• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Chemical Synthesis, Organometallic Reagents, Organotin, Organotin Oxides

相关文献及参考

• Reacts with 1,2-diols to form 5-membered cyclic dibutylstannoxane derivatives. For use in the glycoside field, see: Synthesis, 409 (1995). Formation of these derivatives is greatly accelerated by microwave irradiation: Synlett, 89 (1994). The stannylene derivatives are activated to electrophilic attack:
• With bromine, the ɑ-hydroxy ketone is formed: J. Chem. Soc., Perkin 1, 1568 (1979). With acyl or sulfonyl chlorides, overall regioselective monoacylation of the diol at the more substituted hydroxyl can be achieved: Tetrahedron Lett., 21, 221 (1980); J. Chem. Soc., Chem. Commun., 1457 (1985); J. Org. Chem., 55, 5132 (1990); 61, 5257 (1996). Selective monotosylation of 1,2-diols has also been achieved catalytically: Tetrahedron Lett., 41, 3773 (2000).
• Catalyst for lactonization and lactamization reactions: J. Am. Chem. Soc., 102, 7578 (1980), particularly useful in the formation of macrolides: J. Am. Chem. Soc., 105, 7130 (1983). For catalysis of N-acylation of hydroxy alcohols with microwave irradiation, see: J. Org. Chem., 61, 5264 (1996).
• Promotes the cycloaddition of Trimethyl­silyl­ azide, L00173 to nitriles to give 5-aryltetrazoles, some of which are important as angiotensin II inhibitors: J. Org. Chem., 58, 4139 (1993):
• Catalyst for the dehydration of amides to nitriles under neutral conditions: Synthesis, 1724 (1999); for use of microwave irradiation, see: J. Org. Chem., 64, 1713 (1999).
• For a brief feature on uses of the reagent in synthesis, see: Synlett, 1847 (2004).

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - general anesthetic
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 7,47,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 15,3,1973

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Kidney, Ureter, Bladder - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0570737

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44900 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie;

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 19916 ug/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 85,149,1993

其他信息

• 海关编码:29310095
• Acros Organics:二丁基氧化锡 Dibutyltinoxide,98%(818-08-6)
• 灭火剂:水, 砂土, 泡沫, 二氧化碳
• 方法一:工业制法主要有以下两种：1.格氏法 以氯代丁烷或溴代丁烷为原料，通过格利雅反应制成四丁基锡，后者再与四氯化锡反应成二氯二丁基锡。二氯二丁基锡用烧碱处理即得二丁基氧化锡。格氏法步骤较繁杂，但副反应少，产品纯度高。2.直接法 包括碘代烷法、溴代烷法和氯代烷法其中碘代烷法最常用，直接法过程简单，但副反应较多，产品质量差，且消耗比较昂贵的碘。
• 外观性质:白色至微黄色粉末。
• 刺激数据:皮肤-兔子 500 毫克/24小时 轻度; 眼睛-兔子 100 毫克/24小时 中度
• 类别:有毒物品
• 毒性分级:剧毒
• 二丁基氧化锡价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K3498001 二丁基氧化锡(剧毒) 100g 333元 2010/06/21 179361000 二丁基氧化锡 Dibutyltin oxide 98% 100 GR 289元 2010/06/21 179365000 二丁基氧化锡 Dibutyltin oxide 98% 500 GR 1016元
• 职业标准:TLV-TWA 0.1 毫克 (锡)/立方米; STEL 0.2 毫克 (锡)/立方米
• 用途二:用作制备二丁基锡类稳定剂的中间体，用于生产月桂酸二丁基锡、马来酸二丁基锡、马来酸单丁酯二丁基锡。
• TSCA:Yes
• 上游原料:氢氧化钠 --> 锡 --> 溴丁烷 --> 1-氯丁烷 --> 氯代烷 --> 四丁基锡 --> 二丁基二氯化锡
• 储运特性:库房通风低温干燥; 与氧化剂, 食品分开储运
• MSDS 信息:氧化二丁基锡(818-08-6).msds
• 下游产品:二月桂酸二丁基锡 --> 二丁基马来酸锡
• 用途一:是合成有机锡的中间体之一，应用于PVC热稳定剂、SPC自抛光海洋防污涂料等
• 急性毒性:口服-大鼠 LD50: 44.9 毫克/公斤
• Alfa Aesar:二正丁基氧化锡,98% Di-n-butyltin oxide, 98%(818-08-6)
• Sigma Aldrich:818-08-6(sigmaaldrich)
• 可燃性危险特性:遇火可自燃; 火场产生有毒锡氧化物烟雾
• 图谱信息:二丁基氧化锡(818-08-6)红外图谱(IR2) 二丁基氧化锡(818-08-6)红外图谱(IR1)
• MOL 文件:818-08-6.mol