CAS 311-45-5 MFCD00007316-Paraoxon-ethyl TAO{mole}

Paraoxon-ethyl

CAS 311-45-5 MFCD00007316

化学结构图

SMILES: CCOP(=O)(OCC)Oc1ccc([N+](=O)[O-])cc1

化学属性

Mol. Formula	C₁₀H₁₄NO₆P
Mol. Weight	275.2
Refractive index	n20/D 1.51(lit.)
Density	1.274 g/mL at 25 °C(lit.)
Boiling Point
Melting Point	No Data Available

别名和识别编码

Chemical Name	Paraoxon-ethyl
CAS Number	311-45-5
Synonym	Ch Chinorto Dia Diethyl 4-Nitrophenyl Phosphate Diethyl p-nitrophenyl phosphate Diethyl p-nitrophenyl phosphate Diethylparaoxon Ester 25 Ethyl paraoxon Mintaco Mintacol Miotisal O,O-Diethyl O-(4-nitrophenyl)-phosphate O,O-Diethyl phosphoric acid O-p-nitrophenyl ester O,O-Dietyl-O-p-nitrofenylfosfat O,O-二乙基 Oxyparathion Parao Paraoxan Paraoxon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	9395
EC Number	206-221-0
Beilstein Registry Number	1915526
MDL Number	MFCD00007316
Chemical Name Translation
Wiswesser Line Notation	WNR DOPO&O2&O2
InChI	InChI=1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3

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产品应用

强效不可逆的乙酰胆碱酯酶抑制剂

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H330 Fatal if inhaled 吸入致命
H310 Fatal in contact with skin 皮肤接触致命
H300 Fatal if swallowed 吞食致命
H300+H310+H330

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes T+,N T+

RTECSTC2275000

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P273 Avoid release to the environment. 避免释放到环境中。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P350
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310+P330
P304+P340+P310
P302+P352+P310
P403+P233
P301+P310

Signal word Danger

Safety Statements

S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
R50 Very toxic to aquatic organisms 对水生生物极毒

Storage condition -20 储存温度2-8℃

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 240 ug/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - other esterases
REFERENCE :
   CJBPAZ Canadian Journal of Biochemistry and Physiology.  (Ottawa, Ont.,
   Canada)  V.32-41, 1954-63. For publisher information, see CJBIAE.
   Volume(issue)/page/year: 34,197,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 446 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   22,317,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   25,329,1969

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TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 560 ug/kg
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - true cholinesterase
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York,

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 8,939,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 117,139,1983

其他信息

易溶于醚及其他有机溶剂，在水中的溶解度为1：100。水溶液在中性时稳定