CAS 108-94-1 MFCD00001625-Cyclohexanone 环己酮 TAO{mole}

Cyclohexanone 环己酮

CAS 108-94-1 MFCD00001625

化学结构图

SMILES: O=C1CCCCC1

化学属性

Mol. Formula	C6H10O
Mol. Weight	98
Density	0.947
Autoignition Point	788 °F
Refractive index	1.4490 to 1.4530
Vapor Density	3.4 (vs air)
Boiling Point	157°C
Vapor Pressure	3.4 mmHg ( 20 °C)
Melting Point	-47
Flash Point	44°C(lit.)
TSCA	Yes
Solubility	微溶于水，可混溶于醇、醚、苯、丙酮等多数有机溶剂。
Danger-Level	乙类

别名和识别编码

Chemical Name	Cyclohexanone
CAS Number	108-94-1
EC Number	203-631-1
Beilstein Registry Number	7,8
MDL Number	MFCD00001625
Synonym	AKOS BBS-00004296 ANONE Anon Anone C₆H₁₀O (cyclohexanone) CYCLOHEXANONE Cicloesanone Cyclohexanon Cyclohexanone Cyclohexyl ketone Cykloheksanon FEMA 3909 HEXANONE Hexanon Hytrol O KETOCYCLOHEXANE KETOHEXAMETHYLENE Ketohexamethylene NCI-C55005 Nadone Oxocyclohexane PIMELIC KETONE Pimelic ketone Pimelin ketone RCRA waste number U057 Sextone caswellno270 cyclohexanone cykloheksanon(polish) epapesticidechemicalcode025902 hytrolo {} {} {} {} {} {} {} {} {} {uni_hamburg} 安酮环己酮
PubChem Substance ID	7967
Merck Number	2726
Reaxys-RN	385735
Chemical Name Translation	环己酮
Wiswesser Line Notation	L6VTJ
LabNetwork Molecule ID	LN00195875
InChI	InChI=1S/C6H10O/c7-6-4-2-1-3-5-6/h1-5H2

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分类

{SNA} Analytical Reagents for General Use,
{SNA} A-F, Additional Standards, Alcoholic & Nonalcoholic Beverages, Alpha Sort, Analytical Standards, C, Chromatography, Environmental Standards, Food & Beverage Standards, Food and Cosmetic Component Standards, Organic Pollutant Standards, Tea, Volatiles & Semivolatiles, Volatiles/ Semivolatiles, other, 分析/色谱, 化合物分类, 按字母排序, 食品饮料类产品, 香精香料
{SNA} A-C,
{SNA} Analytical/Chromatography, Ion Sensor Materials,
{SNA} Ocimum basilicum (Basil), Phytochemicals by Plant (Food/Spice/Herb),
{SNA} Alphabetical Listings, C-D,

产品应用

纤维、树脂、橡胶、石蜡、虫胶和DDT的溶剂，有机合成，能溶解许多由元素与有机试剂所形成的络合物，测定铋，萃取稀有金属铀、钍、钴和钛的试剂。

安全信息

Signal word

GHS Symbol

WGK Germany1

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R10 Flammable 易燃
R20 Harmful by inhalation 吸入有害

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P241+P242+P243
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P310+P331+P330
P301+P312
P301+P316
P301+P317
P302
P302+P352
P302+P352+P312+P361+P364
P303+P361+P353
P304+P312
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P305+P354+P338
P307+P311
P308+P311
P308+P313
P308+P316
P309+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P317
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P331 Do NOT induce vomiting.. 不要催吐。
P332+P313
P332+P317
P333+P313
P333+P317
P337+P313

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H302 Harmful if swallowed 吞食有害
H302+H312+H332
H312 Harmful in contact with skin 皮肤接触有害
H315 Causes skin irritation 会刺激皮肤
H318 Causes serious eye damage 严重伤害眼睛
H332 Harmful if inhaled 吸入有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSGW1050000

Packing GroupIII

UN Number 1915

Hazard Codes

Storage condition 密封保存 Flammables area

Hazard Class3

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1130 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   49,525,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   30,470,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 25,415,1943

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - specie

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 uL/L
REFERENCE :
   EJMBA2 Egyptian Journal of Microbiology.  (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.7-
   1972-  Volume(issue)/page/year: 18,213,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 7500 uL/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   3),60,1985

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   DBTEAD Diabete.  (Le Raincy, France)  V.1-22, 1953-74.  Discontinued.
   Volume(issue)/page/year: 19,215,1971

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 ug/L
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 46(5),76,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 7500 uL/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl
   3),60,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 200 uL/L
REFERENCE :
   EJMBA2 Egyptian Journal of Microbiology.  (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.7-
   1972-  Volume(issue)/pag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 11 gm/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   6,361,1986

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 mg/m3/4H
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,26,1975

Restrict 危险品

其他信息

{C
毒性分级:中毒
下游产品:盐酸曲马多 --> 恩丹西酮 --> 盐酸文拉法辛 --> (1S,2S)-1,2-二苯基乙二胺 --> 地夫可特 --> 乙炔环己醇 --> 文拉法辛 --> 9-胺-1,2,3,4-四氢盐酸氯酯 --> 2-环己酮甲酸乙酯 --> 丁硫克百威 --> 烯草酮 --> 2-乙基环己酮 --> 普拉克索 --> 2-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩 --> N-甲基环己胺 --> 酸性橙33 --> 沃氏物 --> 磺胺二甲嘧啶 --> 2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯 --> 环庚酮 --> 1,2-环己二酮 --> 2-(1-环己烯基)环己酮 --> 6-己内酯 --> 过氧化环己酮 --> 1-硝甲基环己醇 --> 过氧化环己酮 --> 聚氨酯清漆 --> 1号吸塑包装胶粘剂 --> 1-羟基环己烷乙腈 --> N,N-二甲基环己胺 --> 氨甲环己醇盐酸盐 --> 1-(1-环己烯基)哌啶 --> 仿瓷涂料 --> 2-氯环己酮
Acros Organics:环已酮 Cyclohexanone, extra pure, 99.8%(108-94-1)
急性毒性:口服- 大鼠 LD50: 1535 毫克/ 公斤; 口服- 小鼠 LD50: 1400 毫克/ 公斤
职业标准:TWA 100 毫克/立方米; STEL 125 毫克/立方米
储运特性:库房通风低温干燥; 与氧化剂分开存放
常规方法:采用铁桶包装，也可用槽车运输。贮运中严禁烟火和撞击。
方法一:40年代，环己酮的工业生产采用以苯酚为原料加氢生成环己醇，再脱氢得环己酮。60年代，随着石油化工的发展，环己烷氧化生产环己酮的方法在工业上逐步占主导地位。1967年，
爆炸物危险特性:与空气混合可爆
Alfa Aesar:环己酮,ACS,99+% Cyclohexanone, ACS, 99+%(108-94-1)
灭火剂
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许
环己酮价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10008490 环己酮 500ml 140元 2011/08/23 10008418 环己酮 500ml 17元 2011/08/23 100084193 环己酮 20kg 24元
上游原料:氢氧化钠 --> 苯 --> 过氧化氢 --> 氢 --> Α-球蛋白 --> 环己烷 --> 石脑油，原油 --> 环己醇 --> 重苯 --> 2-己酮 --> 铬酸叔丁酯 --> 1108 --> 环己酮醇
用途二:用作有机溶剂
TCI Shanghai:环己酮 Cy
类别:易燃液体
MOL 文件:108-94-1.mol
用途一:用作合成树脂和合成纤维的原料及溶剂
用途三:是生产己内酰胺和己二酸的原料，用作油漆、油墨、合成树脂、合成橡胶的溶剂和稀释剂，还用作皮革脱脂剂等
防护措施:高浓度的环己酮蒸气有麻醉性，对中枢神经系统有抑制作用。对皮肤和粘膜有刺激作用。高浓度的环己酮发生中毒时会损害血管，引起心肌，肺，肝，脾，肾及脑病变，发生大块凝固性坏死。通过皮肤吸收引起震颤麻醉、降低体温、终至死亡。在25ppm的气氛下刺激性小，但在50ppm以上时，就无法忍受。对小鼠的LC为0.008。工作场所环己酮的最高容许浓度为200mg/m3。生产设备应密闭，应防止跑、冒、滴、漏。操作人员穿戴好防护用具。
蒸气压:3.4 mm Hg (
可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产
有丙酮及薄荷气味，能溶于水、醇、醚及一般有机溶剂，在冷水中溶解度大于热水。
Sigma Aldrich:108-94-1(sigmaaldrich)