3,4-Dihydroxycinnamic Acid 咖啡酸
CAS 331-39-5 MFCD00004392
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Analytical Reagents, Analytical/Chromatography, Bioactive Small Molecules, C-CH, Cell Biology, Mass Spectrometry, Mass Spectrometry (MS), Matrices for MALDI Analysis, Matrix Substances for MALDI-MS, Molecular Biology, Proteomics, Spectroscopy
- {SNA} Allium
- {SNA} Allium cepa (Onion),
产品应用
- 一种天然的存在于植物中的酚酸化合物,是一种抗氧剂,抑制白三烯(leukotrienes)的合成(白三烯涉及到免疫、发炎和敏感症的调控), 抑制 Cu2+-诱导的 LDL的氧化。
相关文献及参考
- [2]. Liang G, et al. The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. Behav Brain Funct. 2015 Apr 18;11:18.
- Krasemann, et al.: Arch. Pharm., et al.: 293, 721 (1960),
- Merck: 14,1635
- Merck: 14,1635 Beilstein:10,436
- Neish, et al.: Can. J. Biochem Physiol., 37, 1431 (1959),
- Wolfrom, et al.: J. Agric. Food Chem., 8, 58 (1960),
- [1]. Pradhananga S, et al. Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice. Eur J Pharmacol. 2015 Sep 5;762:313-21.
- [1]. Pradhananga S, et al. Caffeic acid exhibits anti-pruritic effects by inhibition of multiple itch transmission pathways in mice. Eur J Pharmacol. 2015 Sep 5;762:313-21.
- [2]. Liang G, et al. The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. Behav Brain Funct. 2015 Apr 18;11:18.
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H351 Suspected of causing cancer 怀疑致癌
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P302+P350
- P302+P352
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P308+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1613 gm/kg/96W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,5655,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 728 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 51,5655,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >721 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,227,1976
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 200 mg/L REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 14,251,1981
TYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 300 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 135,109,1984
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 307 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,219,1988
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 480 mg/kg SEX/DURATION : female 5-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,227,1976
其他信息
- 咖啡酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C0002 咖啡酸 Caffeic Acid 5G 235元 2014/06/02 C0002 咖啡酸 Caffeic Acid 25G 986元 2010/06/21 114930250 咖啡酸 3,4-Dihydroxycinnamic acid 99+%, predominantly trans isomer 25 GR 1538元
- MSDS 信息:Caffeic acid(331-39-5).msds
- HPLC法测定蒲公英中咖啡酸的含量:[供试品] 菊科植物蒲公英Taraxacum mongolicum Hand. Mazz.,碱地蒲公英T. sinicum Kitag。 (1) 色谱条件:用十八烷基硅烷键含硅胶为填充剂;甲醇-磷酸盐缓冲液(磷酸二氢钠1.56g,加水使溶解成1000ml,再加1%磷酸溶液调节pH值至3.8~4.0,即得) (23:77)为流动相;检测波长为323nm;柱温40℃。理论板数按咖啡酸峰计算,不低于3000。 (2) 对照品溶液的配制:取咖啡酸对照品7.5mg,精密称定,置50ml量瓶中,加甲醇至刻度,摇匀;精密量取2ml,置10ml量瓶中,加甲醇至刻度,摇匀,即得(
- 储运特性:库房通风低温干燥
- 提取方法:咖啡酸为常见酚酸类化合物,有提升白细胞的作用,易与咖啡碱混淆。在植物界中普遍存在,主要来源于柠檬果皮、毛莨科植物升麻根茎、缬草根等多种植物。咖啡酸与阿魏酸、芥子酸、对羟基桂皮酸是在植物中几乎普遍存在羟基桂皮酸,此类产品分子结构的侧链上有共轭双键,在紫外光下显荧光,多数呈蓝色荧光。这是纸色谱或薄层色谱检查的有利条件。 提取方法: 单穗升麻根茎用甲醇提取,减压浓缩去甲醇。残留物加热水使溶,趁热滤除不溶物。冷却后加苯萃取,苯溶液用1%碳酸氢钠水溶液洗涤,收集洗涤液。加稀盐酸酸化,用苯再从中游离出的有机酸,减压浓缩去苯,残留物为咖啡酸富集制品。
- 毒性分级:中毒
- Alfa Aesar:3,4-二羟基苯乙烯酸,99% 3,4-Dihydroxycinnamic acid, predomina
- 可燃性危险特性:热分解辛辣刺激烟雾
- HPLC法测定蒲公英中咖啡酸的含量:[供试品] 菊科植物蒲公英Taraxacum mongolicum Hand. Mazz.,碱地蒲公英T. sinicum Kitag。 (1) 色谱条件:用十八烷基硅烷键含硅胶为填充剂;甲醇-磷酸盐缓冲液(磷酸二氢钠1.56g,加水使溶解成1000ml,再加1%磷酸溶液调节pH值至3.8~4.0,即得) (23:77)为流动相;检测波长为323nm;柱温40℃。理论板数按咖啡酸峰计算,不低于3000。 (2) 对照品溶液的配制:取咖啡酸对照品7.5mg,精密称定,置50ml量瓶中,加甲醇至刻度,摇匀;精密
- Sigma Aldrich:331-39-5(sigmaaldrich)
- Acros Organics:3,4-二羟基肉桂酸/ 咖啡酸 3,4-Dihydroxycinnamic acid, predominantly trans isomer, 99+%(331-39-5)
- 升白细胞药:咖啡酸也是一种止血升白细胞药,具有收缩凝固微血管、提高凝血因子功能、升高白细胞和血小板的作用。适用于外科手术时预防出血或止血,以及内科、妇产科等出血性疾病的止血。也用于各种原因引起的白细胞减少症、血小板减少症。
- Hazard Note:Irritant
- 图谱信息:咖啡酸(331-39-5)红外图谱(IR2) 咖啡酸(331-39-5)质谱(MS) 咖啡酸(331-39-5)红外图谱(IR1) 咖啡酸(331-39-5)核磁图( 1 HNMR)
- 易溶于热水、冷乙醇,微溶于冷水。碱溶液从黄色变成橙色。194℃软化,223~225℃分解。有刺激性。有致癌可能性。
- {Chemi
- 急性毒性:腹腔-大鼠 LDL0: 1500 毫克/公斤
- MOL 文件:331-39-5.mol
- 用途二:咖啡酸的中间体。用于有机合成。