4-Methyl-1H-pyrazole 4-甲基吡唑

CAS 7554-65-6 MFCD00005245

化学结构图

7554-65-6
SMILES: Cc1cn[nH]c1

化学属性

Mol. FormulaC4H6N2
Mol. Weight82.10
Refractive indexn20/D 1.495(lit.)
Boiling Point99-100 °C at 6 mmHg
Density0.993
Flash Point96°(204°F)
TSCANo
Melting Point13°C
Solubility可溶

别名和识别编码

Chemical Name4-Methyl-1H-pyrazole
CAS Number7554-65-6
Alfabeta NameMETHYLPYRAZOLE H41---
MDL NumberMFCD00005245
Synonym Fomepizole {LY} Fomepizole {} {LY} Fomepizole {} {} {LY} Fomepizole {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fomepizole {} {} {} {} {} {}
PubChem Substance ID3406
EC Number231-445-0
Beilstein Registry Number105204
Reaxys-RN105204
Merck Number4226
Chemical Name Translation4-甲基吡唑
Wiswesser Line NotationT5MNJ D1
LabNetwork Molecule IDLN00008830
InChIInChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
Canonical SMILESCC1=CNN=C1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 5ring; 1fragment
  • {SNA} Bioactive Small Molecules, Building Blocks, C3 to C5, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles, 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Building Blocks, C3 to C5, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles, 生物活性小分子, 细胞生物学
  • {SNA} Bioactive Small Molecules, Building Blocks, C3 to C5, Cell Biology, Chemical Synthesis, F, Heterocyclic Building Blocks, Pyrazoles
  • {SNA} Building Blocks,
  • {SNA} Bui

相关文献及参考

  • [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53(4):439-450.e10.
  • [3]. Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1.
  • [4]. https://www.tandfonline.com/doi/full/10.1080/24734306.2019.1705596
  • Li, T.-K., and Theorell, H. Acta Chem. Scand. 23 , 892, (1969)
  • Short: EINECS
  • Short: III/38B
  • Short: IV/18B
  • [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.
  • [1]. Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107(1):170.
  • [2]. Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. An

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUQ7350000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P330+P331
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupIII
Hazard Class6.1(b)
UN Number 2810
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 534 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 28,1198,1972

其他信息

  • Sigma Aldrich:7554-65-6(sigmaaldrich)
  • MSDS 信息:Fomepizol(7554-65-6).msds
  • 检测方法:GC
  • F:10-23
  • TCI Shanghai:4-甲基吡唑 4-Methylpyrazole,>;98.0%(GC)(7554-65-6)
  • MOL 文件:7554-65-6.mol
  • 敏感性:Hygroscopic
  • 4-甲基吡唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0774 4-甲基吡唑 4-Methylpyrazole 1G 906元 2010/06/21 206970050 4-甲基吡唑 4-Methylpyrazole 97% 5 GR 3204元 2010/06/21 206970010 4-甲基吡唑 4-Methylpyrazole 97% 1 GR 777元
  • Acros Organics:4-甲基吡唑 4-Methylpyrazole, 97%(7554-65-6)
  • Alfa Aesar:4-甲基吡唑,97+% 4-Methyl-1H-pyrazole, 97+%(7554-65-6)

系列性分类


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