Testosterone Propionate 丙酸睾酮
CAS 57-85-2 MFCD00003653
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Androgen, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Lipids, Steroid Hormones, Steroids (C19) and Derivatives, Sterol Lipids, T
- {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 13ring; 14ring; 17ring; ester; ketone; chiral; 1fragment
- {SNA} Androgen, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Lipids, Steroid Hormones, Steroids (C19) and Derivatives, Sterol Li
产品应用
- 用于治疗乳腺癌、卵巢癌、子宫肌瘤、多发性骨髓瘤及肾癌等。丙酸睾丸酮已被用于研究对怀孕母羊的影响作用
相关文献及参考
- Short: III/5b
- Merck:13,9255
- Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977),
- Short: EINECS
- Merck:13,9255 Beilstein:8(3)897
- Merck 14 ,9180
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H332 Harmful if inhaled 吸入有害
- H350 May cause cancer 可能致癌
- H351 Suspected of causing cancer 怀疑致癌
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P203
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312
- P301+P317
- P302+P352
- P304+P312
- P304+P340
- P308+P313
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P317
- P318
- P319
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- R45 May cause cancer 可能致癌
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R22 Harmful if swallowed 吞咽有害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Musculoskeletal - tumors Reproductive - Tumorigenic effects - other reproductive system tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 25,141,1965
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors REFERENCE : JSONDX Journal of Soviet Oncology. (New York, NY) V.1-5, 1980-84. Volume(issue)/page/year: 5,396,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 432 mg/kg/48W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - prostate tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,1929,1977
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5200 mg/kg/65W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Reproductive - Tumorigenic effects - uterine tumors REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 192,1
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,487,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs).
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,487,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 970 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,487,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,487,1982
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Fish - not otherwise specified DOSE/DURATION : 500 ug REFERENCE : BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16, 1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Unreported TEST SYSTEM : Fish - not otherwise specified DOSE/DURATION : 500 ug REFERENCE : BEXBBO Biochemistry and Experimental Biology. (Padua, Italy) V.10-16, 1971/72-80. Suspended. Volume(issue)/page/year: 15,329,1980
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - rat DOSE/DURATION : 10 mg/kg REFERENCE : AMTUA3 Acta Medica Turcica. (Dr. Ayhan Okcuoglu, Cocuk Hastalikari Klinigi, c/o Ankara Univ., Tip Facultesi, Cebeci, Ankara, Turkey) V.1-10/11, 1948-58; New series: V.1- 1964- Volume(issue)/page/year: 8,68,1971
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 1 mg/L REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 16,1329,1995
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 300 umol/L REFERENCE : SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE : 92 mg/kg SEX/DURATION : male 23 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 29,409,1941
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 20 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 23,327,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE : 6250 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes REFERENCE : JPHYA7 Journal of Physiology. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1878- Volume(issue)/page/year: 172,393,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE : 1500 ug/kg SEX/DURATION : female 27-29 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - postpartum Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants p
其他信息
- MSDS 信息:17-(1-Oxopropoxy)-(17b)-androst-4-en-3-one(57-85-2).msds
- MOL 文件:57-85-2.mol
- 外观性质:白色或淡黄色结晶性粉末。不溶于水,易溶于醇、醚、吡啶、植物油。熔点:118~122℃
- color:white
- 不溶于水,易溶于醇、醚、吡啶、植物油。
- TCI Shanghai:丙酸睾酮酯 Testosterone Propionate,>;98.0%(GC)(E)(57-85-2)
- 丙酸睾丸素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T0028 丙酸睾酮酯 Testosterone Propionate 5G 857元 2011/04/16 T0028 丙酸睾酮酯 Testosterone Propionate 25G 2540元
- 药理作用:丙酸睾丸素又称丙酸睾酮、丙酸睾丸酮,常温下为白色结晶或类白色结晶性粉末,无臭。不溶于水,易溶乙醇或乙醚,略溶于植物油,极易溶于氯仿。药理作用与甲睾酮相似,但作用较后者略强。因口服易被肝脏破坏,故口服无效。常肌注其油溶液,吸收缓慢,作用强而持久,可维持时间数日。丙酸睾丸素能促进男性器官及第二性征的发育,促进蛋白质合成及骨质形成,对抗雌激素,抑制子宫内膜生长及卵巢、垂体功能。用于无睾症、隐睾症、男性性腺机能减退症、妇科疾病如月经过多、子宫肌瘤、老年性骨质疏松及再生障碍性贫血等。 本品在体内先转化为5α-二氢睾酮 (5α-dihyrotesterone),以后再与细胞受体结合,进入细胞核,与染色质作用,激活RNA多聚酶,促进蛋白质合成和细胞代谢。此外,丙酸睾酮可通过红细胞生成素刺激红细胞的生成和分化。丙酸睾丸素口服虽可吸收,但在肝中会迅速破坏而失效,故一般采用肌内注射。肌内注射丙酸睾酮后,吸收较慢,其延效时间2~4日。在血中,98%的睾酮与性激素球蛋白结合,仅2%为游离状。半衰期为10~20min。睾酮在肝内灭活后,代谢产物为雄酮、异雄酮及原胆烷醇酮。它们90%是与葡萄醛酸及硫酸结合的形式从尿中排出。约6%非结合形式的产物是由胆汁排出,其中少部分仍可再吸收,形成肠肝循环。
- Sigma Aldrich:57-85-2(sigmaaldrich)
- 用途一:用于治疗乳腺癌、卵巢癌、子宫肌瘤、多发性骨髓瘤及肾癌等。