CAS 99-59-2 MFCD00007261-2-Methoxy-5-nitroaniline 2-甲氧基-5-硝基苯胺 TAO{mole}

2-Methoxy-5-nitroaniline 2-甲氧基-5-硝基苯胺

CAS 99-59-2 MFCD00007261

化学结构图

SMILES: COc1ccc([N+](=O)[O-])cc1N

化学属性

Mol. Formula	C7H8N2O3
Mol. Weight	168.15
Melting Point	117-119°C
TSCA	Yes
Appearance	橙红色针状晶体。易溶于丙酮、甲醇、乙醇、苯、乙酸乙酯等。不溶于石油醚。
Solubility	Slightly soluble. <0.01 g/100 mL at 19.5 °C
Density	1.2068
Boiling Point	337.07 °C at 760 mmHg

别名和识别编码

Chemical Name	2-Methoxy-5-nitroaniline
Synonym	2-Methoxy-5-nitroaniline {LY} 2-Methoxy-5-nitroaniline {} {LY} 2-Methoxy-5-nitroaniline {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Methoxy-5-nitroaniline {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00007261
PubChem Substance ID	7447
CAS Number	99-59-2
EC Number	202-770-5
Beilstein Registry Number	13,389
Chemical Name Translation	2-甲氧基-5-硝基苯胺
Reaxys-RN	879620
Wiswesser Line Notation	WNR CZ DO1
LabNetwork Molecule ID	LN00238075
InChI	InChI=1S/C7H8N2O3/c1-12-7-3-2-5(9(10)11)4-6(7)8/h2-4H,8H2,1H3
Canonical SMILES	NC1=CC([N+]([O-])=O)=CC=C1OC

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品牌质保精细包装现货库存一流品牌服务

安全信息

WGK Germany2

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P305+P351+P338+P337+P313
P302+P350
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P337+P313
P302+P352+P332+P313+P362+P364
P301+P312+P330

Hazard statements

H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H303 May be harmfully swallowed 吞食可能有害

Hazard Codes Xi,Xn Xi

RTECSBZ7175000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4368 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,133,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4368 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 524 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-127,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 413 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-127,1978

TYPE OF TEST

{haz

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 25(8),50,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(3),48,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 32(3),48,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 58,11,1978

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

Sigma Aldrich:99-59-2(sigmaaldrich)
TCI Shanghai:2-甲氧基-5-硝基苯胺 2-Methoxy-5-nitroaniline,>;98.0%(LC)(T)(99-59-2)
MOL 文件:99-59-2.mol
色指数:37130
上游原料:2,4-二硝基氯苯 --> 碱性橙 2 --> 二硫化钠 --> 2,4-二硝基苯甲醚 --> 酚酞试纸
用途一:用作染料、颜料及有机合成中间体
用途二:用作染料中间体。
图谱信息:2-氨基-4-硝基苯甲醚(99-59-2)核磁图( 13 CNMR) 2-氨基-4-硝基苯甲醚(99-59-2)质谱(MS) 2-氨基-4-硝基苯甲醚(99-59-2)红外图谱(IR2) 2-氨基-4-硝基苯甲醚(99-59-2)核磁图( 1 HNMR) 2-氨基-4-硝基苯甲醚(99-59-2)红外图谱(IR1)
Hazard Note:Irritant
MSDS 信息:Azoamine Scarlet K(99-59-2).msds
下游产品:弱酸性棕 R
Alfa Aesar:2-甲氧基-5-硝基苯胺,98+% 2-Methoxy-5-nitroaniline, 98+%(99-59-2)
方法一:由2,4-二硝基氯苯经甲氧基化、还原而得。1.甲氧基化将熔融的2,4-二硝基氯苯加入反应锅，再加入甲醇。加热至40℃左右，在4h内先快后慢地加入30%氢氧化钠溶液，温度控制在58-60℃。反应至酚酞试纸对料液显橘红色时为终点，得2,4-二硝基苯甲醚，收率为95%。2.还原将上述甲氧基化生成物冷至30℃，在4h内先快后慢地加入18%的二硫化钠溶液，反应温度从30℃逐度上升至50℃。加完后在50-55℃保温半小时。反应完成后冷却至20℃，压滤、洗涤、干燥，得2-甲氧基-5-硝基苯胺。收率为76%。
Acros Organics:2-甲氧基-5-硝基苯胺 2-Methoxy-5-nitroaniline, 99%(99-59-2)
2-氨基-4-硝基苯甲醚价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 M0492 2-甲氧基-5-硝基苯胺 2-Methoxy-5-nitroaniline 25G 143元 2010/06/21 171300050 2-氨基-4-硝基苯甲醚 2-Methoxy-5-nitroaniline 99% 5 GR 209元 2010/06/16 M0492 2-甲氧基-5-硝基苯胺 2-Methoxy-5-nitroaniline 500G 1770元