Isobutyl Chloroformate 氯甲酸异丁酯
CAS 543-27-1 MFCD00000642
化学结构图
SMILES: CC(C)COC(=O)Cl
化学属性
| Mol. Formula | C5H9ClO2 |
|---|---|
| Mol. Weight | 137 |
| Density | 1.053 |
| Refractive index | 1.4060 to 1.4080 |
| Boiling Point | 129 |
| Vapor Pressure | 0.33 mmHg ( 20 °C) |
| Flash Point | 35°C(lit.) |
| TSCA | Yes |
| Melting Point | -80°C |
| Solubility | 溶于热乙醇、苯、氯仿，可混溶于乙醚。 |
| Stability | 对湿度和热敏感 |
| Danger-Level | 甲类 |
别名和识别编码
| Chemical Name | Isobutyl Chloroformate |
|---|---|
| Synonym | iso-butyl chloroformate 氯甲酸異丁酯 chlorocarbonicacidisobutylester ISOBUTYL CHLOROCARBONATE 氯碳酸異丁酯 isobutyl chloformate Carbonochloridic acid, 2-methylpropyl ester 氯代甲酸异丁酯 ISOBUTYL CHLOROFORMATE 异丁基氯甲酸酯;氯代甲酸异丁酯;氯甲酸-2-甲基丙基酯;氯碳酸异丁酯;氯蚁酸异丁酯 Isobutyl chloridocarbonate IBCF Isobutoxycarbonyl chloride Isobutyl chloroformate 98% Isobutyl chlorocarbonate 2-methylpropyl chloroformate #niso-Butyl chloroformate 氯甲酸-2-甲基丙基酯 NSC 8429 2-methyl-1-propylchlorocarbonate Isobutyloxycarbonyl chloride 氯代甲酸异丁酯(0404仍禁运) Isobutylchloroformate,~90% 2-methylpropylchloroformate Isobutyl-chlorformiat Isobutylchloroformate99% CHLOROFORMIC ACID ISOBUTYL ESTER carbonochloridic acid isobutyl ester Isobutylchlorformiat Carbonochloridic acid 2-methylpropyl- Chlorocarbonic acid isobutyl ester 氯碳酸异丁酯 2-Methylpropyl chloroformate Chloroformic acid isobutyl ester Isobutylchloroformiat Carbonochloridic acid 2-methylpropyl ester; Isobutyl chlorocarbonate Isobutyl chloroformate 异丁基氯甲酸酯 chlorocarbonic acid isobutyl ester 2-Methylpropyl carbonochloridate 氯甲酸异丁酯 Isobutyl chloocarbonate 2-methyl-1-propyl chlorocarbonate Formic acid, chloro-, isobutyl ester 氯蚁酸异丁酯 Chlorameisensäureisobutylester Isobutylchloroformate,98% carbonochloridic acid 2-methylpropyl ester |
| MDL Number | MFCD00000642 |
| CAS Number | 543-27-1 |
| EC Number | 208-840-1 |
| Beilstein Registry Number | 193698 |
| PubChem Substance ID | 62365 |
| Merck Number | 5139 |
| Reaxys-RN | 956590 |
| Chemical Name Translation | 氯甲酸异丁酯 |
| LabNetwork Molecule ID | LN00194865 |
| InChI | InChI=1S/C5H9ClO2/c1-4(2)3-8-5(6)7/h4H,3H2,1-2H3 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {uni_hamburg} no charge; carbonyl chloride; 1fragment
- {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
产品应用
- 用于有机合成。
相关文献及参考
- Merck:14,5139
- Short: III/20a
- Merck:14,5139 Beilstein:3,12
- Has been used to protect a nucleoside OH group as its isobutyl carbonate. Cleavage was by hydrolysis with 80% AcOH: J. Org. Chem., 32, 2365 (1967). Protection of amino groups as their isobutyl carbamates has also been reported: J. Am. Chem. Soc., 91, 3356 (1969).
- Short: II/14a
- Short: III/38B
- Superior to ethyl chloroformate in the mixed anhydride method of peptide synthesis: Org. Prep. Proced. Int., 7, 215 (1975); review: Org. React., 12, 157 (1962). Use in combination with 1-Methylpiperidine, L03398, minimizes competing urethane formation, arising from cleavage of the mixed anhydride in the wrong sense: J. Org. Chem., 48, 2939 (1983). Addition of CuCl2 is reported to suppress racemization completely: Chem. Lett., 2125 (1989). For peptide reagents, see Appendix 6.
安全信息
GHS Symbol
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
- R10 Flammable 易燃
- R22 Harmful if swallowed 吞咽有害
- R23 Toxic by inhalation 吸入有毒
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241+P242+P243
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P330+P331+P310
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P370+P378
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H331 Toxic if inhaled 吸入中毒
- H302 Harmful if swallowed 吞食有害
其他信息
- 氯甲酸异丁酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80025282 氯甲酸异丁酯;氯蚁酸异丁酯;氯碳酸异丁酯 100g 95元 2011/04/16 C0178 氯甲酸异丁酯 Isobutyl Chloroformate 25G 155元 2011/04/16 C0178 氯甲酸异丁酯 Isobutyl Chloroformate 500G 960元
- Alfa Aesar:氯甲酸异丁酯,98% Isobutyl chloroformate, 98%(543-27-1)
- 存储注意事项:氮气保护;湿度敏感
- Sigma Aldrich:543-27-1(sigmaaldrich)
- 下游产品:头孢匹胺
- 外观性质:无色液体, 有刺激性气味。
- 有刺激性气味，蒸汽压0.87kPa/20℃，溶于热乙醇、苯、氯仿，可混溶于乙醚。
- MSDS 信息:氯甲酸异丁酯(543-27-1).msds
- MOL 文件:543-27-1.mol
- F:10-19
- 有刺激性气味，蒸汽压0.87kPa/20℃，，溶于热乙醇、苯、氯仿，可混溶于乙醚。
- 用途一:用于有机合成
- 图谱信息:氯甲酸异丁酯(543-27-1)质谱(MS) 氯甲酸异丁酯(543-27-1)核磁图( 13 CNMR) 氯甲酸异丁酯(543-27-1)核磁图( 1 HNMR) 氯甲酸异丁酯(543-27-1)红外图谱(IR1)
- 检测方法:GC,NMR
- 敏感性:Moisture Sensitive
- Acros Organics:氯代甲酸异丁酯（禁运） Isobutyl chloroformate, 98%(543-27-1)
- 蒸气压:0.33 mm Hg ( 20 °C)
