CAS 79-10-7 MFCD00004367-Acrylic Acid 丙烯酸 TAO{mole}

Acrylic Acid 丙烯酸

CAS 79-10-7 MFCD00004367

化学结构图

SMILES: C=CC(=O)O

化学属性

Mol. Formula	C3H4O2
Mol. Weight	72.06
Boiling Point	139
Density	1.051
Melting Point	13
Refractive index	1.4190 to 1.4220
Autoignition Point	744 °F
Vapor Density	2.5 (vs air)
Vapor Pressure	4 mmHg ( 20 °C)
Flash Point	54.44°C
TSCA	Yes
Solubility	Soluble in water, chloroform, ethanol, methanol, and DMF.
Stability	易吸潮,对光线、空气敏感

别名和识别编码

Chemical Name	Acrylic Acid
CAS Number	79-10-7
PubChem Substance ID	6581
EC Number	201-177-9
Beilstein Registry Number	635743
MDL Number	MFCD00004367
Synonym	Acrylic acid {LY} Acrylic acid Acrylic acid, glacial Acrylsαure CH2=CHCOOH ETHYLENECARBOXYLIC ACID Ethylenecarboxylic acid Glacial acrylic acid Kyselina akrylova PROPENOIC ACID Propene acid Propenoic acid RARECHEM AL BO 0141 RCRA waste number U008 Vinylformic acid acideacrylique acideacrylique(french) acidoacrilio acrylicacid,[waste] acrylicacid,glacial acrylicacid,inhibited ai3-15717 caswellno.009a {} {LY} Acrylic acid {} {} {LY} Acrylic acid {} {} {} {LY} Acrylic acid {} {} {} {} {LY} Acrylic acid {} {} {} {} {} {LY} Acrylic acid {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Acrylic acid {} {} {} {} {} {} {} {LY} Acrylic acid {} {} {} {} {} {} {} {} {LY} Acryli
Merck Number	130
Reaxys-RN	635743
Chemical Name Translation	丙烯酸
Wiswesser Line Notation	QV1U1
LabNetwork Molecule ID	LN00195907
InChI	InChI=1S/C3H4O2/c1-2-3(4)5/h2H,1H2,(H,4,5)
Canonical SMILES	C=CC(O)=O

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产品应用

Usually used in preparing monodispersed poly (N-isopropylacryamide) (PNIPAM)/AAc microgels.And also used primarily as an intermediate in the production of acrylates.

安全信息

GHS Symbol

WGK Germany1

Hazard Codes C,N

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H335 May cause respiratory irritation 可能导致呼吸道刺激
H226 Flammable liquid and vapour 易燃液体和蒸气
H302+H312+H332

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSAS4375000

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P303+P361+P353
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P304+P340+P310
P403+P233

Signal word

Packing GroupII

UN Number

Risk Statements

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class8/3

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37440 mg/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - leukemia
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0386-0592

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2912 mg/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   61,189,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37440 mg/kg/78W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0386-0592

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   28,313,1974

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue)/page/year: 51,1632,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,16,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 49(10),64,1984

TYPE OF TEST

{hazard_co

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 116 mg/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   30,505,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 450 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,49,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,49,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 169 gm/kg
SEX/DURATION            : male 13 week(s) pre-mating
                          female 13 week(s) pre-mating  - 3 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - physical
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 6,1,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7329 ug/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue)/page/year: 51,1632,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14340 ug/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue)/page/year: 51,1632,1972

Warnings 危化品目录(2015) 危险化学品

其他信息

丙烯酸的生产方法:乙炔羰化法乙炔、一氧化碳、水和溶剂四氢呋喃、以卤化镍（见络合催化剂）为催化剂，卤化铜作助催化剂，在160～200℃、4.0～5.5MPa下,通过羰化（见羰基合成）得到丙烯酸：CH≡CH+H2O+CO─→CH2＝ CHCOOH此法正逐渐被丙烯氧化法所取代。丙烯腈水解法丙烯腈在硫酸存在下，进行二次水解再经减压蒸馏可得纯丙烯酸：CH2＝CHCN+H2O+H2SO4─→CH2＝CHCONH2·H2SO4 CH2＝CHCONH2·H2SO4+H2O─→CH2＝CHCOOH+NH4HSO4 近年，由于丙烯氨化氧化制丙烯腈工艺迅速发展，为丙烯酸生产提供了廉价的丙烯腈。丙烯腈水解法丙烯腈在硫酸存在下，进行二次水解再经减压蒸馏可得纯丙烯酸： CH2＝CHCN+H2O+H2SO4─→CH2＝CHCONH2·H2SO4 CH2＝CHCONH2·H2SO4+H2O─→CH2＝CHCOOH+NH4HSO4 近年，由于丙烯氨化氧化制丙烯腈工艺迅速发展，为丙烯酸生产提供了廉价的丙烯腈。丙烯氧化法分两步进行:第一步用钼-铋系或锑系催化剂,使丙烯氧化为丙烯醛;第二步用钼-钒-钨系催化剂（见金属氧化物催化剂）使丙烯醛氧化为丙烯酸： CH2＝CHCH3+O2─→CH2＝CHCHO+H2O CH2＝CHCHO+2O2─→CH2＝CHCOOH 丙烯、蒸汽和预热空气混合进入第一反应器（见下图）,反应温度320～340℃,压力270kPa,反应气不经分离直接送入第二反应器,反应温度280～360℃，压力200kPa。两个反应器均用熔盐作载热体。
刺激数据:皮肤-兔子 500 毫克重度; 眼睛-兔子 1 毫克重度 (参考: 丙烯酸)
Sigma Aldrich:79-10-7(sigmaaldrich)
储运特性:库房通风低温干燥; 与氧化剂分开储运
外观性质:无色液体，有刺激性气味。
概述:丙烯酸是化学式为CH2=CHCOOH的有机化合物，是最简单的不饱和羧酸，由一个乙烯基和一个羧基组成。纯的丙烯酸是无色澄清液体，带有特征的刺激性气味。密度1.0511。熔点14℃。沸点140.9℃。酸性较强。有腐蚀性。溶于
敏感性:Air Sensitive
MOL 文件:79-10-7.mol
灭火剂:雾状水、二氧化碳、泡沫、干粉
vapor pressure:4 mm Hg ( 20 °C)
毒性分级:高毒
概述:丙烯酸是最简单的不饱和羧酸，分子结构为一个乙烯基和一个羧基组成。纯的丙烯酸是无色澄清液体，带有特征的刺激性气味。密度1.0511。熔点14℃。沸点140.9℃。酸性较强。有腐蚀性。溶于水、乙醇和乙醚。化学性质活泼。易聚合而成透明白色粉末。还原时生成丙酸。与盐酸加成时生成2-氯丙酸。用于制备丙烯酸树脂等，也用于其他有机合成。由丙烯醛氧化或由丙烯腈水解而得，也可由乙炔、一氧化碳和水合成，或由乙烯和一氧化碳加压氧化而制得。丙烯酸可发生羧酸的特征反应，与醇反应也可得到相应的酯类。最常见的丙烯酸酯包括丙烯酸甲酯、丙烯酸丁酯、丙烯酸乙酯和丙烯酸-2-乙基己酯。丙烯酸及其酯类自身或与其他单体混合后，会发生聚合反应生成均聚物或共聚物。通常可与丙烯酸共聚的单体包括酰胺类、丙烯腈、含乙烯基类、苯乙烯和丁二烯等。这类聚合物可用于生产各式塑料、涂层、粘合剂、弹性体、地板擦光剂及涂料。
丙烯酸涂料:丙烯酸涂料主要有热塑性丙烯酸涂料、热固性丙烯酸涂料、高固体份丙烯酸涂料、丙烯酸酯乳胶漆、水稀释丙烯酸树脂涂料。（1）热塑性丙烯酸涂料主要组分是聚甲基丙烯酸甲酯，但单纯的聚甲基丙烯酸甲酯太脆，且对底材的附着力差，溶剂不易发挥尽，原因是其玻璃化转变温度高。溶剂型热塑性丙烯酸涂料的固体含量太低(体积浓度为12% 左右)，进入20世纪70年代后用量急剧下降，代之而发展的是热固性丙烯酸涂料，特别有前途的是高固体份的丙烯酸涂料。（2）热固性丙烯酸树脂可以提高涂料的不挥发物含量，涂料施工后在固化过程中发生交联。热固性丙烯酸涂料除了有较高的固体份以外，
气味有较强刺激味。对光敏感。能发烟。在氧存在下极易聚合。能与水、乙醚、乙醇任意混溶。化学性质活泼。易聚合。有腐蚀性。商品常加入一定量阻聚剂作稳定剂。