CAS 497-25-6 MFCD00005268-2-Oxazolidone 2-噁唑啉酮 TAO{mole}

2-Oxazolidone 2-噁唑啉酮

CAS 497-25-6 MFCD00005268

化学结构图

SMILES: O=C1NCCO1

化学属性

Mol. Formula	C3H5NO2
Mol. Weight	87
Density	1.422
Boiling Point	220
Melting Point	83-87
TSCA	Yes
Flash Point	220°C/48mm

别名和识别编码

Chemical Name	2-Oxazolidone
CAS Number	497-25-6
Synonym	(2-hydroxyethyl)-carbamicacigamma-lactone 2-Oxazolinone 2-Oxazolidinone,99% 四氫【口+咢】唑 2-Oxazolidone (2-hydroxyethyl)-carbamic acid gamma-lactone 2-噁唑铜 2-Oxotetrahydro-1,3-oxazole 2-OXAZOLIDIONE 2-唑烷酮 2-Oxazolidine 1,3-Oxazolidin-2-one 【口+咢】唑啶酮 2-噁唑酮 Oxazolidine 2-唑酮,99% Oxazolidone 2-Oxo-1,3-oxazolidine 2-OXAZOLIDONE NSC 35382 Carbamic acid, (2-hydroxyethyl)-, gamma-lactone 2-恶唑铜 1,3-唑烷-2-酮 2-Oxazolidinone; Oxazolidin-2-one 2-OXAZOLIDINONE 2-噁唑烷酮【口+咢】唑啶 2-OX 2-噁唑啉酮 2-Oxazolidinone oxazolidin-2-one Carbamic acid, (2-hydroxyethyl)-, γ-lactone NSC 38240 2-恶唑酮 2-恶唑烷酮 2-OXAZOLIDINONE 98% 2-唑铜
EC Number	207-840-9
Beilstein Registry Number	106251
MDL Number	MFCD00005268
PubChem Substance ID	87574187
Reaxys-RN	106251
Chemical Name Translation	2-噁唑啉酮
InChIKey	IZXIZTKNFFYFOF-UHFFFAOYSA-N
Wiswesser Line Notation	T5MVOTJ
LabNetwork Molecule ID	LN00226821
InChI	InChI=1S/C3H5NO2/c5-3-4-1-2-6-3/h1-2H2,(H,4,5)

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产品应用

An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).

安全信息

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36 Irritating to eyes 刺激眼睛
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P302+P352+P333+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P333+P313
P337+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSRQ2450000

Hazard Codes Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   2,168,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   2,168,1959

其他信息

下游产品:呋喃唑酮 --> 洛莫司汀 --> 硝基呋喃代谢产物-呋喃唑酮AOZ --> 双氯乙基脲
Sigma Aldrich:497-25-6(sigmaaldrich)
海关编码:29322980
用途二:药物卡氮芥和环己亚硝脲的中间体。
图谱信息:2-唑烷酮(497-25-6)红外图谱(IR1) 2-唑烷酮(497-25-6)红外图谱(IR2) 2-唑烷酮(497-25-6)核磁图( 13 CNMR) 2-唑烷酮(497-25-6)质谱(MS)
TCI Shanghai:2-恶唑烷酮 2-Oxazolidone,>;98.0%(GC)(497-25-6)
用途一:用作有机中间体
MOL 文件:497-25-6.mol
上游原料:乙醇胺
2-唑烷酮价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 O0188 2-恶唑烷酮 2-Oxazolidone 25G 446元 2014/06/02 O0188 2-恶唑烷酮 2-Oxazolidone 500G 3870元 2010/06/21 129660250 2-唑烷酮 2-Oxazolidone 98% 25 GR 471元
Acros Organics:2-噁唑啉酮 2-Oxazolidone, 98%(497-25-6)
MSDS 信息:Oxazolidin-2-one(497-25-6).msds
Alfa Aesar:2-唑酮,99% 2-Oxazolidinone, 99%(497-25-6)
方法一:由乙醇胺与尿素环合而得。将尿素、乙醇胺及二甲基甲酰胺加入反应锅内，搅拌加热至120℃，保温2h，再升温至150-160℃回流6h，冷却减压蒸出二甲基甲酰胺后，加无水乙醇析出结晶。过滤，醇洗，干燥，得2-噁唑烷酮，收率70%左右。