Chlorodifluoroacetic Acid Methyl Ester 氯二氟乙酸甲酯

CAS 1514-87-0 MFCD00000775

化学结构图

1514-87-0
SMILES: COC(=O)C(F)(F)Cl

化学属性

Mol. FormulaC3H3ClF2O2
Mol. Weight144.50
Refractive index1.3480 to 1.3510
Boiling Point79-81°C at 760 mmHg
Density1.37
Flash Point19°C
TSCAYes
Stability对湿度敏感

别名和识别编码

Chemical NameChlorodifluoroacetic Acid Methyl Ester
CAS Number1514-87-0
PubChem Substance ID73935
EC Number216-154-9
Beilstein Registry Number1756072
MDL NumberMFCD00000775
Reaxys-RN1756072
Synonym Chlorodifluoroacetic acid methyl ester {LY} Chlorodifluoroacetic acid methyl ester {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl ester {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorodifluoroacetic acid methyl
Chemical Name Translation氯二氟乙酸甲酯
InChIKeyAWUPLMYXZJKHEG-UHFFFAOYSA-N
LabNetwork Molecule IDLN00222918
InChIInChI=1S/C3H3ClF2O2/c1-8-2(7)3(4,5)6/h1H3
Canonical SMILESO=C(OC)C(F)(Cl)F
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分类

  • {SA} Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks
  • {SNA} Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluori
  • Alkyl Fluorinated Building Blocks, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Fluorinated Building Blocks, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks

产品应用

  • Used in preparation of gem-difluorocyclopropane.2 and 2,2-difluoro-3-hydroxyesters1

相关文献及参考

  • Convenient trifluoromethylating agent. In combination with CuI, KF and DMF, trifluoromethylation of aryl and vinyl halides is achieved via the generation of trifluoromethylcopper: Tetrahedron Lett., 32, 7689 (1991); J. Fluorine Chem., 55, 225 (1992). Similarly, nitroaryl chlorides undergo substitution to give the trifluoromethyl derivatives in high yield: J. Fluorine Chem., 66, 167 (1994).
  • Convenient trifluoromethylating agent. In combination with CuI, KF and DMF, trifluoromethylation of aryl and vinyl halides is achieved via the generation of trifluoromethylcopper: Tetrahedron Lett., 32, 7689 (1991); J. Fluorine Chem., 55, 225 (1992). Similarly, nitroaryl chlorides undergo substitution to give the trifluoromethyl derivatives in high yield: J. Fluorine Chem., 66, 167 (1994).

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3 F,C
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R11 Highly flammable 非常易燃
  • R34 Causes burns 会导致灼伤
  • R37 Irritating to respiratory system 刺激呼吸道
UN Number 2924 UN2924
Storage condition -20°C {LY} -20°C Flammables area Moisture Sensitive {} {LY} -20°C {} {} {LY} -20°C {} {} {} {LY} -20°C {} {} {} {} {LY} -20°C {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Packing GroupII
Hazard Class3/8

其他信息

  • TCI Shanghai:氯二氟乙酸甲酯 Methyl Chlorodifluoroacetate,>;96.0%(GC)(1514-87-0)
  • F:19
  • Alfa Aesar:氯代二氟乙酸甲酯,98% Methyl chlorodifluoroacetate, 98%(1514-87-0)
  • Chlorodifluoroacetic acid methyl ester is a trifluoromethylating agent.3
  • Acros Organics:2-氯-2,2-二氟乙酸甲酯 Methyl 2-chloro-2,2-difluoroacetate, 99%(1514-87-0)
  • 敏感性:Moisture Sensitive
  • Hazard Note:Highly Flammable/Moisture Sensitive
  • 2-氯-2,2-二氟乙酸甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1586 氯二氟乙酸甲酯 Methyl Chlorodifluoroacetate 5G 245元 2014/06/02 C1586 氯二氟乙酸甲酯 Methyl Chlorodifluoroacetate 25G 645元 2010/06/21 308010250 2-氯-2,2-二氟乙酸甲酯 Methyl 2-chloro-2,2-difluoroacetate 99% 25 GR 733元
  • MOL 文件:1514-87-0.mol
  • 图谱信息:2-氯-2,2-二氟乙酸甲酯(1514-87-0)核磁图( 13 CNMR) 2-氯-2,2-二氟乙酸甲酯(1514-87-0)核磁图( 1 HNMR) 2-氯-2,2-二氟乙酸甲酯(1514-87-0)质谱(MS)

系列性分类


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