2-Amino-4,6-Dichloropyrimidine 2-氨基-4,6-二氯嘧啶

CAS 56-05-3 MFCD00006090

化学结构图

56-05-3
SMILES: Nc1nc(Cl)cc(Cl)n1

化学属性

Mol. FormulaC4H3Cl2N3
Mol. Weight163.99
Melting Point219-222°C
TSCAT
Density1.606
Appearance 纯品为白色结晶,工业品为淡黄色固体,m.p.223~225℃,受热易升华,不溶于水,溶于丙酮、二氯乙烷及热甲苯。
Boiling Point348.5°C at 760 mmHg

别名和识别编码

Chemical Name2-Amino-4,6-Dichloropyrimidine
CAS Number56-05-3
Alfabeta NameAMINODICHLOROPYRIMIDINE 246---,
MDL NumberMFCD00006090
Synonym 2-Amino-4,6-dichloropyrimidine {LY} 2-Amino-4,6-dichloropyrimidine {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Amino-4,6-dichloropyrimidine {} {} {} {} {} {} {}
EC Number200-253-9
Beilstein Registry Number25(3/4)2123
PubChem Substance ID87562909
Reaxys-RN118454
Chemical Name Translation2-氨基-4,6-二氯嘧啶
LabNetwork Molecule IDLN00121619
InChIInChI=1S/C4H3Cl2N3/c5-2-1-3(6)9-4(7)8-2/h1H,(H2,7,8,9)
Canonical SMILESClC1=CC(Cl)=NC(N)=N1
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分类

  • Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {Chemicalbook} 农药中间体: 除草剂中间体: 磺酰脲类除草剂

产品应用

  • 用于合成苄磺隆和氯嘧磺隆,四唑嘧磺隆、吡嘧磺隆(NC-311)等。

相关文献及参考

  • Beilstein: 25,IV,2123
  • Short: EINECS
  • Short: III/5a

安全信息

Warnings IRRITANT
Signal word
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
RTECSUV6260485
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0892-10223

Storage condition -20°C, sealed storage, away from moisture and light {LY} -20°C, sealed storage, away from moisture and light {} {LY} -20°C, sealed storage, away from moisture and light {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C

其他信息

  • 用途一:重要的医药中间体
  • 图谱信息:2-氨基-4,6-二氯嘧啶(56-05-3)核磁图( 1 HNMR) 2-氨基-4,6-二氯嘧啶(56-05-3)质谱(MS) 2-氨基-4,6-二氯嘧啶(56-05-3)红外图谱(IR1)
  • 用途三:2-氨基-4,6-二氯嘧啶是制备2-氨基-4,6-二甲氧基嘧啶的中间体,可用于生产磺酰脲类除草剂,如苄嘧磺隆、吡嘧磺隆、烟嘧磺隆等。
  • Sigma Aldrich:56-05-3(sigmaaldrich)
  • Alfa Aesar:2-氨基-4,6-二氯嘧啶,99% 2-Amino-4,6-dichloropyrimidine, 98%(56-05-3)
  • 用途二:用于合成氯嘧磺隆除草剂
  • 海关编码:29335995
  • 用途五:用于合成苄磺隆和氯嘧磺隆,四唑嘧磺隆、吡嘧磺隆(NC-311)等。
  • TSCA:T
  • MSDS 信息:2-Amino-4,6-dichloropyrimidine(56-05-3).msds
  • TCI Shanghai:2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine,>;97.0%(T)(56-05-3)
  • 用途四:用于合成苄磺隆和氯嘧磺隆。
  • 方法一:其制备方法是在反应釜中加入2-氨基-4,6-二羟基嘧啶、三氯氧磷和二氯乙烷,加热到82℃,将三乙胺和二氯乙烷溶液滴加到反应液中,滴加时间1 h以上,然后将混合物在82~84℃回流2h,脱溶,加水水解,过滤,水洗,干燥得成品。
  • F:10
  • MOL 文件:56-05-3.mol
  • 2-氨基-4,6-二氯嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1456 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 25G 817元 2014/06/02 A1456 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 500G 7450元 2014/06/02 A1110 2-氨基-4,6-二氯嘧啶 2-Amino-4,6-dichloropyrimidine 25G 993元
  • 上游原料:三乙胺 --> 4,6-二羟基嘧啶
  • 检测方法:HPLC,NMR
  • 下游产品:苄嘧磺隆 --> 2-氨基-4,6-二甲氧基嘧啶 --> 2-氨基-4-羟基-6-肼基嘧啶
  • Acros Organics:2-Amino-4,6-dichloropyrimidine, tech., 95%(56-05-3)

系列性分类