Bromopyruvic acid 3-溴丙酮酸
CAS 1113-59-3 MFCD00002587
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks, 己糖激酶抑制剂, 有氧糖酵解(Warburg效应), 有氧糖酵解(Warburg效应)抑制剂, 癌症代谢, 癌症研究, 细胞生物学
- {SNA} Aerobic Glycolysis (the Warburg
产品应用
- 半胱氨酸残基的亲和标记;核酸和蛋白质之间的交联剂
相关文献及参考
- [2]. Chen Y, et al. 3 Bromopyruvate sensitizes human breast cancer cells to TRAIL induced apoptosis via the phosphorylated AMPK mediated upregulation of DR5. Oncol Rep. 2018;40(5):2435-2444.
- [3]. Zhang Q, et al. Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells. Genes Cancer. 2014;5(3-4):100-112.
- Ko Y.H. et al.: Cancer Lett., 173, 83 (2001); Geschwind J.F. et al.: Cancer Res., 62, 3209 (2002); Ko Y.H. et al.: J. Bioenerg. Biomembr., 44, 163 (2012);
- [1]. Gan L, et al. Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy. Onco Targets Ther. 2020;13:11125-11137. Published 2020 Oct 29.
- [1]. Gan L, et al. Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy. Onco Targets Ther. 2020;13:11125-11137. Published 2020 Oct 29.
- [2]. Chen Y, et al.
安全信息
GHS Symbol
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R34 Causes burns 会导致灼伤
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,48,1958
其他信息
- 下游产品:溴代丙酮酸甲酯
- 类别:有毒物质
- 图谱信息:3-溴丙酮酸(1113-59-3)质谱(MS) 3-溴丙酮酸(1113-59-3)红外图谱(IR2) 3-溴丙酮酸(1113-59-3)红外图谱(IR1) 3-溴丙酮酸(1113-59-3)核磁图( 1 HNMR)
- 毒性分级:高毒
- MOL 文件:1113-59-3.mol
- 用途一:3-溴代丙酮酸是杀菌剂噻菌灵的中间体。
- Sigma Aldrich:1113-59-3(sigmaaldrich)
- 可燃性危险特性:热分解排出有毒溴化物蒸汽
- 急性毒性:腹腔-小鼠 LD50: 72 毫克/公斤
- MSDS 信息:Bromopyruvic acid(1113-59-3).msds
- 方法一:其制备方法是将丙酮酸中加入少许浓硫酸和溶剂二氯甲烷置于反应瓶中,滴加溴约需3.5h,并搅拌,有白色沉淀产生,再继续搅拌1h,用环己烷和石油醚稀释,然后冷却反应混合物得到结晶,过滤,用石油醚洗涤并干燥得到产品。
- Alfa Aesar:溴丙酮酸,97% Bromopyruvic acid, 97%(1113-59-3)
- Hazard Note:Corrosive
- F:19-21
- 上游原料:硫酸 --> 二氯甲烷 --> 石油醚 --> 甲苯 --> 溴 --> 环己烷 --> 浓硫酸 --> 丙酮酸 --> 环己烯
- 检测方法:T
- 储运特性:库房通风低温干燥; 与食品原料分开存放
- TCI Shanghai:3-溴丙酮酸 3-Bromopyruvic Acid,>;98.0%(T)(1113-59-3)
- 3-溴丙酮酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L0072002 Alfa-L00720 10g 759元 2011/04/16 B1153 3-溴丙酮酸 3-Bromopyruvic Acid 5G 530元 2011/04/16 B1153 3-溴丙酮酸 3-Bromopyruvic Acid 25G 1630元
- 灭火剂:泡沫、干粉、二氧化碳、雾状水