CAS 57-68-1 MFCD00006066-Sulfamethazine 磺胺二甲基嘧啶 TAO{mole}

Sulfamethazine 磺胺二甲基嘧啶

CAS 57-68-1 MFCD00006066

化学结构图

SMILES: Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

化学属性

Mol. Formula	C12H14N4O2S
Mol. Weight	278
Density	1.392
Melting Point	198-201
TSCA	Yes
Solubility	150MG/100ML (29 ºC)
Stability	对光敏感
Appearance	白色或微黄结晶或粉末。熔点176℃。几乎不溶于水（溶解度：29℃，150mg/100ml；37℃，192mg/100ml），该品在热乙醇中溶解，不溶于乙醚，易溶于稀酸或稀碱溶液。无嗅，味微苦，遇光颜色逐渐变深。

别名和识别编码

Chemical Name	Sulfamethazine
CAS Number	57-68-1
Synonym	2-(p-aminobenzenesulfonamido)-4,6-dimethylpyrimidine 4,6-Dimethyl-2-sulfanilamidopyrimidine 4,6-Dimethylsulfadiazine,Sulfadimidine 4,6-二甲基磺胺嘧啶 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺磺胺二甲嘧啶 4-AMINO-N-(4,6-DIMETHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE 4-Amino-N-(4,6-Dimethyl-2-pyrimidinyl)benzenesulfonam 4-氨基-N-(4,6-二甲基-2-嘧啶基)苯磺酰胺 A-502 Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)- Cremomethazine Diazil Diazyl N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide Pirmazin S SULFADIMIDIN Sulfadimerazine Sulfadimesine Sulfadimezine Sulfadimidine Sulfamethazine Sulfamethiazine Sulphamezathine Sulphamidine Sulphodimezine sulfadimidine sulfamethazine {PubCh
EC Number	200-346-4
Beilstein Registry Number	261304
MDL Number	MFCD00006066
PubChem Substance ID	5327
Reaxys-RN	261304
Merck Number	8905
Chemical Name Translation	磺胺二甲基嘧啶
Wiswesser Line Notation	T6N CNJ BMSWR DZ& D1 F1
LabNetwork Molecule ID	LN00220271
InChI	InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

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品牌质保精细包装现货库存一流品牌服务

产品应用

Antibacterial.

安全信息

Signal word Warning

GHS Symbol

WGK Germany2

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
P302+P352
P304+P340
P304+P341
P305+P351+P338
P308+P313
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P333+P313
P337+P313
P337+P317
P342+P311
P342+P316
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSWO9275000

Personal Protective Equipment Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Storage condition 0-10 避光保存。 0-10°C 2-8°C

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 104 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   28,157,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 419 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,455,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5000 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumor types after systemic administration not seen
   spontaneously
REFERENCE :
   ACRAAX Acta Radiologica.  (Stockholm, Sweden)  V.1-58, 1921-62.  For
   publisher information, see ACRDA8.  Volume(issue)/page/year: 37,258,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,392,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1060 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   16,804,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   27,141,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DIPHAH Dissertationes Pharmaceuticae.  (Warsaw, Poland)  V.1-17, 1949-65.
   For publisher information, see PJPPAA.  Volume(issue)/page/year: 11,149,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent

TY

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 46200 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 81,259,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6850 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-151035

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 25200 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB85-105690

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPO

其他信息

上游原料:碳酸钠 --> 乙酰丙酮 --> 环己酮 --> 磺胺脒
Sigma Aldrich:57-68-1(sigmaaldrich)
磺胺二甲嘧啶价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 S0586 磺胺二甲嘧啶 Sulfamethazine 250G 350元 2014/06/02 S0586 磺胺二甲嘧啶 Sulfamethazine 25G 110元 2010/06/21 199300250 磺胺二甲嘧啶 Sulfamethazine 99% 25 GR 341元
方法一:由磺胺脒经与乙酰丙酮环合而得。
几乎不溶于水（溶解度：29℃，150mg/100ml；37℃，192mg/ml），在热乙醇中溶解，不溶于乙醚，易溶于稀酸或稀碱溶液。无嗅，味微苦，遇光颜色逐渐变深。
图谱信息:磺胺二甲嘧啶(57-68-1)红外图谱(IR1) 磺胺二甲嘧啶(57-68-1)核磁图( 1 HNMR) 磺胺二甲嘧啶(57-68-1)核磁图( 13 CNMR) 磺胺二甲嘧啶(57-68-1)质谱(MS) 磺胺二甲嘧啶(57-68-1)红外图谱(IR2)
MOL 文件:57-68-1.mol
用途二:用于防治葡萄球菌及溶解性链球菌等的感染，对溶血性链球菌及胸膜炎球菌等细菌有抑制作用，主要治疗禽霍乱、禽伤寒、鸡球虫病等。
F:10
用途一:对溶血性链球菌、肺炎球菌及脑膜炎等细菌有抑制作用
MSDS 信息:2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine(57-68-1).msds
Acros Organics:磺胺二甲基嘧啶 Sulfamethazine, 99%(57-68-1)
Alfa Aesar:磺胺二甲基嘧啶,99% Sulfamethazine, 99%(57-68-1)