功能不全者慎用。孕妇忌用。毒性：口服LD50小鼠1.28g/kg；大鼠1.65g/kg。
方法一:按照采用的原料划分，该品合格路线主要有两条，一是以对氨基苯酚为原料经重氮化、置换制得对氯苯酚，再经缩合、水解，酸化生成对氯苯氧异丁酸，最后酯化得安妥明。这条路线步骤较长，所用原料对氨基酚不稳定，但比较成熟。二是以苯酚为原料，经缩合生成苯氧异丁酸，再于乙醇中通氯，进行氯化及酯化反应生成安妥明。
用途二:主要用于治疗高脂蛋白血症
TCI Shanghai:2-(4-氯苯氧基)异丁酸乙酯 Clofibrate,>;95.0%(T)(637-07-0)