alpha-Naphthoflavone 2-苯基-4H-苯并[h]苯并吡喃-4-酮
CAS 604-59-1 MFCD00004985
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分类
- {SNA} Analytical Reagents, Analytical/Chromatography, Aryl Hydrocarbon Receptor Antagonist, Benzopyrans, Bioactive Small Molecules, Building Blocks, Cancer Research, Cell Biology, Chemical Synthesis, Chemopreventive Agents, Heterocyclic Building Blocks, Indicators, N, Redox Indicators, Titration
- {uni_hamburg} no charge; oxygen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; 14ring; ketone; ether; 1fragment
- {SNA} Aryl Hydrocarbon Receptor Antagonist, Benzopyrans, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Indicators, Redox Indicators, Titration, 分析
产品应用
- An aryl hydrocarbon receptor inhibitor.
相关文献及参考
- Short: EINECS
- Short: III/35E
- Beilstein:17,390
安全信息
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 20 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3662,1987
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 40 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3662,1987
GHS Symbol
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
其他信息
- 图谱信息:α-萘黄酮(604-59-1)红外图谱(IR2) α-萘黄酮(604-59-1)红外图谱(IR1) α-萘黄酮(604-59-1)核磁图( 1 HNMR)
- 用途二:用作氧化还原指示剂。
- α-Naphthoflavone is a naturally occurring compound found in Passiflora. α-Naphthoflavone is an aryl hydrocarbon receptor antagonist and inhibitor of CYP1A1 gene expression. Experiments show inhibitory properties towards cytochrome P450 enzymes, CYP1A1 (P4501A1) and CYP1A2 (P4501A2) (competetive binding) with stimulatory activities towards CYP3A4 (P4503A4) (selective binding). α-Naphthoflavone is an inhibitor of CYP19.
- 方法一:将2g查尔酮溶于120ml乙醇,加热至沸,与盐酸混合回流24h。趁热滤掉残渣,滤液冷却结晶得到黄烷酮。然后将溴素-二硫化碳溶液加入黄烷酮中,即生成苯并黄酮。
- 用途一:用作氧化还原指标剂。
- F:8
- color:yellow
- 溶于醇及浓硫酸,溶液呈微绿色荧光。
- Hazard Note:Irritant
- MOL 文件:604-59-1.mol
- α-萘黄酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30125480 a-萘黄酮 g 750元 2011/04/16 B0056 α-萘黄酮 alpha-Naphthoflavone 5G 734元 2011/04/16 B0056 α-萘黄酮 alpha-Naphthoflavone 1G 225元
- Alfa Aesar:α-萘黄酮,97% alpha-Naphthoflavone, 97%(604-59-1)
- Acros Organics:alpha-Naphthoflavone, 99.5+%(604-59-1)
- 上游原料:2-苯基-4H-1-苯并吡喃-4-酮(黄酮) --> 2,3-二羟芴 --> 查耳酮
- TCI Shanghai:α-萘黄酮 alpha-Naphthoflavone,>;98.0%(LC)(604-59-1)
- Sigma Aldrich:604-59-1(sigmaaldrich)