N-Methylpiperidine N-甲基哌啶

CAS 626-67-5 MFCD00006491

化学结构图

626-67-5
SMILES: CN1CCCCC1

化学属性

Mol. FormulaC6H13N
Mol. Weight99
Density0.816
Refractive index1.4360 to 1.4380
Flash Point3°C
TSCAYes
Boiling Point106-107
Melting Point-50°C
Solubilitymiscible

别名和识别编码

Chemical NameN-Methylpiperidine
Synonym 1-METHYLPIPERIDINE 98+% 1-METHYLPIPERIDINE SOLUTION, FOR PROT.SE Q. ANAL., 40 ML 1-Methylpiperidine 1-Methylpiperidine,97% 1-Pipecoline 1-methylpiperidine N-Methylpiperidine N-methylpiperidine N-methylpiperidine hydrochloride NMPPR {} {} {} {} {} {} {uni_hamburg}
MDL NumberMFCD00006491
CAS Number626-67-5
EC Number210-959-9
Beilstein Registry Number20,16
PubChem Substance ID12291
Chemical Name TranslationN-甲基哌啶
Reaxys-RN1073
Wiswesser Line NotationT6NTJ A1
InChIKeyPAMIQIKDUOTOBW-UHFFFAOYSA-N
LabNetwork Molecule IDLN00010857
InChIInChI=1S/C6H13N/c1-7-5-3-2-4-6-7/h2-6H2,1H3
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Piperidines
  • {SNA} A-D, Alphabetical Listings, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products, M-N
  • {Chemicalbook} 农药中间体: 植物生长调节剂中间体
  • {SNA} Molecular Biology, Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; 1fragment
  • {SNA} Protein Sequencing, Protein Structural Analysis, Proteomics, Reagents for Protein Sequencing
  • {SNA} Protein Sequencing, Protein Structural Analysis, Reagents for Protein Sequencing, 分子生物学, 蛋白质组学

产品应用

  • Reactant for:
  • ·sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
  • ·One-pot synthesis of Z-cinnamic acids
  • Reactant for synthesis of:
  • ·Unsymmetrical ureas
  • ·Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
  • ·C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
  • ·Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases

相关文献及参考

  • Short: III/20a
  • Beilstein:20,16
  • Short: III/35D3
  • Short: III/20c

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S7 Keep container tightly closed 保存在严格密闭容器中;
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTN1225000
Packing GroupII
UN Number 2399 UN2399
Hazard Codes 3 C F,T
Hazard Class3/8
Storage condition -20°C
Warnings 危化品目录(2015)
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BDCGAS Berichte der Deutschen Chemischen Gesellschaft.  (Leipzig, Ger. Dem.
   Rep.)  V.1-61, 1868-1928. For publisher information, see CHBEAM.
   Volume(issue)/page/year: 34,2408,1901

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BEXBAN Bulletin of Experimental Biology and Medicine (English Translation).
   Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY
   10013)  V.41-    1956-  Volume(issue)/page/year: 86,1325,1978

Restrict 危险品

其他信息

  • N-甲基哌啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0403 1-甲基哌啶 1-Methylpiperidine 500ML 993元 2014/06/02 M0403 1-甲基哌啶 1-Methylpiperidine 25ML 137元 2010/06/21 127482500 N-甲基哌啶 N-Methylpiperidine 99% 250 ML 756元
  • MSDS 信息:N-甲基哌啶(626-67-5).msds
  • 和水混溶。溶于甲醇、乙醇、丙酮和甲苯。
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 用途三:药物和有机合成中间体。
  • MOL 文件:626-67-5.mol
  • 类别:易燃液体
  • 方法一:其制备方法是在反应釜中加入哌啶、甲醛,最后加甲酸,加热,保持温度90℃,反应6h,冷却,向混合物加入盐酸,升温加热蒸出过量甲醛和甲酸,残留物冷却,加入氢氧化钠,升温蒸出1-甲基哌啶和水混合物,此混合物经固体氢氧化钠干燥,放到蒸馏釜中蒸馏得产品。
  • 急性毒性:腹腔-小鼠 LD50: 400 毫克/ 公斤; 皮下- 兔子 LDL0: 300 毫克/ 公斤
  • Acros Organics:N-甲基哌啶 N-Methylpiperidine, 99%(626-67-5)
  • 用途一:用作药物和有机合成中间体
  • F:3-10
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氮氧化物烟雾
  • Alfa Aesar:1-甲基哌啶,97% 1-Methylpiperidine, 99%(626-67-5)
  • 上游原料:固体氢氧化钠
  • Sigma Aldrich:626-67-5(sigmaaldrich)
  • 毒性分级:高毒
  • 用途二:1-甲基哌啶是植物生长调节剂甲哌鎓的中间体。
  • 图谱信息:N-甲基哌啶(626-67-5)核磁图( 1 HNMR) N-甲基哌啶(626-67-5)核磁图( 13 CNMR) N-甲基哌啶(626-67-5)质谱(MS) N-甲基哌啶(626-67-5)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 外观性质:无色液体。
  • 海关编码:29333999
  • TCI Shanghai:1-甲基哌啶 1-Methylpiperidine,>;99.0%(GC)(626-67-5)
  • 下游产品:缩节胺

系列性分类


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