Pyridazine 哒嗪

CAS 289-80-5 MFCD00006463

化学结构图

289-80-5
SMILES: c1ccnnc1

化学属性

Mol. FormulaC4H4N2
Mol. Weight80.09
Density1.103 g/mL at 25 °C(lit.)
Boiling Point208°C at 760 mmHg
Melting Point−8°C
Refractive index1.5220 to 1.5260
Flash Point85°C
SolubilityMiscible with water, benzene, DMF. Soluble in alcohol, ether
TSCAYes
Stability对热和空气敏感
pH:A

别名和识别编码

Chemical NamePyridazine
CAS Number289-80-5
Alfabeta NamePYRIDAZINE
MDL NumberMFCD00006463
Synonym Pyridazine {LY} Pyridazine {} {LY} Pyridazine {} {} {LY} Pyridazine {} {} {} {LY} Pyridazine {} {} {} {} {LY} Pyridazine {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyridazine {} {} {} {} {} {} {} {}
EC Number206-025-5
Beilstein Registry Number23,89
PubChem Substance ID9259
Merck Number7969
Reaxys-RN103906
Chemical Name Translation哒嗪
Wiswesser Line NotationT6NNJ
LabNetwork Molecule IDLN00009251
InChIInChI=1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H
Canonical SMILESC1=CC=NN=C1
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Pyridazines

相关文献及参考

  • Short: II/25C
  • Short: II/27B
  • Reacts with Grignard reagents by 1,4-addition to give 4-substituted 1,4-dihydropyridazines in moderate yield: Acta Chem. Scand., 44, 279 (1990).

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSUR5267000
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Storage condition -20°C, sealed storage, away from moisture {LY} -20°C, sealed storage, away from moisture 0-10 0-10°C Refrigerator Store at room temperature {} {LY} -20°C, sealed storage, away from moisture {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, awa
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPHAW Progress in Biochemical Pharmacology.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1965-  Volume(issue)/page/year:
   1,542,1965

其他信息

  • Alfa Aesar:哒嗪,98% Pyridazine, 98+%(289-80-5)
  • Acros Organics:哒嗪 Pyridazine, 98+%(289-80-5)
  • TCI Shanghai:哒嗪 Pyridazine,>;99.0%(GC)(289-80-5)
  • Sigma Aldrich:289-80-5(sigmaaldrich)
  • 哒嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0616 哒嗪 Pyridazine 5G 365元 2014/06/02 P0616 哒嗪 Pyridazine 25G 1050元 2010/06/21 131760050 哒嗪 Pyridazine 98+% 5 GR 388元
  • 图谱信息:哒嗪(289-80-5)核磁图( 1 HNMR) 哒嗪(289-80-5)核磁图( 13 CNMR) 哒嗪(289-80-5)红外图谱(IR2) 哒嗪(289-80-5)质谱(MS) 哒嗪(289-80-5)红外图谱(IR1)
  • F:8-10
  • 下游产品:头孢唑兰 --> 左西孟旦 --> 哒草特 --> 巴嗪普令
  • 上游原料:水合肼 --> 2,5-二甲氧基-2,5-二氢呋喃
  • MOL 文件:289-80-5.mol
  • 杂环化合物:哒嗪是指含氮六元杂环吖嗪类杂环化合物,与嘧啶、吡嗪互为异构体,不溶于石油醚,易溶于甲醇、乙醇和乙醚,与水、苯和二甲基甲酰胺混溶。哒嗪是弱碱,能与苦味酸、盐酸等形成盐;哒嗪不容易发生芳香族的亲核和亲电取代反应;对高锰酸钾也很稳定;用钠或醇可被还原开链,转变为1,4-二氨基丁烷。 哒嗪广泛用作医药原料,例如长效磺胺SMP即为哒嗪的衍生物,抗疟药4-氨基噌啉、降血压药肼苯哒嗪等均是以哒嗪为原料制成的;也用作农药原料,制备除草剂“杀草敏”、“乙氨哒酮”、“溴杀草敏”、“哒草醚”、“抑芽丹”、“哒草灭”、 “达草止”、“杀虫剂”、“打杀磷”等。

系列性分类


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