CAS 67-20-9 MFCD00003224-Nitrofurantoin 呋喃妥英 TAO{mole}

Nitrofurantoin 呋喃妥英

CAS 67-20-9 MFCD00003224

化学结构图

SMILES: O=C1CN(/N=C/c2ccc([N+](=O)[O-])o2)C(=O)N1

化学属性

Mol. Formula	C8H6N4O5
Mol. Weight	238.16 g/mol
Melting Point	268°C
TSCA	Yes
Solubility	<0.01 G/100 ML AT 19 ºC
Density	0.915
Stability	对光敏感
Appearance	crystalline 橙黄色针状结晶。熔点270-272℃（分解）。在100ml下列溶剂中可溶解的毫克数：水19.0，95%乙醇51.0，丙酮510，DMF8000。几乎不溶于氯仿。遇光颜色变深，无臭，味苦。

别名和识别编码

Chemical Name	Nitrofurantoin
MDL Number	MFCD00003224
CAS Number	67-20-9
Synonym	1-(((5-nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione 1-(((5-nitro-2-furanyl)methylene)amino)-4-imidazolidinedione 1-((5-nitrofurfurylidene)amino)-hydantoi 1-[(5-Nitrofurfurylidene)amino]hydantoin; 1-(((5-Nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione 1-[(5-硝基-2-呋 1-[[(5-硝基-2-呋喃基)亚甲基]氨基]-2,4-咪唑烷二酮 2,4-Imidazolidinedione, 1-(((5-nitro-2-furanyl)methylene)amino)- Dantafur N-(5-NITRO-2-FURFURYLIDENE)-1-AMINOHYDANTOIN N-(5-硝基-2-呋喃亚甲基)-1-氨基海因呋喃坦啶硝基呋喃妥因 NCI-C55196 Nitrofurantoin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID	125307704
Beilstein Registry Number	22(5)5,224
EC Number	200-646-5
Reaxys-RN	290482
Merck Number	6599
Chemical Name Translation	呋喃妥英
Wiswesser Line Notation	T5OJ BNW E1UN- AT5NVMV EHJ
Canonical SMILES	O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O

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品牌质保精细包装现货库存一流品牌服务

产品应用

本品为合成抗菌药，抗菌谱较广，对大多数革兰阳性菌及阴性菌均有抗菌作用，如金葡菌、大肠杆菌、白色葡萄球菌及化脓性链球菌等。临床上用于敏感菌所致的泌尿系统感染，如肾盂肾炎、尿路感染、膀胱炎及前列腺炎等。
校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

RTECSMU2800000

GHS Symbol

Precautionary statements

P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P352+P333+P313+P362+P364
P308+P313
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P201 Obtain special instructions before use. 使用前获取专门指示。
P405 Store locked up. 上锁保管。
P304+P341
P301+P312+P330

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

WGK Germany1

Signal word

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R42/43

Storage condition 0-6°C 2-8°C Light Sensitive & Hygroscopic 棕色螺口小玻璃瓶包装，冷藏、避光、干燥条件下保存。

Hazard Codes Xn

Packing GroupIII

Hazard Class6.1(b)

UN Number 2811

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 21630 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-341,1989

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   21,303,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10815 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-341,1989

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   102,505,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 42 mg/kg/6W-I
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), diffuse
   Liver - jaundice, other or unclassified
   Liver - liver function tests impaired
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 156

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 29 mg/kg/20D-I
TOXIC EFFECTS :
   Brain and Coverings - increased intracranial pressure
   Sense Organs and Special Senses (Eye) - visual field changes
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 22,345,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 40 mg/kg/2W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - interstitial nephritis
   Kidney, Ureter, Bladder - proteinuria
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 120 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 244,55,1990

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D:
   Sciences Naturelles.  (Paris, France)  V.262-291, 1966-80.  For publisher
   information, see CRASEV.  Volume(issue)/page/year: 272,886,1971

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,159,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ng/plate
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-341,1989

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,1,1982

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - rat Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 87500 ug/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   PESTD5 Proceedings of the European Society of Toxicology.  (Amsterdam,
   Netherlands)  V.16-18, 1975-77.  Discontinued.  Volume(issue)/page/year:
   17,405,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 75 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawach

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1740 mg/kg
SEX/DURATION            : male 8 week(s) pre-mating
                          female 2 week(s) pre-mating  - 2 week(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1920 mg/kg
SEX/DURATION

其他信息

用途三:本品为合成抗菌药，抗菌谱较广，对大多数革兰阳性菌及阴性菌均有抗菌作用，如金葡菌、大肠杆菌、白色葡萄球菌及化脓性链球菌等。临床上用于敏感菌所致的泌尿系统感染，如肾盂肾炎、尿路感染、膀胱炎及前列腺炎等。校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。
MSDS 信息:Nitrofurantoin(67-20-9).msds
上游原料:丙酮 --> 水合肼 --> 氯乙酸乙酯 --> 糠醛 --> 氨基脲 --> 5-硝基糠醛二乙酸酯 --> 丙酮缩氨基脲
用途一:是优良的抗菌药，抗菌谱较广，适用于泌尿道感染，如肾盂肾炎、肾盂炎及膀胱炎等
方法一:由水合肼与尿素缩合生产氨基脲，再与丙酮缩合制得丙酮缩氨基脲。然后与氯乙酸乙酯环合成丙酮缩乙内酰脲，经水解后与5-硝基糠醛二乙酸酯缩合得呋喃妥因。
在100ml下列溶剂中可溶解的毫克书：水19.0，95%乙醇51.0，丙酮510，DMF8000。几乎不溶于氯仿。遇光颜色变深，无色，味苦。
color:yellow
Sigma Aldrich:67-20-9(sigmaaldrich)
用途二:该品是一种优良的抗菌药物，口服后吸收迅速而完全，排泄也较快，在尿中排出量可达40-50%，常用于治疗各种敏感细菌引起的尿路感染，对以大肠杆菌引起的急性尿路感染，疗效较好。
呋喃妥因价格(试剂级):更新日期产品编号产品名称包装价格 2010/05/25 B24079 呋喃妥英, 98% Nitrofurantoin, 98% 500g 5446元 2010/05/25 B24079 呋喃妥英, 98% Nitrofurantoin, 98% 25g 403元 2010/05/25 B24079 呋喃妥英, 98% Nitrofurantoin, 98% 100g 1330元
Alfa Aesar:呋喃妥英,98% Nitrofurantoin, 98%(67-20-9)
MOL 文件:67-20-9.mol