2-Nitroimidazole 2-硝基咪唑
CAS 527-73-1 MFCD00005185
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专业采购外包团队在线服务
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分类
- {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles
产品应用
- 用于制备硝基咪唑取代的硼酸,从而作为缺氧组织成像前体。还用于制备富含雌激素受体的肿瘤的可用位点选择性放射增敏剂。
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R25 Toxic if swallowed 吞咽有毒
- R22 Harmful if swallowed 吞咽有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310+P330
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P332+P313
- P405 Store locked up. 上锁保管。
- P305+P351+P338+P337+P313
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 316 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,478,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 9,168,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 316 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,478,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 6,182,1953
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 1 mg/plate REFERENCE : JGAMA9 Journal of General and Applied Microbiology. (Microbiology Research Foundation, c/o Japan Academic Soc. Center Bldg., 2-4-16 Yayoi, Bunkyo-ku, Tokyo, 113, Japan) V.1- 1955- Volume(issue)/page/year: 11,129,1965
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 umol/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,1,1978
其他信息
- 用途二:肿瘤放疗增敏剂米索硝唑(Misonidazole)的中间体。
- 海关编码:29332990
- Sigma Aldrich:527-73-1(sigmaaldrich)
- 上游原料:乙醇 --> 乙酸乙酯 --> 乙醚 --> 石油醚 --> 硝酸 --> 亚硝酸钠 --> 硫酸钠 --> 氟硼酸 --> 硫酸铜五水合物 --> 氨基乙醛缩二乙醇 --> 2-氨基咪唑硫酸盐 --> 乙基胍 --> 2-氨基咪唑
- 图谱信息:2-硝基咪唑(527-73-1)核磁图( 13 CNMR) 2-硝基咪唑(527-73-1)红外图谱(IR1) 2-硝基咪唑(527-73-1)红外图谱(IR2) 2-硝基咪唑(527-73-1)核磁图( 1 HNMR) 2-硝基咪唑(527-73-1)质谱(MS)
- 2-硝基咪唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 187572500 2-硝基咪唑 2-Nitroimidazole 98% 250 MG 1199元 2010/06/21 187570010 2-硝基咪唑 2-Nitroimidazole 98% 1 GR 3453元 2010/05/25 L13546 2-硝基咪唑, 98% 2-Nitroimidazole, 98% 500mg 1456元
- 用途一:用作有机合成中间体
- MOL 文件:527-73-1.mol
- 检测方法:HOLC
- 方法一:将氨基乙缩醛S-甲基异硫及水混匀,搅拌加热,减压蒸干,残留物加甲醇溶解,然后滴加丙酮,得白色结晶N-(2,2-二乙氧基乙基)胍硫酸盐,收率84.4%。取N-(2,2-二乙氧基乙基)胍硫酸盐和浓盐酸混合,搅拌加热回流,反应毕,加蒸馏水减压蒸干,再加水蒸干,残留物用无水乙醇溶解,然后滴加无水乙醚,得白色固体2-氨基咪唑,收率64.5%。2-氨基咪唑,加入氟硼酸及水,冷至-15℃以下,搅拌下滴加硝酸钠和水配成的溶液。加毕,继续搅拌。将反应生成的棕绿色溶液倒入五水合硫酸铜溶液中,边加边搅,再加入亚硝酸钠继续搅拌,反应毕,加浓盐酸调pH至2,用乙酸酯提取,提取液经无水硫酸钠干燥后回收乙酸乙酯至尽,残留物用乙醇重结晶,得2-硝基咪唑。
- MSDS 信息:Azomycin(527-73-1).msds
- Acros Organics:2-硝基咪唑 2-Nitroimidazole, 98%(527-73-1)
- Alfa Aesar:2-硝基咪唑,98% 2-Nitroimidazole, 98%(527-73-1)