Iodomethane 碘甲烷
CAS 74-88-4 MFCD00001073
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分类
- {SNA} Alkyl,
- {SA} Alkyl, Analytical Standards, Analytical/Chromatography, Building Blocks, Chemical Synthesis, Chromatography, Environmental Standards, Halogenated Hydrocarbons, Nematicides,
- {SNA} β-Glucuronidase Drug Analysis Bundle, Alkyl, Analytical and Industrial Enzymes, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, IOD - Iodomethane, Organic Building Blocks, 生化试剂, 酶、抑制剂和底物
- Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Environmental Standards,
相关文献及参考
- Merck 14 ,6087
- Beil. 1 ,IV,87
- Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI
- Short: II/14b Title: Molecular Constants: Radicals, Diatomic Molecules and Substance Index Author: Brown, J.M.; Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14b Page: 1-373 Year: 1983 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy; radicals ISBN: 3-540-11857-8 ISBN: 978-3-540-11857-2 Internet Resource: DOI:10.1007/b19967 RefComment: 196 figs., IX
- Short: II/19a Title: Molecular Constants: Rotational, l-type, Centrifugal Distortion and Related Constants of Diamagnetic Diatomic, Linear, and Symmetric Top Molecules Author: Demaison, J.; Hüttner, W.; Tiemann, E.; Wlodarczak, G. Editor: Hüttner, W. Source: Landolt-Börnstein, New Series Volume: II/19a Year: 1992 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-54409-7 ISBN: 978-3-540-54409-8 Internet Resource: DOI:10.1007/b42304 RefComment: XI, 143 pages. Abstract: Volume II/19 Molecular Constants mostly from Microwave, Molecular Beam and Sub-Doppler Laser Spectroscopy is a supplement to the earlier volumes II/4, II/6, and II/14. The slight change in the title reflects current trends in the applications of spectroscopic methods. Together, the four volumes collect all the critically evaluated data published up to 1989/90 on constants of free molecules obtained by classical and modern spectroscopy. Volume
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H315 Causes skin irritation 会刺激皮肤
- H331 Toxic if inhaled 吸入中毒
- H312 Harmful in contact with skin 皮肤接触有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H351 Suspected of causing cancer 怀疑致癌
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P301+P310+P330
- P304+P340+P310
- P308+P311
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R11 Highly flammable 非常易燃
- R21 Harmful in contact with skin 与皮肤接触有害
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S24 Avoid contact with skin 避免皮肤接触;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时,佩带适当的呼吸器;
- S4 Keep away from living quarters 远离生活区;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors Tumorigenic - tumors at site of application REFERENCE : ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 74,241,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg/8W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,1411,1975
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/m3/57M-C TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 7,122,1950
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 51 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,84,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 101 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 198
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 794 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Blood - hemorrhage REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 20 umol/L REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 46,277,1980
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 2 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,137,1984
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 50 mg/L/4H REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 59,61,1979
TYPE OF
TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 10 ug/disc REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,873,1979
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 3600 ug/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 1000 ppm REFERENCE : JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,901,1979
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其他信息
- 实验室制备碘甲烷:在甲醇与红磷的混合物中加入碘时,会发生放热反应而生成碘甲烷:5 CH3OH + P + 2.5 I2 → 5 CH3I + H3PO4 + H2O 反应中生成了三碘化磷中间体,起到了与甲醇发生碘化反应的作用。 碘甲烷也可由硫酸二甲酯与碘化钾在碳酸钙存在下反应制得:(CH3O)2SO2 + KI → K2SO4 + 2 CH3I 先将反应产物蒸馏,然后用Na2S2O3、水和Na2CO3溶液洗涤,便可得到纯净的碘甲烷。
- 外观性质:无色液体,有特臭。
- MSDS 信息:碘甲烷(74-88-4).msds
- {Chemicalbook
- 用途二:用作分析试剂,也用于制药工业
- 毒性分级:高毒
- 下游产品:6-甲基-3-甲氧基-2-碘吡啶 --> 哌唑嗪 --> 4-甲基-2-甲硫基嘧啶 --> 2-甲基-5-甲氧基吡啶 --> 2,2-二甲基环戊酮 --> 克拉霉素 --> 2-甲硫基-4-氯-5-溴嘧啶 --> 2-甲基-2H-吲唑-3-甲酸 --> 2-甲硫基-4-苯甲氨基嘧啶 --> (S)-(-)-环氧丙基甲基醚 --> 2-甲硫基-4-氯嘧啶 --> 2-溴-3-甲氧基-6-甲基吡啶 --> 轻水泡沫灭火剂 FC-4 --> 4-氯-N-甲基嘧啶-2-胺 --> (1-甲基-1H-苯并眯唑-2-基)甲胺 --> 2,2-二甲基环己酮 --> 阿司咪唑 --> 3-甲基-4-硝基苯甲醚 --> (R)-(-)-环氧丙基甲基醚 --> 2-甲硫基-4,6-二甲基嘧啶 --> 7-甲氧基香豆素 --> 新戊基碘 --> 轻水泡沫灭火剂 FC-3 --> 1-(2-二甲基氨基乙基)-1H-5-巯基-四氮唑 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸 --> 坎利酮 --> 2-苯基-2-丙醇 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸-Γ-内酯 --> 美雄醇 --> 5-巯基-1,2,3,4-四氮唑-1-甲基磺酸 --> 2-乙酰基-3-甲基吡嗪 --> 3Β,17Β-二羟基雄甾-5-烯-17Α-丙炔酸 --> 碘化1,2-二甲基吡啶鎓 --> 雄甾-5-烯-3,17-二醇-17-丙炔酸钾盐 --> 苄基三甲基碘化铵
- 图谱信息:碘甲烷(
- Acros Organics:碘甲烷 Iodomethane,stabilized,99%(74-88-4)
- F:8
- 甲基化反应:碘甲烷与碳酸二甲酯、硫酸二甲酯、三氟甲磺酸甲酯是常见的甲基化试剂 根据软硬酸碱理论,碘是“软”的阴离子,因而碘甲烷所参与的甲基化反应也应在两位亲核试剂较“软”的一段发生。比如,在与硫氰酸根离子反应时,S更软,因而从S原子进攻的可能性较从N原子进攻的可能性大,产物主要是硫氰酸甲酯(CH3SCN)而非CH3NCS。而且,碘甲烷与1,3-二羰基化合物生成的烯醇盐之间发生的反应也可用以上理论来解释。相对于碳原子,氧原子较硬,碘甲烷参与的反应也几乎都生成C-甲基化的产物。 碘甲烷甲基化具有以下一些缺点: 它相对分子质量较大,一摩尔MeI的质量几乎等于三摩尔CH3Cl的质量; 碘化合物较氯化物和溴化物仍显得比较昂贵,因而在工业上更加便宜的硫酸二甲酯仍有不少应用,尽管它的毒性比碘甲烷要高出很多; 碘离子离去基团可能会造成副反应; 碘甲烷的毒性比相应的氯化合物和溴化合物要大,对生产工人很不利。 因此在选择甲基化试剂时,通常要均衡考虑价格、来源、毒性、化学选择性及反应容易程度等诸多因素。
- 用途一:主要用作甲基化试剂,在医药工业中用于碘甲基蛋氨酸(维生素U)、镇痛药、解毒药磷酸系药物的生产
- 概述:碘甲烷是一个卤代烃,分子式为CH3I、MeI,是甲烷的一碘取代物。沸点42.4℃,相对密度2.279(20/4℃),室温下为密度大的挥发性液体,偶极矩1.59D,折射率1.5304(20°C、D)、1.5293(21°C、D)。碘甲烷可与常见的有机溶剂混溶,微溶于水,溶于乙醇、乙醚,纯品无色,特臭,暴露于阳光下会分解出I2而带紫色,可通过加入金属铜
- 急性毒性:吸入-大鼠LC50: 1300毫克/立方米/4小时; 腹腔-小鼠LD50:172 毫克/ 公斤
- 用途三:医药工业用于碘甲基蛋氨酸(维生素U)、镇痛