(±)-α-Lipoic acid DL-α-硫辛酸
CAS 1077-28-7 MFCD00005474
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- {SA} Antioxidant, Antioxidant and Free Radical Scavengers, Antioxidants and Cytoprotectants, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Chemopreventive Agents, Cofactors, Enzymes, Inhibitors, and Substrates,
- {SNA}
产品应用
- 抗氧化剂和作为如丙酮酸脱氢酶(pyruvate dehydrogenase) 和甘氨酸脱羧酶(glycine decarboxylase)的辅酶,外源性硫辛酸被细胞内两种或多种酶还原。这种还原形式影响了细胞清除自由基的进程。增加谷胱甘肽(glutathione)合成, 调控转录因子活性。降低了巨噬细胞髓磷脂的吞噬作用。
相关文献及参考
- [2]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.
- [3]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.
- [4]. Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139.
- Merck:14,9326
- Merck:14,9326 Beilstein: 19,V,7,237
- [1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors
- [1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.
安全信息
- H302 Harmful if swallowed 吞食有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P301+P312+P330
- P302+P352
- P302+P352+P332+P313+P362+P364
- P305+
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 235 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,284,1971
其他信息
- MSDS 信息:5-(Dithiolan-3-yl)valeric acid(1077-28-7).msds
- 用途一:抗氧化剂和作为如丙酮酸脱氢酶(pyruvate dehydrogenase) 和甘氨酸脱羧酶(glycine decarboxylase)的辅酶,外源性硫辛酸被细胞内两种或多种酶还原。这种还原形式影响了细胞清除自由基的进程。增加谷胱甘肽(glutathione)合成, 调控转录因子活性。降低了巨噬细胞髓磷脂的吞噬作用。
- Acros Organics:DL-硫辛酸 DL-Thioctic acid, 98+%(1077-28-7)
- color:light yellow
- Alfa Aesar:DL-硫辛酸,99% DL-Thioctic acid, 98%(1077-28-7)
- 几乎无味。本品在水中几乎不溶,水中溶解度:1 g/L (20°C) 。溶于10% NaOH溶液,溶于脂肪族溶剂。在乙醇、氯仿、乙醚中易溶。
- Sigma Aldrich:1077-28-7(sigmaaldrich)
- MOL 文件:7516-48-5.mol
- 图谱信息:alpha-硫辛酸(1077-28-7)核磁图( 1 HNMR) alpha-硫辛酸(1077-28-7)质谱(MS) alpha-硫辛酸(1077-28-7)红外图谱(IR2) alpha-硫辛酸(1077-28-7)红外图谱(IR1) alpha-硫辛酸(1077-28-7)核磁图( 13 CNMR)
- 检测方法:HPLC
- Sigma Aldrich:7516-48-5(sigmaaldrich)
- 外观性质:淡黄色粉末状结晶,几乎无味。本品在水中几乎不溶,水中溶解度:1 g/L (20°C) 。溶于10% NaOH溶液,溶于脂肪族溶剂。在乙醇、氯仿、乙醚中易溶。熔点:62 °C
- MOL 文件:1077-28-7.mol
- TCI Shanghai:DL-α-硫辛酸 DL-alpha-Lipoic Acid,>;99.0%(T)(1077-28-7)
- alpha-硫辛酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L0471102 DL-硫辛酸, 98% 5g 577元 2011/04/16 L0058 DL-α-硫辛酸 DL-alpha-Lipoic Acid 25G 1800元 2011/04/16 L0058 DL-α-硫辛酸 DL-alpha-Lipoic Acid 5G 624元