O-Acetylsalicyloyl Chloride 邻乙酰水杨酰氯
CAS 5538-51-2 MFCD00000663
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
相关文献及参考
- Reagent for the conversion of diols into chloroalkyl acetates: Tetrahedron Lett., 1475 (1973), and for the conversion of pyrimidine nucleosides to their 2,2'-anhydro derivatives: Synthesis, 533 (1976). Compare 2-Acetoxyisobutyryl chloride, L00957.
安全信息
GHS Symbol
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H302 Harmful if swallowed 吞食有害
- P303+P361+P353+P310+P363
- P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P405 Store locked up. 上锁保管。
- P305+P351+P338
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P304+P340+P310
- P303+P361+P353
- P234 Keep only in original container. 只保留在原来的容器中。
- P305+P351+P338+P310
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P301+P330+P331+P310
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R34 Causes burns 会导致灼伤
- R37 Irritating to respiratory system 刺激呼吸道
- R22 Harmful if swallowed 吞咽有害
- R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
其他信息
- 方法一:以乙酰水杨酸为原料,经氯化而得。将1份乙酰水杨酸和0.0055份吡啶加入干燥的反应罐中,控温50℃以下滴加0.91份氯化亚砜。升温至90℃,反应物溶解成黄色时,继续反应2.5h。90-100℃减压蒸去过量的氯化亚砜和吡啶,得邻乙酰氧基苯甲酰氯。收率95%。另一种方法也以乙酰水杨酸和氯化亚砜为原料,但采用无水三氯化铝,在无水苯中反应3h,第一小时50-55℃,第二小时60-65℃,第三小时73-79℃。配料(重量)比为:乙酰水杨酸:氯化亚砜:三氯化铝:苯=1:0.56:0.02:3。收率91%以上。
- 用途一:用作医药中间体
- 上游原料:无水苯 --> 邻乙酰水杨酸
- 用途三:医药中间体,用于生产抗血凝药新抗凝,激素类抗炎药及治疗风温、抗炎、解热镇痛药扑炎痛等。
- Sigma Aldrich:5538-51-2(sigmaaldrich)
- 敏感性:Moisture Sensitive
- 用途二:医药中间体。用于生产抗血凝药新抗凝,激素类抗炎药及治疗风温、抗炎、解热镇痛药扑炎痛等。
- Hazard Note:Irritant/Corrosive/Moisture Sensitive
- TCI Shanghai:O-乙酰基水杨酰氯 O-Acetylsalicyloyl Chloride,>;97.0%(LC)(T)(5538-51-2)
- Acros Organics:邻乙酰水杨酰氯 Acetylsalicyloyl chloride, 98%(5538-51-2)
- Alfa Aesar:O-乙酰基水杨酰氯,97% O-Acetylsalicyloyl chloride, 97%(5538-51-2)
- MOL 文件:5538-51-2.mol
- 下游产品:4-羟基香豆素 --> 4-羟基肉桂酸 --> 2-乙酰氧基苯甲酸-4-乙酰氨基苯酯
- F:3-10-21