5-Chlorobenzo[D]Oxazol-2-Amine 5-氯苯并[d]恶唑-2-胺
CAS 61-80-3 MFCD00005770
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分类
- {SA} Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Oxazoles
- Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Oxazoles
产品应用
- Centrally acting myorelaxant; formerly used as an antispasmodic and uricosuric. Used as a tool for assessing hepatic cytochrome P-450 activity in rodents.
相关文献及参考
- Tomaszeski, J.E., et al.: Arch. Biochem. Biophys., 176, 788 (1976),
- M van der Graaff, et al.: Drug Metab. Dispos., 14, 331 (1986),
- Merck 14 ,10199
- Aldrich MSDS 1 , 69:D / Corp MSDS 1 (1), 153:A / FT-IR 2 (3), 3648:A / FT-IR 1 (2), 698:D / FT-NMR 1 (3), 199:B / IR-Spectra (3), 1278:A / IR-Spectra (2), 1111:E / NMR-Reference 2 (2), 571:C / RegBook 1 (2), 2451:F / Sax 6 , 206 / Sigma FT-IR 1 (2), 261:B / Structure Index 1 , 388:A:3
安全信息
GHS Symbol
- H332 Harmful if inhaled 吸入有害
- H315 Causes skin irritation 会刺激皮肤
- H302 Harmful if swallowed 吞食有害
- H312 Harmful in contact with skin 皮肤接触有害
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- S36 Wear suitable protective clothing 穿戴适当的防护服;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 117 mg/kg TOXIC EFFECTS : Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 16,3
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 14 mg/kg/D TOXIC EFFECTS : Behavioral - stiffness REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 160,745,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 1607 mg/kg/34W-I TOXIC EFFECTS : Liver - jaundice, other or unclassified REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 176,874,1961
TYPE OF
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATIO
其他信息
- 苯并恶唑胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 103380010 苯并恶唑胺 2-Amino-5-chlorobenzoxazole 97% 1 GR 311元 2010/06/21 103380250 苯并恶唑胺 2-Amino-5-chlorobenzoxazole 97% 25 GR 3768元 2010/06/21 103380050 苯并恶唑胺 2-Amino-5-chlorobenzoxazole 97% 5 GR 951元
- 可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化物烟雾
- 储运特性:库房通风低温干燥
- 毒性分级:中毒
- 2-氨基-5-氯苯并噁唑
- 图谱信息:苯并恶唑胺(61-80-3)红外图谱(IR1)
- MOL 文件:61-80-3.mol
- 急性毒性:口服-大鼠LD50:782 毫克/公斤; 口服-小鼠LD50:540 毫克/公斤
- Sigma Aldrich:61-80-3(sigmaaldrich)
- 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
- 类别:有毒物品
- Acros Organics:2-氨基-5-氯苯并恶唑 2-Amino-5-chlorobenzoxazole, 97%(61-80-3)