2,4-Difluoronitrobenzene 2,4-二氟硝基苯
CAS 446-35-5 MFCD00007050
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks, Nitro Compounds, Nitrogen Compounds, Organic Building Blocks, Organic Fluorinated Building Blocks, Other Fluorinated Organic Building Blocks
- {SA} Aryl Fluorinated Building Blocks, Building Blocks, C6,
产品应用
- 2,4-Difluoronitrobenzene has been used in the synthesis of:
- 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction;
- (±)-horsfiline;
- resin-bound 2-arylaminobenzimidazoles.
相关文献及参考
- Short: EINECS
- Nucleophilic displacement of the activated fluorines with 2-ethyl-4-methylimidazole occurs predominantly at the 2-position, or, under more forcing conditions, at both 2- and 4-positions: J. Med. Chem., 34, 2671 (1991).
- Short: III/38B
安全信息
GHS Symbol
- H227 Combustible liquid 可燃液体
- H301 Toxic if swallowed 吞食有毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H330 Fatal if inhaled 吸入致命
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P302+P350
- P302+P352
- P302+P352+P332+P313+P362+P364
- P304+P340
- P305+P351+P338
- P309+P311
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
- P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P332+P313
- P337+P313
- P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P370+P378
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P403+P235
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- R25 Toxic if swallowed 吞咽有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,185,1992
TYPE OF TEST : LC - Lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1290 mg/m3/1H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,185,1992
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 80 nL/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,217,1983
其他信息
- 方法一:由间二氟苯硝化得到。
- Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.
- 用途一:是药物氟苯布洛芬中间体,也用作农药、液晶材料中间体
- 上游原料:1,3-二氟苯
- Alfa Aesar:2,4-二氟-1-硝基苯,98% 2,4-Difluoro-1-nitrobenzene, 98%(446-35-5)
- 蒸气密度:>;1 (vs air)
- 2,4-二氟硝基苯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1636 2,4-二氟硝基苯 2,4-Difluoronitrobenzene 25G 180元 2014/06/02 D1636 2,4-二氟硝基苯 2,4-Difluoronitrobenzene 500G 1380元 2010/06/21 214480050 2,4-二氟硝基苯 2,4-Difluoronitrobenzene 99% 5 ML 153元
- MOL 文件:446-35-5.mol
- Hazard Note:Irritant
- Sigma Aldrich:446-35-5(sigmaaldrich)
- MSDS 信息:2,4-Difluoronitrobenzene(446-35-5).msds
- Acros Organics:2,4-二氟硝基苯 2,4-Difluoronitrobenzene, 99%(446-35-5)
- 下游产品:2,4-二氟苯胺 --> 5-氟吲哚-2-酮
- 用途二:医药中间体。
- TCI Shanghai:2,4-二氟硝基苯 2,4-Difluoronitrobenzene,>;98.0%(GC)(446-35-5)
- TSCA:T
- 图谱信息:2,4-二氟硝基苯(446-35-5)质谱(MS) 2,4-二氟硝基苯(446-35-5)红外图谱(IR1) 2,4-二氟硝基苯(446-35-5)核磁图( 1 HNMR) 2,4-二氟硝基苯(446-35-5)核磁图( 13 CNMR)