CAS 31430-18-9 MFCD00005588-Nocodazole 诺考达唑 TAO{mole}

Nocodazole 诺考达唑

CAS 31430-18-9 MFCD00005588

化学结构图

SMILES: COC(=O)NC1NC2C=CC(=CC=2N=1)C(=O)C1=CC=CS1

化学属性

Mol. Formula	C14H11N3O3S
Mol. Weight	301
Melting Point	300 °C (dec.)

别名和识别编码

Chemical Name	Nocodazole
CAS Number	31430-18-9
Synonym	Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate Oncodazole R 17934 [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester Oncodazole Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester
MDL Number	MFCD00005588
PubChem Substance ID	24278535
Beilstein Registry Number	1085978
EC Number	250-626-5
Chemical Name Translation	诺考达唑
Wiswesser Line Notation	T56 BM DNJ CMVO1 GV- BT5SJ
Formula	C14H11N3O3S

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Nocodazole is an anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. Microtubules are one type of fibre which constitutes the cytoskeleton, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerisation. (Source: http://en.wikipedia.org/wiki/Nocodazole)

安全信息

RTECSDD6521000

GHS Symbol

Precautionary statements

P281 Use personal protective equipment as required. 使用所需的个人防护装备。

Hazard statements

H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害

WGK Germany3

Signal word Warning

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard Codes Xn

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39530 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,313,1989

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 190,137,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 4,6,1989

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mammal - species unspecified
DOSE/DURATION           : 2 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 201,423,1988

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, U

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,313,1989