Bromodichloromethane 溴代二氯甲烷

CAS 75-27-4 MFCD00000824

化学结构图

75-27-4
SMILES: ClC(Cl)Br

化学属性

Mol. FormulaCHBrCl2
Mol. Weight163.83
Refractive index1.4940 to 1.4980
Boiling Point87 °C at 760 mmHg
Density1.98 g/mL at 25 °C(lit.)
Melting Point-55 °C
TSCAYes
Flash Point87-89°C
Stability对光敏感

别名和识别编码

Chemical NameBromodichloromethane
CAS Number75-27-4
Synonym Bromodichloromethane {LY} Bromodichloromethane {} {LY} Bromodichloromethane {} {} {LY} Bromodichloromethane {} {} {} {LY} Bromodichloromethane {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bromodichloromethane {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00000824
PubChem Substance ID6359
EC Number200-856-7
Beilstein Registry Number1,67
Merck Number1417
Reaxys-RN1697005
Chemical Name Translation溴代二氯甲烷
Wiswesser Line NotationGYGE
LabNetwork Molecule IDLN01284299
InChIInChI=1S/CHBrCl2/c2-1(3)4/h1H
Canonical SMILESClC(Cl)Br
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分类

  • Mutagenesis Research Chemicals
  • {SNA} A-B, Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Applications, B, BI - BZ, Bromo, Chemical Class, Chloro, Chromatography, Disinfection Byproducts, Disinfection Product Residues and Solvents, Environmental Standards, Food & Beverage Analysis, Halogenated, Processing/Packaging Contaminants, Volatiles/ Semivolatiles, Waste water
  • {SNA} Alkyl, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, Organic Building Blocks
  • {uni_hamburg} no charge; 1fragment
  • Miscellaneous Reagents

产品应用

  • Usually used to investigate the in vivo genotoxicity of chlorodibromomethane, bromodichloromethane and bromoform in mice.

相关文献及参考

  • Nestmann, E.R. et al.: Water Chlorin. Env. Impact Health. Eff., 4, 1151 (1983); Hargesheimer, E.E. et al.: Am. J. Water Works Assoc., 40, 631 (1985); Stanaback, R.J.: Tech. Pap. Soc. Plast. Engin., 23
  • Merck: 14,1417 Beilstein: 1,IV,76
  • Short: II/27B
  • Short: II/25B
  • Merck: 14,1417
  • Source of dichlorocarbene, on treatment with base.

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H351 Suspected of causing cancer 怀疑致癌
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSPA5310000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P302+P352
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P337+P313
  • P403+P233
  • P303+P361+P353
  • P201 Obtain special instructions before use. 使用前获取专门指示。
Signal word Danger
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/39 Wear suitable protective clothing and eye/face protection 穿戴适当的防护服和眼睛/面保护;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Hazard Codes Xn Xn,T,F
Storage condition 0-10 0-10°C 0-6°C 2-8℃避光保存。 储存温度2-8℃ 储存温度2-8℃,充氩保存
UN Number 2810 1230
Packing GroupII
Hazard Class3/6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25500 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25500 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38250 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-321,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Liver - other changes
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
   Liver - fatty liver degeneration
   Blood - hemorrhage
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,213,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   TECSDY Toxicological and Environmental Chemistry.  (Gordon & Breach Science
   Pub. Inc., 1 Park Ave., New York, NY 10016)  V.3(3/4)-    1981-
   Volume(issue)/page/year: 13,205,1987

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg/4D (Intermittent)
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 32,72,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 180 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,91,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 400 umol/L
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 mg/plate
REFERENCE :
   DHEFDK HEW Publication (FDA. United States).  (Washington, DC)  ?-1979(?).
   For publisher information, see HPFSDS.  Volume(issue)/page/year:
   FDA-78-1046,1978

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 164 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(iss

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 750 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   40,30,1997

其他信息

  • 一溴二氯甲烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B1011 溴代二氯甲烷(含稳定剂乙醇) Bromodichloromethane (stabilized with Ethanol) 25G 680元 2014/06/02 S0635 一溴二氯甲烷(1mg/ml的甲醇溶液)[用于水分析] Bromodichloromethane (1mg/ml in Methanol) [for Water Analysis] 1ML 240元 2010/06/21 160700500 一溴二氯甲烷 Bromodichloromethane 98+%, stabilized 50 ML 1396元
  • 类别:有毒物质
  • Sigma Aldrich:75-27-4(sigmaaldrich)
  • 毒性分级:中毒
  • 挥发性有机化合物(VOCs)单组分标准液 US EPA方法:502.2,524.2,8021,8021A,8021B,624,8240B,8260B
  • 图谱信息:一溴二氯甲烷(75-27-4)质谱(MS) 一溴二氯甲烷(75-27-4)核磁图( 1 HNMR) 一溴二氯甲烷(75-27-4)Raman光谱 一溴二氯甲烷(75-27-4)核磁图( 13 CNMR) 一溴二氯甲烷(75-27-4)红外图谱(IR1)
  • F:8
  • 难溶于水,溶于乙醇、丙酮、苯、氯仿、DMSO和乙醚等有机溶剂。
  • MOL 文件:75-27-4.mol
  • TCI Shanghai:一溴二氯甲烷(1mg/ml的甲醇溶液)[用于水分析] Bromodichloromethane (1mg/ml in Methanol) [for Water Analysis](75-27-4)
  • 外观性质:无色液体。难溶于水,溶于醇、苯、醚等有机溶剂。折光率:1.497熔点:-55 °C沸点:87 °C密度:1.98
  • 挥发性有机化合物(VOCs)单组分标准液
  • 急性毒性:口服-大鼠 LD50: 916 毫克/公斤
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 储运特性:库房通风低温干燥
  • Acros Organics:一溴二氯甲烷 Bromodichloromethane, stabilized, 98+%(75-27-4)
  • 可燃性危险特性:热分解有毒溴化物和氯化物烟雾
  • Alfa Aesar:溴二氯代甲烷,98%,碳酸钾做稳定剂 Bromodichloromethane, 98%, stab. with potassium carbonate(75-27-4)

系列性分类