Ethyl 2-ethoxyquinoline-1(2H)-carboxylate 2-乙氧基-1(2H)-喹啉羧酸乙酯(EEDQ)
CAS 16357-59-8 MFCD00006703
化学结构图
SMILES: CCOC(=O)N1c2ccccc2C=CC1OCC
化学属性
| Mol. Formula | C14H17NO3 |
|---|---|
| Mol. Weight | 247.29 |
| Melting Point | 63-66°C |
| TSCA | Yes |
| Boiling Point | 355.9°C at 760 mmHg |
| Density | 1.16 |
| Solubility | Soluble in 95% Ethanol (50 mg/ml). Insoluble in water. |
| Stability | 对湿度敏感 |
| Flash Point | 169°C |
别名和识别编码
| Chemical Name | Ethyl 2-ethoxyquinoline-1(2H)-carboxylate |
|---|---|
| CAS Number | 16357-59-8 |
| Alfabeta Name | ETHOXYCARBONYLETHOXYDIHYDROQUINOLINE N212-----, |
| MDL Number | MFCD00006703 |
| Synonym | 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquinoline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Ethoxy-N-(ethoxycarbonyl)-1,2-dihydroquino |
| PubChem Substance ID | 87569624 |
| Beilstein Registry Number | 533048 |
| EC Number | 240-418-2 |
| Reaxys-RN | 533048 |
| Merck Number | 3518 |
| Chemical Name Translation | 2-乙氧基-1(2H)-喹啉羧酸乙酯(EEDQ) |
| Wiswesser Line Notation | T66 BN CHJ BVO2 CO2 |
| Canonical SMILES | O=C(N1C(OCC)C=CC2=C1C=CC=C2)OCC |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Chemical Biology, Chemical Synthesis, Coupling, Other Peptide Coupling, Other Synthetic Reagents for Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents
- {SA} Chemical Biology, Chemical Synthesis, Coupling, Others, Peptide Chemistry, Peptide Coupling, Synthetic Reagents
- {SNA} Chemical Biology, Chemical Synthesis, Coupling, Others, Peptide Chemistry, Peptide Coupling, Synthetic Reagents
产品应用
- 多肽合成中的偶联剂,经典的混合酸酐法多肽缩合剂，作用温和而有效。
- 不可逆膜结合受体拮抗剂.
相关文献及参考
- Merck 14 ,3518
- Reagent for peptide coupling. Reaction proceeds via the anhydride of the acid component: J. Am. Chem. Soc., 90, 823, 1651 (1968); Int. J. Pept. Prot. Res., 26, 493 (1985). See Appendix 6.
- For activation of ɑ -hydroxy acids, see: Tetrahedron Lett, 40, 3435 (1999) . Also used for the mild esterification of alcohols, e.g. for introduction of the levulinate protecting group (see Levulinic acid, A10813): Tetrahedron Lett., 23, 2615 (1982). For a useful esterification technique applicable to primary, secondary and tertiary alcohols, see: J. Org. Chem., 60, 7072 (1995).
- Merck:14,3518 Beilstein: 21,V,3,28
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H302 Harmful if swallowed 吞食有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S37 Wear suitable gloves 戴适当手套；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R38 Irritating to skin 刺激皮肤
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,49,1971
其他信息
- 不溶于水，溶于乙醇。
