Glutaric Acid 戊二酸

CAS 110-94-1 MFCD00004410

化学结构图

110-94-1
SMILES: O=C(O)CCCC(=O)O

化学属性

Mol. FormulaC5H8O4
Mol. Weight132.12
Density1.316
TSCAYes
Boiling Point302.9°C at 760 mmHg
Melting Point95-98°C
Solubility易溶于无水乙醇,溶于苯、氯仿、醇、醚。
Flash Point200°C/20mm

别名和识别编码

Chemical NameGlutaric Acid
CAS Number110-94-1
EC Number203-817-2
Beilstein Registry Number1209725
MDL NumberMFCD00004410
Synonym Glutaric acid {LY} Glutaric acid {} {LY} Glutaric acid {} {} {LY} Glutaric acid {} {} {} {LY} Glutaric acid {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Glutaric acid {} {} {} {} {} {} {} {} {} {} {}
Merck Number4473
PubChem Substance ID743
Reaxys-RN1209725
Chemical Name Translation戊二酸
Wiswesser Line NotationQV3VQ
LabNetwork Molecule IDLN00193417
InChIInChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9)
Canonical SMILESO=C(O)CCCC(O)=O
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分类

  • {SNA} Building Blocks, C1 to C5, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Organic Building Blocks
  • {SNA} Acid, Acids and Esters, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, CRM for chromatography, Certified Reference Materials (CRMs), Chromatography, Flavors and Fragrances, Food & Beverage Standards, Food Products & Beverages, Fruits, G-L, Grape, Natural Products, Organic Acids, Organic CRMs Alphabetical, Organic CRMs TraceCERT, Substance Classification
  • {SNA} Acid,
  • {SNA} A-L,

相关文献及参考

  • [2]. Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101.
  • [3]. Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707.
  • Merck:14,4473
  • Merck:14,4473 Beilstein: 2,IV,1934
  • Short: II/3
  • Short: III/38B
  • Short: III/5a
  • [1]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78.
  • [1]. Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78.
  • [2]. Boy N, et, al. Proposed recommendations for diagnosing a

安全信息

Signal word
GHS Symbol
WGK Germany1
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P332+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
RTECSMA3740000
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H315 Causes skin irritation 会刺激皮肤
  • H303 May be harmfully swallowed 吞食可能有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   34,1196,1940

其他信息

  • 戊二酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30092626 戊二酸;胶酸 100g 99.5元 2011/04/16 G0245 戊二酸(约50%的水溶液,约4.3mol/L) Glutaric Acid (ca. 50% in Water, ca. 4.3mol/L) 500G 663元 2011/04/16 G0069 戊二酸 Glutaric Acid 25G 180元
  • 常规方法:参见“己二酸”。
  • Sigma Aldrich:110-94-1(sigmaaldrich)
  • 下游产品:丁螺环酮 --> 环庚草醚 --> 戌二酸酐 --> 壬二酸 --> 虫胶红色素 --> 巴氯芬
  • 防护措施:有毒。将戊二酸注入家兔皮下,发现对肾有剧烈的毒害。严禁口服,操作人员应戴口罩及橡胶手套。
  • 方法一:工业上可从生产已二酸的副产品中回收。实验室制备可有多种方法。1.由γ-丁内酯制备戊二酸将γ-丁内酯和氰化钾加热至190-195℃,搅拌反应2h。冷却,加入浓盐酸酸化生成戊二酸单酰胺,再加热水解即得戊二酸。收率71-75%。2.由二氢吡喃制备戊二酸将二氢吡喃与0.2N硝酸在沸水浴上加热溶解,然后在冰水浴上冷却,加入浓硝酸,二氢吡喃水解并逸出二氧化氮,当温度降至0℃时,加入硝酸钠,强烈搅拌3h。不再冷却,使温度升至25-30℃。减压蒸发、冷却,得戊二酸,收率70-75%。3.由戊二腈制备戊二酸将戊二腈与盐酸加热回流4h,然后蒸发至干,残留物含戊二酸和氯化铵,用热乙醚提取,提取液回收乙醚即得戊二酸,可用氯仿或苯重结晶。4.环己酮氧化法环己酮经硝酸氧化生产己二酸时副产戊二酸。5.副产回收法石蜡氧化生产氧化石蜡时回收戊二酸。回收方法一般采用水萃取法(或蒸馏、闪蒸和水蒸气蒸馏等)和结晶法。6.环戊酮液相氧化法。7.二氢呋喃法。实验室中也用1,3-丙二醇制备戊二酸。
  • Acros Organics:戊二酸 Glutaric acid, 99%(110-94-1)
  • MOL 文件:110-94-1.mol
  • 外观性质:无色结晶固体。
  • 图谱信息:戊二酸(110-94-1)Raman光谱 戊二酸(110-94-1)核磁图( 13 CNMR) 戊二酸(110-94-1)核磁图( 1 HNMR) 戊二酸(110-94-1)红外图谱(IR1) 戊二酸(110-94-1)质谱(MS) 戊二酸(110-94-1)红外图谱(IR2)
  • Alfa Aesar:戊二酸,99% Glutaric acid, 99%(110-94-1)
  • MSDS 信息:戊二酸(110-94-1).msds
  • 用途三:戊二酸(110-94-1)用于制备戊二酸酐、α-酮戊二酸、过氧戊二酸、B-(4-氯苯基) 戊二酸以及制成抗血压剂的中间体。作为引发剂,用合成树脂、合成橡胶 和增塑剂。在塑料工业方面,由于戊二酸(110-94-1)具有良好相溶性和温和的化学性可作清洗剂材料。
  • 易溶于无水乙醇和乙醚,溶于苯和氯仿,微溶于石油醚。存在于甜菜汁中。
  • 上游原料:硝酸 --> 氯化铵 --> 氰化钾 --> 环己酮 --> 石蜡 --> 己二酸 --> 环戊酮 --> gamma-丁内酯 --> 1,3-丙二醇 --> 四氧化二氮 --> 2,3-二氢呋喃 --> 二氢吡喃 --> 戊二腈 --> 氧化石蜡
  • 用途一:主要用于制取戊二酸酐
  • 用途四:用于有机合成,制备戊二酸二甲酯及戊二酸二乙酯等,经脱水可制得戊二酸酐。也用作合成酸树酯及合成橡胶时的引发剂。
  • 海关编码:29171990
  • 用途二:生产戊二酸酐的原料,用作合成树脂、合成橡胶聚合时的引发剂。
  • TCI Shanghai:戊二酸(约50%的水溶液,约4.3mol/L) Glutaric Acid (ca. 50% in Water, ca. 4.3mol/L)(110-94-1)

系列性分类