(1R,2S)-(-)-N-Methylephedrine 甲基麻黄碱溶液,100ppm

CAS 552-79-4 MFCD00004504

化学结构图

552-79-4
SMILES: C[C@@H]([C@H](O)c1ccccc1)N(C)C

化学属性

Mol. FormulaC6H5CH(OH)CH(CH3)N(CH3)2
Mol. Weight179.26
Melting Point86-88 °C(lit.)
TSCANo
Appearance 熔点63.5-64.5℃。其盐酸盐为白色针状结晶或结晶性粉末,熔点207-208℃。易溶于水、乙醇、冰乙酸,微溶于氯仿或丙酮。无臭,味苦。

别名和识别编码

Chemical Name(1R,2S)-(-)-N-Methylephedrine
Synonym (-)-1R,2S-METHYLEPHEDRINE (IR,2S)-I-N-Methylephedrine Base (1Rs,2Rs)-2-dimethylamino-1-phenylpropan-1-ol METHYLEPHEDRINE [R-(R*,S*)]-ALPHA-[1-(DIMETHYLAMINO)ETHYL]BENZENEMETHANOL (1R,2S)-(-)-N-METHYLEPHEDRINE (-)-(1R,2S)-2-二甲基氨基-1-苯丙醇 (-)-N-甲基麻黄碱 [R-(R*,S*)]-α-[1-(二甲基氨基)乙基]苯甲醇 (-)-(1R,2S)-2-DIMETHYLAMINO-1-PHENYL-1-PROPANOL 甲基麻黄碱 N,N-Dimethylnorephedrine Erythro-alpha-[1-(dimethylamino)ethyl]benzyl alcohol (-)-N-甲基麻黄碱,98+% -[1-(Dimethylamino)ethyl]benzenemethanol METHYLEPHEDRINE, (-)-1R,2S- 2-(Dimethylamino)-1-phenyl-1-propanol (-)-(1R,2S)-2-DIMETHYLAMINO-1-PHENYLPROPANOL (-)-(1R,2S)-2-二甲基氨基-1-苯丙醇 (-)-N-甲基麻黄碱 [R-(R*,S*)]-α-[1-(二甲基氨基)乙基]苯甲醇 哮喘特灵 METHYLEPHEDRINE, (-)-1R,2S N- (1R,2S)-(-)-N-甲基麻黄碱 N,N-Dimethylnorephedrine2-dimethylamino-1-phenylpropanol 甲基麻黄素 4-甲麻黄碱 (-)-ALPHA-[1-(DIMETHYLAMINO)ETHYL]BENZENEMETHANOL L-N-METHYLEPHEDRINE Benzenemethanol, alpha-[1-(dimethylamino)ethyl]-, [R-(R*,S*)]- 甲麻黄碱 (-)-N-METHYLEPHEDRINE (-)-1R,2S N-METHYLEPHEDRINE
MDL NumberMFCD00004504
PubChem Substance ID24854088
Beilstein Registry Number3031197
EC Number209-022-7
CAS Number552-79-4
Merck Number14,6068
Chemical Name Translation甲基麻黄碱溶液,100ppm
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分类

  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition Moisture Sensitive Refrigerator (+4°C)
Hazard Codes Xi
Packing GroupIII
Hazard Class6.1(b)
UN Number 1544
Restrict 易制毒化学品

其他信息

  • MOL 文件:552-79-4.mol
  • F:3
  • 甲基麻黄碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 41570 (-)-N-甲基麻黄碱,98+% (-)-N-Methylephedrine, 98+% 1g 284元
  • Alfa Aesar:(-)-N-甲基麻黄碱,98+% (-)-N-Methylephedrine, 98+%(552-79-4)
  • 方法一:将伪麻黄碱的结晶母液蒸发浓缩,得到的沉淀物加8倍水煮沸,半小时后充分自然冷却,分离析出的结晶,用水冲洗,得混合麻黄碱粗品。将粗品加水加热溶解,加盐酸对pH=7,用活性炭脱色,加氯化钙饱和溶液除草酸盐,加硫化钠饱和溶液除铁盐,搅拌5min后静置8h,滤除杂质。滤液加盐酸至pH=6-6.5,再加活性炭脱色一次。滤除炭渣后将滤液减压浓缩,放冷结晶,分离,用蒸馏水重结晶,得甲基麻黄碱盐酸盐。
  • 下游产品:麻黄碱
  • 上游原料:伪麻黄碱 --> 麻黄碱盐酸盐
  • 图谱信息:甲基麻黄碱(552-79-4)红外图谱(IR2) 甲基麻黄碱(552-79-4)红外图谱(IR1) 甲基麻黄碱(552-79-4)质谱(MS)
  • Acros Organics:甲基麻黄碱 (-)-N-Methylephedrine, 99%(552-79-4)
  • 敏感性:Moisture Sensitive
  • Sigma Aldrich:552-79-4(sigmaaldrich)
  • 用途一:该品具有类似麻黄碱盐酸盐扩张支气管的作用。且有更强的抗过敏和镇咳作用,而无麻黄碱协酸盐的兴奋中枢,加速心率与升高血压等作用。适用于流行性感冒、支气管喘息、过敏反应等病菌患的治疗。

系列性分类


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