7-Chloroquinolin-4-ol 7-氯-4-羟基喹啉

CAS 86-99-7 MFCD00006778

化学结构图

86-99-7
SMILES: Oc1ccnc2cc(Cl)ccc12

化学属性

Mol. FormulaC9H6ClNO
Mol. Weight179.60
Melting Point276-279°C
TSCANo
Appearance 无色针状结晶。熔点276-280℃,微溶于冷水,溶于热水。
Boiling Point302.8°C at 760 mmHg
Flash Point136.9°C

别名和识别编码

Chemical Name7-Chloroquinolin-4-ol
Synonym 7-Chloroquinolin-4-ol {LY} 7-Chloroquinolin-4-ol {} {LY} 7-Chloroquinolin-4-ol {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 7-Chloroquinolin-4-ol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006778
PubChem Substance ID66593
CAS Number86-99-7
EC Number201-715-2
Reaxys-RN125356
Beilstein Registry Number125356
Chemical Name Translation7-氯-4-羟基喹啉
InChIKeyXMFXTXKSWIDMER-UHFFFAOYSA-N
LabNetwork Molecule IDLN00224839
InChIInChI=1S/C9H6ClNO/c10-6-1-2-7-8(5-6)11-4-3-9(7)12/h1-5H,(H,11,12)
Canonical SMILESOC1=CC=NC2=CC(Cl)=CC=C12
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分类

  • Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines

相关文献及参考

  • Aldrich MSDS 1 , 408:C / Corp MSDS 1 (1), 791:A / FT-NMR 1 (3), 431:A / IR-Spectra (3), 1387:H / IR-Spectra (2), 1209:G / RegBook 1 (2), 2615:O / Structure Index 1 , 412:B:8

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • 图谱信息:7-氯-4-羟基喹啉(86-99-7)红外图谱(IR2) 7-氯-4-羟基喹啉(86-99-7)红外图谱(IR1) 7-氯-4-羟基喹啉(86-99-7)质谱(MS)
  • 用途一:医药和染料中间体。可用来合成抗癌症药磷酸氯喹。
  • Sigma Aldrich:86-99-7(sigmaaldrich)
  • MOL 文件:86-99-7.mol
  • Alfa Aesar:7-氯-4-羟基喹啉,98+% 7-Chloro-4-hydroxyquinoline, 98+%(86-99-7)
  • 方法一:在实验室,可加热7-氯-4-羟基喹啉-3-甲酸而得。加热至250-270℃时有大量气泡产生。当气泡停止逸出时,冷却,将反应液倒出,冷后得到固态粗品,再用水重结晶。粗品产率为98%。工业生产可从间氯苯胺出发,经缩合、环合、水解而得7-氯-4-羟基喹啉-3-甲酸,将其与石蜡油一起加热消除,将生成物中上层石蜡油吸去而得7-氯-4-羟基喹啉。
  • 7-氯-4-羟基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1092 7-氯-4-羟基喹啉 7-Chloro-4-hydroxyquinoline 10G 318元 2010/05/25 L07119 7-氯-4-羟基喹啉, 98+% 7-Chloro-4-hydroxyquinoline, 98+% 25g 301元 2010/05/25 L07119 7-氯-4-羟基喹啉, 98+% 7-Chloro-4-hydroxyquinoline, 98+% 100g 839元
  • TCI Shanghai:7-氯-4-羟基喹啉 7-Chloro-4-hydroxyquinoline,>;97.0%(T)(86-99-7)
  • 下游产品:4,7-二氯喹啉
  • 上游原料:矿物油 --> 3-氯苯胺 --> 7-氯-4-羟基喹啉-3-羧酸

系列性分类