CAS 51-03-6 MFCD00005842-Piperonylbutoxide 胡椒基丁醚 TAO{mole}

Piperonylbutoxide 胡椒基丁醚

CAS 51-03-6 MFCD00005842

化学结构图

SMILES: CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2

化学属性

Mol. Formula	C19H30O5
Mol. Weight	338
Density	1.059
Refractive index	1.4960 to 1.5010
Boiling Point	195°C/2mmHg(lit.)
Flash Point	171°C(lit.)
Solubility	<0.1 G/100 ML AT 18 ºC
TSCA	Yes

别名和识别编码

Chemical Name	Piperonylbutoxide
CAS Number	51-03-6
Synonym	5-(2-(2-丁氧基乙氧基)乙氧甲基)-6-丙基-1,3-苯并二氧杂戊环 A-[2-(2-BUTOXYETHOXY)ETHOXY]-4,5-METHYLENEDIOXY-2-PROPYLTOLUENE 3,4-亚甲二氧基-6-正丙基苄基正丁基二缩乙二醇醚 5-Propyl-4-(2,5,8-trioxa-dodecyl)-1,3-benzodioxol alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-me 3,4-Methylendioxy-6-propylbenzyl-n-butyl-diaethylenglykolaether 5-[2-(2-Butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole alpha-(2-(2-n-Butoxyethoxy)-ethoxy)-4,5-methylenedioxy-2-propyltoluene 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl- Butoxide (synergist) BUTOXIDE(R) 6-(Propylpiperonyl)-butyl carbityl ether BUTACIDE(R) 增效醚/胡椒基丁醚 3,4-亚甲二氧基-6-(丁氧乙氧乙氧甲基)丙苯
EC Number	200-076-7
Beilstein Registry Number	288063
MDL Number	MFCD00005842
PubChem Substance ID	5794
Chemical Name Translation	胡椒基丁醚
Reaxys-RN	288063
Merck Number	7476
Wiswesser Line Notation	T56 BO DO CHJ G3 H1O2O2O4
LabNetwork Molecule ID	LN00194126
InChI	InChI=1S/C19H30O5/c1-3-5-7-20-8-9-21-10-11-22-14-17-13-19-18(23-15-24-19)12-16(17)6-4-2/h12-13H,3-11,14-15H2,1-2H3

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产品应用

本品能提高除虫菊素和多种拟除虫菊酯、鱼滕酮和氨基甲酸酯类杀虫剂的杀虫活性。

安全信息

Signal word

GHS Symbol

WGK Germany3

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R24 Toxic in contact with skin 与皮肤接触有毒
R51/53
R50/53
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350
P302+P352+P310+P361+P364

Hazard statements

H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H331 Toxic if inhaled 吸入中毒
H310 Fatal in contact with skin 皮肤接触致命

Personal Protective Equipment Eyeshields, Gloves

RTECSXS8050000

Hazard Codes

UN Number UN3082 2810

Packing GroupII

Hazard Class6.1

Storage condition 0-6°C

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 262 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 124,95,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 526 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   22,293,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 263 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   68,467,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB223-159

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 7500 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJTMAQ American Journal of Tropical Medicine.  (Baltimore, MD)  V.1-31,
   1921-51.  For publisher information, see AJTHAB.  Volume(issue)/page/year:
   27,339,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 32,605,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCOC** Pesticide Chemicals Official Compendium, Association of the American
   Pesticide Control Officials, Inc., 1966.  (Topeka, KS)
   Volume(issue)/page/year: -,9

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 50 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 344,27,1995

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 500 ug/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,291,1983

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 30 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,249,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2130 mg/kg
SEX/DURATION            : female 11-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TIHEEC Toxicology and Industrial Health.  (Princeton Scientific Pub. Co.,
   POB 2155, Princeton, NJ 08540)  V.1-    1985-  Volume(issue)/page/year:
   11,175,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3600 mg/kg
SEX/DURATION            : female 11-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 19,340,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 89600 ug/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.

其他信息

增效醚价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 P0458 胡椒基丁醚 Piperonyl Butoxide 500G 1330元 2011/04/16 P0458 胡椒基丁醚 Piperonyl Butoxide 25G 187元 2010/06/21 334161000 增效醚 Piperonyl butoxide 90%, tech. 100 ML 454元
储运特性:库房通风低温干燥; 与食品原料分开储运
类别:农药
毒性分级:中毒
方法一:黄樟素在镍催化下进行高压加氢，得氢氧化黄樟素，经氯甲基化后与丁基卡必醇缩合，再经减压分馏、精制而得。
用途三:本品能提高除虫菊素和多种拟除虫菊酯、鱼滕酮和氨基甲酸酯类杀虫剂的杀虫活性。
MOL 文件:51-03-6.mol
上游原料:多聚甲醛 --> 黄樟素 --> 二乙二醇丁醚 --> 黄樟油
Acros Organics:增效醚/胡椒基丁醚 Piperonyl butoxide, tech., 90%(51-03-6)
图谱信息:增效醚(51-03-6)核磁图( 13 CNMR) 增效醚(51-03-6)核磁图( 1 HNMR) 增效醚(51-03-6)质谱(MS) 增效醚(51-03-6)红外图谱(IR1)
增效醚价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 P0458 胡椒基丁醚 Piperonyl Butoxide 500G 1160元 2014/06/02 P0458 胡椒基丁醚 Piperonyl Butoxide 25G 151元 2010/06/21 334161000 增效醚 Piperonyl butoxide 90%, tech. 100 ML 454元
MSDS 信息:胡椒基丁醚(51-03-6).msds
灭火剂:干粉、泡沫、砂土
用途二:杀虫剂。用于杀死米、麦、豆类等谷物在贮藏期间产生的虫，如谷象虫。常与杀虫剂除虫菊素合用，形成络合物以起增效作用。单用除虫菊素的杀虫(家蝇为例)死亡率为46%，如使用与本品合用的制剂(30mg+400mg)，则杀死率可达92%。通常将本品按10倍于除虫菊素的量与其混合，配制成0.05%～0.2%乳剂或粉剂使用。施用本品后，其残效性约可保持1～10个月的防虫效果。按日本规定，可用于谷类，限量为0.024g/kg(以本品计)。复配型杀虫剂的实例：本品1.2%，除虫菊素0.08%，矿物性物质98.72%(60kg谷物约拌和、喷雾使用120g)。
外观性质:淡黄色至淡褐色透明油状液体。
急性毒性:口服- 大鼠 LD50: 6150 毫克/ 公斤; 口服- 小鼠 LD50: 2600 毫克/ 公斤
TCI Shanghai:胡椒基丁醚 Piperonyl Butoxide,>;90.0%(GC)(51-03-6)
不溶于水,可溶于包括矿物油和二氯甲烷在内的大多数有机溶剂,水溶性<0.1g/100mL。对光和紫外线稳定,抗水解。本品无腐蚀性, 但在铁的容器内能变化。
Sigma Aldrich:51-03-6(sigmaaldrich)
用途一:用作杀虫增效剂