CAS 1596-84-5 MFCD00002787-Daminozide 丁酰肼 TAO{mole}

Daminozide 丁酰肼

CAS 1596-84-5 MFCD00002787

化学结构图

SMILES: CN(C)NC(=O)CCC(=O)O

化学属性

Mol. Formula	C6H12N2O3
Mol. Weight	160.17
Density	1.183
Melting Point	162-164 °C
Solubility	溶于水，不溶于烃类。

别名和识别编码

Chemical Name	Daminozide
Synonym	Daminozide {LY} Daminozide Kylar Mono(2,2-dime N-(Dimethylamino)succinamic acid N-(dimethylamino)succinamic acid N-Dimethylamino-succinamidsaeure N-dimethylaminosuccinamic acid N-二甲基琥珀酰肼 SADH(R) SUCCINIC ACID 2,2-DIMETHYLHYDRAZINE Succinic acid 2,2-dimethylhydrazide alar-85 butanedioic acid, mono(2,2-dimethylhydrazide) daminozide daminozide (ISO) succinic N',N' succinic acid, 2,2-dimethyl hydrazide {} {LY} Daminozide {} {} {LY} Daminozide {} {} {} {LY} Daminozide {} {} {} {} { {} {} {} {} {LY} Daminozide {} {} {} {} {} {LY} Daminozide {} {} {} {} {} {} {LY} Daminozide {} {} {} {} {} {} {} {LY} Daminozide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Daminozide {} {} {} {} {} {} {} {} {} {LY} Daminozi
CAS Number	1596-84-5
EC Number	216-485-9
Beilstein Registry Number	1863230
MDL Number	MFCD00002787
PubChem Substance ID	15331
Reaxys-RN	1863230
Merck Number	2810
Chemical Name Translation	丁酰肼
Wiswesser Line Notation	QV2VMN1&1
InChI	InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
Canonical SMILES	O=C(NN(C)C)CCC(O)=O

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分类

{SA} Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, D, DA - DH, Environmental Standards,
{SNA} All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, D, DA - DH, Environmental Standards, Pesticides, Pesticides & Metabolites, Pesticides, Bactericides, Fungicides and Disinfectants, Plant growth regulators, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009)
{uni_hamburg} no charge; carboxylic acid; amide; 1fragment
{SNA} Analytical Standards,
{SNA} Analytical Standards,

产品应用

比久是一种生长抑制剂。它可抑制内源赤霉素的生物合成，也可抑制内源生长素的合成.

安全信息

Signal word Warning

GHS Symbol

WGK Germany2

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Precautionary statements

P203
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P305+P351+P338
P305+P351+P338+P337+P313
P318
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSWM9625000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes Xn

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H351 Suspected of causing cancer 怀疑致癌

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 182 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-83,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 873 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-83,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2600 gm/kg/62W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,3497,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,224,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMCHA2 Farm Chemicals Handbook.  (Meister Pub., 37841 Euclid Ave.,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 8400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 1971  Volume(issue)/page/year: -,127,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : In

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   32BBAV "Materialy Nauchnoi Konferentsii Kaunasskogo Meditsinskogo Inst.,
   22nd, 1972," Materials of the Scientific Conference of Kaunas Medical
   Institute, Vaichyuvenas, V.A., ed., Kaunas, USSR, Kaunasskii Meditsinskii
   Institut, 1973  Volume(issue)/page/year: 22,126,1973

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1650 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 156 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

其他信息

灭火剂:干粉
分析方法:1. 产品分析：采取容量法用甲酚红作指示剂，以0.1N氢氧化钠溶液滴定。
储运特性:库房通风低温干燥; 与食品原料分开储运
不溶于一般的碳氢化合物。贮存稳定性好。
使用方
可燃性危险特性:燃烧产生有毒氮氧化物气体
方法一:以丁二酸为原料，先脱水制得丁二酸酐，再与偏二甲肼在乙腈中缩合而得。操作步骤是：将丁二酸一次投入反应釜，升温至215℃左右，开始脱水，直至釜温升至260℃左右，出水量达到理论量。在缩合釜中投入乙腈，再中入丁二酸酐，当料温控制在18℃时，慢慢滴加偏二甲肼，反应结束后，离心过滤、干燥得比久。
用途四:比久是一种生长抑制剂。它可抑制内源赤霉素的生物合成，也可抑制内源生长素的合成.
用途三:丁酰肼能抑制植物生长，促进矮壮，而不影响开花结果。对作物有增加耐寒、耐旱能力、防止落花落果及促进结实增产等效果。
用途二:植物生长抑制剂。促进矮化，并能调整树干高度和观赏植物外形，而不影响开花影响。对作物有增加耐寒、耐旱能力，促进结实增产等效果。其作用机制是抑制内源生长素的合成。可用于果树、马铃薯、甘薯、番茄、草莓、菊花、人参等。国家农业部已撤销在花生上的登记。
毒性分级:低毒
毒性:原药对大鼠急性经口LD 50 8400mg/kg，兔急性经皮LD 50 >1600mg/kg。85%制剂对无尾鹌鹑经口LD 50 >5620mg/kg。对虹鳟鱼LC 50 360mg/L（96h)，翻车鱼650mg/L(96h)。
使用方法:丁酰肼又称比久，属于低毒性植物生长调节剂，可以作矮化剂、坐果剂、生根剂及保鲜剂等。苹果在盛花后三周用1000～2000毫克/升药液喷洒全株一
植物生长调节剂:丁酰肼是一种植物生长调节剂的抑制剂，1962年由美国橡胶公司研发成功，其作用是阻止细胞分裂，抑制细胞伸长，矮化幼苗，并可提高花生的抗旱性，使许多果树提前开花，提高坐果率和防止采前落果等。丁酰肼被植物吸收后，可以抑制植物体内的内源赤霉素的生物合成和内源生长素的合成，主要作用是抑制新枝徒长，缩短节间长度，增加叶片厚度及叶绿素含量，防治落花促进坐果，诱导不定根形成，刺激根系生长，提高抗寒力。丁酰肼通过植物根、茎、叶进入体内，具有良好的内吸、传导性能，随营养流传导到作用部位，在叶片中，丁酰肼可使叶片栅栏组织伸长，海绵组织疏松，提高叶绿素含量，增强叶片的光合作用。在植株顶部可抑制顶端分生组织的有丝分裂。在茎枝内可缩短节间距离，抑制枝条的伸长。丁酰肼是具广谱性、适用性的植物生长调节剂。 20世纪80年代中后期怀疑其具有致畸作用，有些国家曾禁用或限制使用。1992年世界卫生组织进行再次评估，认为产品中丁酰肼的水解产物偏二甲基肼(或称非对称二甲基联氨)含量小于30毫克／千克可以使用。但仍须注意，近期将收获的作物勿使用，也不要食用刚用药处理不久的果品等农产品，最好不要用在蔬菜上。以上信息由ChemicalBook的彤彤编辑。
MOL 文件:1596-84-5.mol
使用方法:丁酰肼又称比久，属于低毒性植物生长调节剂，可以作矮化剂、坐果剂、生根剂及保鲜剂等。苹果在盛花后三周用1000～2000毫克/升药液喷洒全株一次，可抑制新梢旺长，有益于坐果，促进果实着色; 在采前45～60天以2000～4000毫克/升药液喷洒全株一次，可防采前落果，延长贮存期。葡萄在新梢6～7片叶时以1000～2000毫克/升药液喷洒一次，可抑制新梢旺长，促进坐果;采收后以1000～2000毫克/升药液浸泡3～5分钟，可防止落粒延长贮存期。桃在成熟前以1000～2000毫克/升药液喷洒一次，增加着色、促进早熟。梨盛花后两周和采前三周各用1000～2000毫克/升药液喷洒一次，可防止幼果及采前落果。土豆盛花后两周以3000毫克/升药液喷洒一次，可抑制地上部徒长，促进块茎膨大。樱桃盛花后两周以2000～4000毫
注意事项:[1]制剂使用时随配随用，如变褐色就不能使用。 [2]可与多种农药混用但不能与碱性物质、油及铜制剂混用
上游原料:丁二酸酐 --> 丁二酸 --> 1,1-二甲基肼