CAS 22839-47-0 MFCD00002724-Aspartame 天冬氨酰苯丙氨酸甲酯 TAO{mole}

Aspartame 天冬氨酰苯丙氨酸甲酯

CAS 22839-47-0 MFCD00002724

化学结构图

SMILES: COC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@@H](N)CC(O)=O

化学属性

Mol. Formula	HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
Mol. Weight	294
Melting Point	248-250
Density	1.28

别名和识别编码

Chemical Name	Aspartame
CAS Number	22839-47-0
Synonym	3-Amino-N-(alpha-carboxyphenethyl)succinamic acid N-methyl ester, ?-Aspartame ?-L-Aspartyl- Canderel Dipeptide Sweetener E 951 Equal L-?-Aspartyl-L-phenylalanine 2-Methyl Ester L-Aspartame L-Aspartyl-L-phenylalanine methyl ester; Equal; Nutrasweet N-(L-α-天冬氨酰)-L-苯丙氨酸甲酯天冬甜素阿斯巴甜 N-(L-α-天冬氨酰)-L-苯丙氨酸甲酯 N-L--Aspartyl-L-phenylalanine 1-Methyl Ester N-L-α-Aspartyl-L-phenylalanine 1-Methyl Ester NutraSweet Palsweet Diet Zero-Cal 天冬甜素天冬酰-苯丙氨酸甲酯蛋白糖,甜乐,甜味素,N-L-α-天冬氨酰-L-苯丙氨酸甲酯,天冬氨酰苯丙氨酸甲酯阿斯巴甜
Beilstein Registry Number	2223850
PubChem Substance ID	87562491
EC Number	245-261-3
MDL Number	MFCD00002724
Reaxys-RN	2223850
Merck Number	839
Chemical Name Translation	天冬氨酰苯丙氨酸甲酯

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

A dipeptide ester about 160 times sweeter than sucrose in aqueous solution. A non-nutritive sweetener.

安全信息

RTECSWM3407000

WGK Germany2

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Signal word Warning

GHS Symbol

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

Storage condition 2-8℃

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (3),37,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (3),37,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (3),37,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 3710 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   104,207,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4 gm/kg
SEX/DURATION            : female 15-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   RCPBDC Research Communications in Psychology, Psychiatry and Behavior. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1976-
   Volume(issue)/page/year: 9,385,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 449 gm/kg
SEX/DURATION            : male 2 week(s) pre-mating
                          female 2 week(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   NETOD7 Neurobehavioral Toxicology.  (Fayetteville, NY)  V.1-2, 1979-80. For
   publisher information, see NTOTDY.  Volume(issue)/page/year: 1,79,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE                    : 32500 mg/kg
SEX/DURATION            : female 1-65 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   11,413,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 275 gm/kg
SEX/DURATION            : male 2 week(s) pre-mating
                          female 2 week(s) pre-mating  - 16 d

TYPE OF TEST            : TDLo - Lowest p

其他信息

微溶于水（约1%）和乙醇（0.26mg/100ml）。无臭、有强烈甜味，其稀溶液的甜度约为蔗糖的100-200倍。其甜味与砂糖十分相似，并有清凉感。0.8%水溶液的pH值为4-6.5。在水溶液中不稳定，易分解而失去甜味，低温时和pH值3-5时较稳定。