2,2'-Dichlorodiethyl ether 二氯乙醚

CAS 111-44-4 MFCD00000975

化学结构图

111-44-4
SMILES: ClCCOCCCl

化学属性

Mol. FormulaC4H8Cl2O
Mol. Weight143
Refractive index1.4560 to 1.4590
Boiling Point65-67
Density1.22
Melting Point-47
Flash Point55°C
TSCAYes
Vapor Pressure0.4 mmHg ( 20 °C)
Solubility不溶于水,可混溶于乙醇、醚、多数有机溶剂。

别名和识别编码

Chemical Name2,2'-Dichlorodiethyl ether
Synonym 1,1'-OXYBIS(2-CHLORO)ETHANE 1-Chloro-2-(2-chloroethoxy)ethane 1-Chloro-2-(β-chloroethoxy)ethane 2,2'-Dichlor-diaethylaether 2,2'-Dichlorethylether 2,2-DICHLORODIETHYL ETHER 2,2ˊ 2,2ˊ-二氯二乙醚 2,2’-二氯二乙醚 2,4'-DICHLORODIETHYL ETHER 2-chlor 2-chloro-1-(2-chloroethoxy)-ethane sym-Dichloroethyl ether Bis(2-chloroet Bis(2-chloroethyl) ether,2-Chloroethyl ether DIETHYLENE GLYCOL DICHLORIDE Di(β-Chloroethyl) ether Dichloroethyl ether Khloreks Oxyde de chlorethyle SYM-DICHLORETHYL ETHER bis(2- bis(2-chloroethyl)ether bis(chloroethyl)ether {} {} {uni_hambu Β,Βˊ-二氯代二乙醚 Β-氯乙醚 β,β′-二氯代二乙醚
CAS Number111-44-4
PubChem Substance ID87563506
EC Number203-870-1
Beilstein Registry Number605317
MDL NumberMFCD00000975
Reaxys-RN605317
Merck Number3066
Chemical Name Translation二氯乙醚
Wiswesser Line NotationG2O2G
LabNetwork Molecule IDLN00225911
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分类

  • {SNA} Building Blocks, C2 to C7, Chemical Synthesis, Ethers, Organic Building Blocks, Oxygen Compounds
  • {uni_hamburg} no charge; ether; 1fragment
  • Building Blocks, C2 to C8, Chemical Synthesis, Ethers, Organic Building Blocks, Oxygen Compounds

相关文献及参考

  • Short: III/20a
  • Merck:14,3066 Beilstein:1(4)1375
  • Merck:14,3066
  • Short: III/38A

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H351 Suspected of causing cancer 怀疑致癌
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 6.1 T+ T+,T,F
RTECSKN0875000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P310+P361+P364
  • P303+P361+P353
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P311
  • P337+P313
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭,置于通风良好的场所;
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number 1916 UN1916
Packing GroupII
Hazard Class6.1/3
Storage condition 储存温度2-8℃ 2-8°C
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 33 gm/kg/79W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   42,1101,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   48,1431,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 209 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,163,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2A,2518,1981

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 330 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemica

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 30,63,1948

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1457 mg/plate
REFERENCE :
   DHEFDK HEW Publication (FDA. United States).  (Washington, DC)  ?-1979(?).
   For publisher information, see HPFSDS.  Volume(issue)/page/year:
   FDA-78-1046,1978

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10500 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,51,1994

Restrict 危险品

其他信息

  • 刺激数据:皮肤- 兔子 500 毫克 轻度; 眼睛- 兔子 100 毫克 重度
  • 外观性质:带有辣味和水果味的无色透明液体。
  • 灭火剂:干粉、泡沫
  • 检测方法:GC
  • 不溶于水,和大多数有机溶剂混溶。
  • 海关编码:29091900
  • Alfa Aesar:双(2-氯乙基)醚,99% Bis(2-chloroethyl) ether, 99%(111-44-4)
  • 爆炸物危险特性:与空气混合可爆
  • 方法一:二氯乙醚(111-44-4)由氯乙醇经分子间脱水而制得。也是乙烯与次氯酸制氯乙醇时的副产品。
  • Sigma Aldrich:111-44-4(sigmaaldrich)
  • Acros Organics:二(2-氯乙基)醚 2,2-Dichlorodiethylether, 99+%(111-44-4)
  • 二氯乙醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 B0472 双(2-氯乙基)醚 Bis(2-chloroethyl) Ether 25G 250元 2014/06/02 B0472 双(2-氯乙基)醚 Bis(2-chloroethyl) Ether 500G 484元 2010/06/21 264940050 二氯乙醚 2,2'-Dichlorodiethyl ether 99+% 5 ML 79元
  • MOL 文件:111-44-4.mol
  • 用途一:用作气相色谱固定液及脂肪、石蜡、油类等的溶剂和干洗剂
  • 可燃性危险特性:可燃; 燃烧产生有毒氯化物气体
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 类别:农药
  • 下游产品:N-甲基吗啡啉 --> 四氢吡喃-4-甲醛 --> 4-溴甲基四氢吡喃 --> 四氢吡喃-4-甲酸 --> 4-(2-氨乙基)四氢吡喃 --> 4-氨甲基四氢吡喃 --> 四氢吡喃-4-甲酰氯 --> (四氢-2H-吡喃-4-基)甲醇 --> 苄索氯铵 --> 2,2'-氧双(乙胺)盐酸盐 --> N-氨基吗啉 --> 地芬尼泰
  • 用途二:用作橡胶、树脂等的溶剂
  • 急性毒性:口服- 大鼠 LD50: 75 毫克/ 公斤; 口服- 小鼠 LD50: 209 毫克/ 公斤
  • TCI Shanghai:二(2-氯乙基)醚 Bis(2-chloroethyl) Ether,>;99.0%(GC)(111-44-4)
  • 职业标准:TWA 0.5 毫克/ 立方米; STEL 1.0 毫克/ 立方米
  • 毒性分级:高毒
  • 用途三:111-44-4(二氯乙醚)是合成N-甲基吗啉的原料药。同时也用作土壤熏蒸杀虫剂。
  • MSDS 信息:二氯乙醚(111-44-4).msds
  • 图谱信息:二氯乙醚(111-44-4)核磁图( 13 CNMR) 二氯乙醚(111-44-4)Raman光谱 二氯乙醚(111-44-4)质谱(MS) 二氯乙醚(111-44-4)核磁图( 1 HNMR) 二氯乙醚(111-44-4)红外图谱(IR1)
  • 蒸气压:0.4 mm Hg ( 20 °C)

系列性分类


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