1,4,7,10,13,16-Hexaoxacyclooctadecane (18-Crown-6) 18-冠醚-6
CAS 17455-13-9 MFCD00005113
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- Alkylation Reagents, Analytical Reagents, Analytical/Chromatography, Chelation/Complexation Compounds, Chemical Synthesis,
- {SNA} Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, Ion Chromatography Reagents, Salts and Additives for IC
- {SNA} Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents
- {uni_hamburg} no charge; oxygen heterocycle; alicycle; large ring; crown ether; 18ring; ether; 1fragment
- {SNA} Chromatography Reagents & Solvents, Ion Chromatography Reagents, Salts and Additives for IC, 分析/色谱, 分析试剂
- {SNA} 12 Principles Aligned Products, Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Greener Alternative Products, Synthetic Reagents
产品应用
- 大环醚类有机化合物。主要用途为精细有机合成用高效相转移催化剂、络合剂、贵金属和稀土元素分离提取用萃取剂。在化学分析中可用于离子的富集、分离和掩蔽,还可用于医药、生物化学领域以及电子工业中用作离子导电材料、液晶显示元件制作材料。
相关文献及参考
- Crown et
- Beil. 19 ,V,12,601
- Has been widely used in alkylation reactions with, e.g. K2CO3 as base:
- Has been used with KF to enhance the reactivity of F- as a base or a nucleophile, e.g. to promote Michael additions in aprotic solvents: J. Chem. Soc., Chem. Commun., 237 (1977), the condensation of nitromethane with aldehydes: Tetrahedron Lett., 3219 (1978), and the transesterification of diaryl to dialkyl phosphonates: Synthesis, 409, 412 (1982).
- Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used cata
- Crown ether (see Appendix 2) mainly used to complex potassium ions. For a comprehensive study of solvent effects on complexation with K ions in a wide range of solvents, see: J. Org. Chem., 61, 5221 (1996).
- Promotes methylation reactions with Dimethyl carbonate, A13104: Synthesis, 382 (1986). N-Alkylation of Glutarimide, L00968, and Succinimide, A13503: Bull. Soc. Chim. Fr., 227 (1992).
- Crown ether catalysis can be used in the reaction of KCN with alkyl halides to give nitriles: Tetrahedron Lett., 71 (1975), and for the preparation of acyl cyanides from acid chlorides: Tetrahedron Lett., 21, 2959 (1980). The 1:1 complex between 18-crown-6 and KCN has been used catalytically in the cyanosilylation of aldehydes, ketones and quinones with TMSCN; for examples, see: Org. Synth. Coll., 7, 517 (1990).
- Enables KH to metallate aryl-substituted methanes directly: J. Am. Chem. Soc., 99, 4457 (1977). In the presence of KOH in DME, various arylmethanes, benzyl alcohols and aldehydes are oxidized to carboxylic acids by molecular oxygen: Tetrahedron Lett., 25, 4989 (1984).
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P305+P351+P338+P337+P313
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P302+P350
- S39 Wear eye/face protection 戴眼睛/面孔保护装置;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- R36 Irritating to eyes 刺激眼睛
- R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volum
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(10),92,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intratracheal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Behavioral - tremor Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536187
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Behavioral - tremor Gastrointestinal - other changes Liver - other changes REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
其他信息
- 用途一:用作金属离子络合剂
- 用途三:大环醚类有机化合物。主要用途为精细有机合成用高效相转移催化剂、络合剂、贵金属和稀土元素分离提取用萃取剂。在化学分析中可用于离子的富集、分离和掩蔽,还可用于医药、生物化学领域以及电子工业中用作离子导电材料、液晶显示元件制作材料。
- TCI Shanghai:18-冠-6-醚 18-Crown 6-Ether,>;98.0%(GC)(17455-13-9)
- MOL 文件:17455-13-9.mol
- 检测方法:GC,NMR,MS
- 18-冠醚-6价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30203262 十八冠醚-6 100g 320元 2011/04/16 C0860 18-冠6-醚 18-Crown 6-Ether 100G 2460元 2011/04/16 C0860 18-冠6-醚 18-Crown 6-Ether 25G 880元
- MSDS 信息:Hexaoxacyclo-octadecane(17455-13-9).msds
- 上游原料:氰化钾 --> 碱金属 --> 15-冠醚-5 --> Γ-球蛋白 --> 有机碱 --> 生物化学
- 图谱信息:18-冠醚-6(17455-13-9)核磁图( 1 HNMR) 18-冠醚-6(17455-13-9)核磁图( 13 CNMR) 18-冠醚-6(17455-13-9)质谱(MS) 18-冠醚-6(17455-13-9)红外图谱(IR2) 18-冠醚-6(17455-13-9)红外图谱(IR1)
- 海关编码:29329995
- 用途二:冠醚最主要的特点之一,是可与各种金属盐、铵盐、有机阳离子化合物等形成稳定的络合物。利用这一性质,可将各种盐类溶于有机溶剂。冠醚可将阳离子螯环内,同时由于有朝外的有机基因可生成络合物,亦可溶于非极性的有机溶剂。这时,未被溶剂化的阴离子,以裸露的阴离子形式存在于溶剂中,故活性极大。冠醚可使碱金属和有机碱金属化合物溶解在有机溶剂中。因而在有机合成、光学拆分、重金属螯合、分离、分析以及生理活性的医药、生物化学等方面找到广泛的应用。例如,用作相转移催化剂,使许多在传统条件下难以反应,甚至不发生的反应,
- 存储注意事项:氮气保护
- 敏感性:Hygroscopic
- F:10
- Acros Organics:18-冠醚-6 18-Crown-6, 99%(17455-13-9)
- 下游产品:二甲基二茂铁 --> N,N-二甲基乙二胺 --> 5-溴吲唑 --> 3-苯氧基苯乙腈 --> 1,3-噻唑烷-2-酮 --> 头孢泊肟酯 --> 环氧十二烷 --> 2,4-二氨基-6-氟嘧啶 --> [(2-氧代-2H-苯并吡喃-7-基)氧基]乙酸 --> 4-甲基-3-氨基-2-氟吡啶 --> 2-氨基-4,6-二氟嘧啶 --> 2-(4-溴苯基)噻吩 --> 4-氨基-2,6-二氟嘧啶 --> N,N,N',N'-四苯基联苯胺
- 方法一:通常采用威廉林合成法制取,即用醇盐与卤代烷反应。 用途:冠醚最主要的特点之一,是可与各种金属盐、铵盐、有机阳离子化合物等形成稳定的络合物。利用这一性质,可将各种盐类溶于有机溶剂。冠醚可将阳离子螯环内,同时由于有朝外的有机基因可生成络合物,亦可溶于非极性的有机溶剂。这时,未被溶剂化的阴离子,以裸露的阴离子形式存在于溶剂中,故活性极大。冠醚可使碱金属和有机碱金属化合物溶解在有机溶剂中。因而在有机合成、光学拆分、重金属螯合、分离、分析以及生理活性的医药、生物化学等方面找到广泛的应用。例如,用作相转移催化剂,使许多在传统条件下难以反应,甚至不发生的反应,能顺利地进行,这类反应速率快、条件简单、操作方便、产率高。例如,安息香在水溶液中的缩合反应产率极低,如果在该水溶液中加入7%的冠醚,则可得到产率为78%的安息香。这一反应还可在苯(或乙腈)中进行,尽管氰化钾不溶于苯,但如果加入18-冠-6,则不仅能发生反应,而且产率可高达95%。18-冠-6的毒性:大鼠的口服致死量为300mg/kg。对眼睛、皮肤有刺激性。 #EndEditable "Content"