CAS 79-36-7 MFCD00000840-Dichloroacetyl chloride 二氯乙酰氯 TAO{mole}

Dichloroacetyl chloride 二氯乙酰氯

CAS 79-36-7 MFCD00000840

化学结构图

SMILES: O=C(Cl)C(Cl)Cl

化学属性

Mol. Formula	C2HCl3O
Mol. Weight	147
Density	1.532
Refractive index	1.4590 to 1.4620
Flash Point	None
TSCA	Yes
Boiling Point
Solubility	MAY DECOMPOSE
Melting Point	No Data Available

别名和识别编码

Chemical Name	Dichloroacetyl chloride
Synonym	2,2-DICHLOROACETYL CHLORIDE 2,2-dichloroacetyl 2,2-dichloroacetylchloride[qr] Acetyl chloride, dichloro- Acetylchloride,dichloro- Chlorure de dichloracetyle DICHLOROACETYL CHLORIDE DICHLOROETHANOYL CHLORIDE Dichloracetylchlorid Dichloroacethyl chloride Dichloroacetic acid chloride Dichloroacetyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number	79-36-7
EC Number	201-199-9
Beilstein Registry Number	2,204
MDL Number	MFCD00000840
Merck Number	3053
PubChem Substance ID	87567008
Reaxys-RN	1209426
Chemical Name Translation	二氯乙酰氯
Wiswesser Line Notation	GYGVG
LabNetwork Molecule ID	LN00226452
InChI	InChI=1S/C2HCl3O/c3-1(4)2(5)6/h1H

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产品应用

用于乙烯基杀虫剂的合成，还用于羊毛毡缩绒整理；漂白；脱色；保鲜；杀菌；消毒等。

安全信息

Signal word

GHS Symbol

WGK Germany2

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R35 Causes severe burns 会导致严重灼伤
R50 Very toxic to aquatic organisms 对水生生物极毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338+P310
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P301+P330+P331+P310
P303+P361+P353
P304+P340
P304+P340+P310
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P303+P361+P353+P310+P363
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P234 Keep only in original container. 只保留在原来的容器中。
P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。

RTECSAO6650000

Packing GroupII

UN Number UN1765 1765

Storage condition 4 Moisture Sensitive 密封保存

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes C,N

Hazard Class8

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 mg/kg/80W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,159,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 650 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19(Suppl 21),2,1992

Restrict 危险品

其他信息

MOL 文件:79-36-7.mol
毒性分级:中毒
用途一:用于有机合成及农药、医药中间体
Sigma Aldrich:79-36-7(sigmaaldrich)
用途三:用于乙烯基杀虫剂的合成，还用于羊毛毡缩绒整理、漂白、脱色、保鲜、杀菌、消毒等。
TCI Shanghai:二氯乙酰氯 Dichloroacetyl Chloride,>;98.0%(GC)(T)(79-36-7)
可燃性危险特性:遇明火、高热、氧化剂可燃; 受热或遇水、酸分解有毒氯化物气体
灭火剂:砂土、二氧化碳
用途二:用作有机合成中间体
Alfa Aesar:二氯乙酰氯,97% Dichloroacetyl chloride, 97%(79-36-7)
MSDS 信息:2,2-二氯乙酰氯(79-36-7).msds
能与乙醚混溶，遇水和醇会分解。在空气中会发烟。
Acros Organics:二氯乙酰氯 Dichloroacetyl chloride, 97%(79-36-7)
二氯乙酰氯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80045226 二氯乙酰氯（*） 100ml 160.3元 2011/04/16 D0313 二氯乙酰氯 Dichloroacetyl Chloride 500G 603元 2011/04/16 D0313 二氯乙酰氯 Dichloroacetyl Chloride 25G 160元
类别:腐蚀物品
刺激数据:皮肤- 兔子 10 毫克/ 24小时中度; 眼- 兔子 50 微克重度
急性毒性:口服- 大鼠 LD50: 2460 毫克/ 公斤
Hazard Note:Corrosive/Moisture Sensitive
用途四:用于乙烯基杀虫剂的合成，还用于羊毛毡缩绒整理；漂白；脱色；保鲜；杀菌；消毒等。
上游原料:三氯化铝 --> 氯磺酸 --> 氧 --> 偶氮二异丁腈 --> 三氯乙烯 --> 二氯乙酸
外观性质:发烟液体, 有刺激性气味。
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
下游产品:杀虫畏 --> 三氯乙酰氯 --> 庚烯磷 --> 氟咯草酮 --> 4-羟基-3-甲基苯乙酮
敏感性:Moisture Sensitive
F:19-21
图谱信息:二氯乙酰氯(79-36-7)质谱(MS) 二氯乙酰氯(79-36-7)核磁图( 13 CNMR) 二氯乙酰氯(79-36-7)红外图谱(IR1) 二氯乙酰氯(79-36-7)核磁图( 1 HNMR)
方法一:制备方法中可采用多种工艺路线。二氯乙酸与氯磺酸的反应，氯仿与一氧化碳在无水三氯化铝催化下反应，二氯乙酸与光气在二甲基甲酰胺中反应，以及用三氯乙烯氧化等都可制得该品。三氯乙烯与偶氮二异丁腈（催化剂）加热至100℃，通入氧气，在0.6MPa压力下反应，维持油浴温度在110℃，反应10h，于常压下蒸出产品二氯乙酰氯。本反应副产物三氯环氧乙烷与甲胺、三乙胺、吡啶等胺类化合物反应亦可转化为二氯乙酰氯。